Degradation profile and preliminary clinical testing of a resorbable device for ligation of blood vessels

Aminlashgari, Nina; Höglund, Odd Viking; Borg, Niklas; Hakkarainen, Minna

doi:10.1016/j.actbio.2013.02.018

Cited by 18 publications

(34 citation statements)

References 28 publications

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“…Ultrasonographic visualization of the device was no longer possible an average of 3.6 months after ligation of the spermatic cord in dogs, which is consistent with complete resorption during this period . During biomechanical testing, the device could withstand a load of 23 N at a strain of 25% both before and 1 week after degradation; these results provide evidence to suggest that sufficient strength is maintained throughout the healing time of blood vessels . Histopathologic evaluation of compressed ovarian pedicle in dogs was consistent with complete occlusion of vessels .…”

Section: Discussionmentioning

confidence: 53%

“…Histopathologic evaluation of compressed ovarian pedicle in dogs was consistent with complete occlusion of vessels . In all studies, the device maintained effective tissue grip and complete hemostasis …”

Section: Discussionmentioning

confidence: 62%

“…The current version of LigaTie (made of poly[GA‐co‐TMC]) has been efficacious for ligation of ovarian pedicles, spermatic cords, renal arteries, pulmonary hilus, and cystic ducts . Ultrasonographic visualization of the device was no longer possible an average of 3.6 months after ligation of the spermatic cord in dogs, which is consistent with complete resorption during this period .…”

Section: Discussionmentioning

confidence: 65%

“…The device currently available is made of glycolide and trimethylene carbonate, a block copolymer equivalent to the resorbable suture Maxon. The device has been tested on renal arteries, lung lobectomy, and gonadectomy in male and female dogs . The small size and flexibility of this device make it attractive as a tool to obtain peripheral lung biopsy samples, especially in small‐breed dogs and cats, in which maneuvering stapling devices is limited by the lack of working space within the thoracic cavity.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of a resorbable self‐locking ligation device for performing peripheral lung biopsies in a caprine cadaveric model

et al. 2019

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Objective To compare airway leak pressures after sealing peripheral lung biopsy sites with a resorbable ligation device (LigaTie) or thoracoabdominal (TA) staples. Study design Ex vivo study. Animals Four normal caprine cadavers. Methods Twelve lung lobes were harvested from 4 goats immediately after euthanasia. Each lobe was inflated to 20 cm H2O to test for leaks prior to biopsy. Pressure was then maintained at 10 cm H2O. Biopsy samples were obtained 3 cm from the periphery with a resorbable ligation device or a TA stapler (n = 6 per group). After biopsy, inflation pressure was slowly increased to 40 cm H2O while lungs were submerged in water. The pressure at which bubbles were first seen was recorded as the airway leak pressure. The length, width, volume, and weight were recorded for each biopsy sample. Results Five of 6 LigaTie biopsy sites sustained the maximum pressure of 40 cm H2O without leaking. One site leaked at 24 cm H2O. The TA‐stapled sites sustained airway pressure to median 25.5 cm H2O (interquartile range, 23.5–26 cm H2O), and none of them reached the maximum pressure (P = .015). There were no differences in biopsy length, volume, or weight between groups. Conclusion Biopsy sites sealed with LigaTie withstood higher airway pressure without leaking compared with TA‐stapled biopsy sites in normal cadaveric specimens. Clinical significance The LigaTie may be an alternative technique for sealing peripheral lung biopsy sites.

