Degradation versus fibrillogenesis, two alternative pathways modulated by seeds and glycosaminoglycans
Guglielmo Verona,
Sara Raimondi,
Diana Canetti
et al.
Abstract:The mechanism that converts native human transthyretin into amyloid fibrils in vivo is still a debated and controversial issue. Commonly, non‐physiological conditions of pH, temperature, or organic solvents are used in in vitro models of fibrillogenesis of globular proteins. Transthyretin amyloid formation can be achieved under physiological conditions through a mechano‐enzymatic mechanism involving specific serine proteases such as trypsin or plasmin. Here, we investigate S52P and L111M transthyretin variants… Show more
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