Degradation profile and identification of the major degradation products of dobupride under several conditions by GC/MS and HPLC-particle beam/MS

Segarra, Vı́ctor; Carrera, Francesc; Fabregas, José-Luis; Claramunt, Juan

doi:10.1016/0731-7085(95)01521-l

Cited by 6 publications

(1 citation statement)

References 4 publications

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“…Mass spectrometry (MS) has found widespread use in oxidation studies of pharmaceutical chemicals (12)(13)(14) due to its ability to provide unambiguous determination of analyte structure. The recently developed ionization techniques, electrospray (ESI) and atmospheric pressure chemical ionization (APCI), have been successfully used in analyses of nonvolatile drug-related compounds (15)(16)(17).…”

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confidence: 99%

New oxidation pathway of 3,5‐di‐tert‐butyl‐4‐hydroxytoluene: An ionspray tandem mass spectrometric and gas chromatographic/mass spectrometric study

Zhang¹,

Kawakami²,

Higaki³

et al. 1997

J Americ Oil Chem Soc

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The autoxidation of 3,5-di-tert-butyl-4-hydroxytoluene (BHT, 1) in bar soap was investigated with ionspray tandem mass spectrometric and on-line gas chromatographic/mass spectrometric methods. The oxidation products of BHT were extracted from the bar soap surface, concentrated, and fractionated with open-column chromatography to remove the impurities. New oxidation products of BHT (BHT phenol-type dimer 7 and others) were identified with the two mass spectrometric methods. The results suggested that oxidation of BHT in bar soap occurred in a way different from that in the previous studies. In the new pathway, oxidation of BHT first generates an excited state of phenol-type dimer 4, and then this species decomposes, due to its high energy, to form dimer 7. The mechanism of oxidation is discussed. JAOCS 74, 781-786 (1997).

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confidence: 99%