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 99%

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Evaluation of a resorbable self‐locking ligation device for performing peripheral lung biopsies in a caprine cadaveric model

et al. 2019

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“…Less surgical stress at ovary removal has been reported in healthy dogs with a laparoscopic technique compared to the traditional open abdomen technique [11] and a laparoscopic-assisted technique for pyometra is described [40–42]. Furthermore, development of a new method for ligation of the mesovarium may enable a more standardized technique with potentially less noxious stimuli [43–45]. …”

Section: Discussionmentioning

confidence: 99%

Blood pressure and heart rate during ovariohysterectomy in pyometra and control dogs: a preliminary investigation

Höglund

Lövebrant²,

Olsson

et al. 2016

Acta Vet Scand

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BackgroundSurgery causes a stress response, a physiologic response to trauma. The intraoperative surgical stress response in dogs diagnosed with pyometra has not previously been described. The aim of this study was to investigate the intraoperative surgical stress response, assessed by blood pressure and heart rate measurements, in dogs diagnosed with pyometra and healthy controls. All dogs were premedicated with acepromazine and methadone, anaesthesia was induced with propofol and maintained with isoflurane, where after the dogs were subjected to ovariohysterectomy.ResultsEight dogs diagnosed with pyometra and eight healthy controls were used. Systolic blood pressure and heart rate were measured to assess the surgical stress response. Additionally propofol dosage at induction of anaesthesia and the end-tidal isoflurane concentration were investigated. The surgery was split into four phases. Phase 0 was the period 10 min before the skin incision, phase 1 was skin incision and opening of abdomen, phase 2 was manipulation of uterine horns, lifting of the ovary with stretching of the mesovarium, ligation and transection of mesovarium and phase 3 was ligation and transection of cervix, removal of organs and closing of the abdomen. Dosage of propofol at induction of anaesthesia was 3.6 ± 1 mg/kg in dogs with pyometra and 4.1 ± 1 in healthy controls (P = 0.37). In both groups, systolic blood pressure increased between phase 1 and 2, from 87 ± 15 to 114 ± 19 mmHg in dogs with pyometra, and from 88 ± 18 to 106 ± 20 mmHg in healthy controls, (both P < 0.0001). Systolic blood pressure did not differ significantly between groups in any of the phases. Heart rate and end-tidal concentration of isoflurane did not differ significantly between phases or between groups.ConclusionsThe increased blood pressure at removal of ovaries during ovariohysterectomy suggests a pronounced noxious stimulus at this part of the procedure. In principle, the study parameters and response to surgery did not differ significantly between dogs with pyometra and healthy controls.

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In Vivo Versus In Vitro Degradation of a 3D Printed Resorbable Device for Ligation of Vascular Tissue in Horses

Adolfsson

Sjöberg

Höglund

et al. 2021

Macromolecular Bioscience

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A resorbable 3D printed polydioxanone (PDO) device is manufactured to facilitate ligation of vascular tissue during surgery. The device must provide sufficient mechanical performance throughout the healing period. Therefore, degradation and mechanical performance of the device are investigated as a function of in vivo and in vitro aging. During aging the PDO device released cyclic and linear water‐soluble products. In vivo aging resulted in higher relative number of linear oligomers in comparison to in vitro aging. A major loss of mechanical performance is observed after only 10 days in vivo and the Young’s modulus (E) and tensile strength at break (σb) decreased by 28% and 54%, respectively. This is in contrast to in vitro aging, where no loss of mechanical properties is observed during the same period. The in vivo aged devices exhibit clear holes in the matrices after 28 days, while apparent cracks are observed first after 140 days in vitro. These results highlight the sensitivity of the degradation process of resorbable devices with regards to the interactions of the device with the surrounding environment (tissues) and demonstrate the importance of in vivo testing as compliment to in vitro testing before clinical use of devices.

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Degradation profile and preliminary clinical testing of a resorbable device for ligation of blood vessels

Cited by 18 publications

References 28 publications

Evaluation of a resorbable self‐locking ligation device for performing peripheral lung biopsies in a caprine cadaveric model

Evaluation of a resorbable self‐locking ligation device for performing peripheral lung biopsies in a caprine cadaveric model

Blood pressure and heart rate during ovariohysterectomy in pyometra and control dogs: a preliminary investigation

In Vivo Versus In Vitro Degradation of a 3D Printed Resorbable Device for Ligation of Vascular Tissue in Horses

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