Degranulation and decrease in histamine levels of thalamic mast cells coincides with corticosterone secretion induced by compound 48/80

Bugajski, Andrzej; Chłap, Z; Gàdek-Michalska, A; Borycz, J; Bugajski, J

doi:10.1007/bf01674391

Cited by 28 publications

(13 citation statements)

References 8 publications

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“…We and others reported that stimulation of nasal MCs leads to activation of the HPA [130][131][132] driving the organism into a fight-or-flight mode. Recently, olfactory and taste receptors were identified in subpopulations of human-circulating leukocytes [133].…”

Section: Stress Crh and Immune Cellsmentioning

confidence: 98%

Neuroendocrinology of the skin

Theoharides

Stewart

Taracanova

et al. 2016

Rev Endocr Metab Disord

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The skin is considered the mirror of the soul and is affected by neurohormonal triggers, especially stress. Hair follicles, keratinocytes, mast cells, melanocytes, and sebocytes all express sex and stress hormones implicating them in a local "hypothalamic-pituitary-adrenal axis." In particular, the peptides corticotropin-releasing hormone (CRH) and neurotensin (NT) have synergistic action stimulating mast cells and are uniquely elevated in the serum of patients with skin diseases exacerbated by stress. Addressing the neurohormonal regulation of skin function could lead to new targets for effective treatment of inflammatory skin diseases.

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Section: Stress Crh and Immune Cellsmentioning

confidence: 98%

Neuroendocrinology of the skin

Theoharides

Stewart

Taracanova

et al. 2016

Rev Endocr Metab Disord

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“…Mast cells are localized close to CRH-positive neurons in the median eminence [278] and express functional CRH receptors [44]. Activation of hypothalamic mast cells can stimulate the HPA axis [279-281], through histamine, which regulates the hypothalamus, and can also increase hypothalamic CRH mRNA expression [282]. Moreover, human mast cells can synthesize and secrete large amounts of CRH [283], as well as IL-1 and IL-6 which are independent activators of the HPA axis [284].…”

Section: Multiple Sclerosismentioning

confidence: 99%

Mast cells and inflammation

Theoharides

Alysandratos

Angelidou

et al. 2012

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

652

531

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Mast cells are well known for their role in allergic and anaphylactic reactions, as well as their involvement in acquired and innate immunity. Increasing evidence now implicates mast cells in inflammatory diseases where they are activated by non-allergic triggers, such as neuropeptides and cytokines, often exerting synergistic effects as in the case of IL-33. Mast cells can also release pro-inflammatory mediators selectively without degranulation. In particular, IL-1 induces selective release of IL-6, while corticotropin-releasing hormone secreted under stress induces the release of vascular endothelial growth factor. Many inflammatory diseases involve mast cells in cross-talk with T cells, such as atopic dermatitis, psoriasis and multiple sclerosis, which all worsen by stress. How mast cell differential responses are regulated is still unresolved. Preliminary evidence suggests that mitochondrial function and dynamics control mast cell degranulation, but not selective release. Recent findings also indicate that mast cells have immunomodulatory properties. Understanding selective release of mediators could explain how mast cells participate in numerous diverse biologic processes, and how they exert both immunostimulatory and immunosuppressive actions. Unraveling selective mast cell secretion could also help develop unique mast cell inhibitors with novel therapeutic applications.

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“…It is known that histamine receptors are densely concentrated in the thalamus (Pillot et al, 2002) and can control presynaptic glutamate release (Garduno-Torres et al, 2007). Moreover, thalamic mast cell degranulation and histamine release coincides with corticosterone secretion (Bugajski et al, 1995), which is reduced by pretreatment with histamine receptor antagonists (Gadek-Michalska et al, 1991). Previously, it has been shown that mast cells can express corticotrophin-releasing factor receptors (Cao et al, 2005) and can even release corticotrophin-releasing factor (Theoharides et al, 2004) and corticosterone (Csaba et al, 1967).…”

Section: Discussionmentioning

confidence: 99%

Thalamic mast cell activity is associated with sign-tracking behavior in rats

Fitzpatrick

Morrow

2017

Brain, Behavior, and Immunity

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Mast cells are resident immune cells in the thalamus that can degranulate and release hundreds of signaling molecules (i.e., monoamines, growth factors, and cytokines) both basally and in response to environmental stimuli. Interestingly, mast cell numbers in the brain show immense individual variation in both rodents and humans. We used a Pavlovian conditioned approach (PCA) procedure to examine whether mast cells are associated with individual variation in the attribution of incentive-motivational value to reward-related cues. During the PCA procedure, a lever response-independently predicts the delivery of a food pellet into a magazine, and over training sessions three conditioned responses (CRs) develop: sign-tracking (lever-directed CRs), goal-tracking (magazine-directed CRs), and an intermediate response (both CRs). In Experiment 1, we measured thalamic mast cell number/activation using toluidine blue and demonstrated that sign-trackers have increased degranulated (activated) but not granulated (inactive) mast cells. In Experiment 2, we infused the mast cell inhibitor, cromolyn (200 µg/rat; i.c.v.), immediately before five daily PCA training sessions and demonstrated that mast cell inhibition selectively impairs the acquisition of sign-tracking behavior. Taken together, these results demonstrate that thalamic mast cells contribute to the attribution of incentive-motivational value to reward-related cues and suggest that mast cell inhibition may be a novel target for addiction treatment.

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Degranulation and decrease in histamine levels of thalamic mast cells coincides with corticosterone secretion induced by compound 48/80

Cited by 28 publications

References 8 publications

Neuroendocrinology of the skin

Neuroendocrinology of the skin

Mast cells and inflammation

Thalamic mast cell activity is associated with sign-tracking behavior in rats

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