Degradation of β-blockers in hospital wastewater by means of ozonation and Fe2+/ozonation

Wilde, Marcelo L.; Montipó, Sheila; Martins, Ayrton F.

doi:10.1016/j.watres.2013.09.039

Cited by 83 publications

(32 citation statements)

References 75 publications

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“…1). The CH 3 OCH 2 CH 2 À moiety on R3 of MT is weak electron-withdrawing, in comparison to a higher electron withdrawing moiety NH 2 COCH 2 À of AT [45], which may result in a less polar feature of MT and thus, a reduced electrostatic interaction between MT and kaolinite, in comparison to that between AT and kaolinite. Moreover, the polar surface area (PSA) was 53 and 91 Å 2 for MT and AT, although their total surface areas were similar with MT being 395 Å 2 and AT at 371 Å 2 [33].…”

Section: Discussion On Mt Sorption Mechanismsmentioning

confidence: 99%

Contrasting mechanisms of metoprolol uptake on kaolinite and talc

Fitzgerald

Albert

et al. 2015

Chemical Engineering Journal

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Section: Discussion On Mt Sorption Mechanismsmentioning

confidence: 99%

Contrasting mechanisms of metoprolol uptake on kaolinite and talc

Fitzgerald

Albert

et al. 2015

Chemical Engineering Journal

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“…In addition, it should be pointed out that MET have tartrate as counter ions, the real structure is [C 15 H 25 NO 3 ] 2 C 4 H 6 O 6 with MW = 684.8 which, to some extent, can act as HO • scavengers and decrease the efficiency of degradation of MET [13].…”

Section: Met Removalmentioning

confidence: 99%

“…Among these pharmaceuticals, ␤-blockers are considered emerging contaminants and they are widely used not only in hospitals but also domestically, thus their presence in water bodies is significant. Metoprolol tartrate salt (MET {1- [4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol tartrate (2:1)}) is one of the most commonly used ␤-blockers for the treatment of variety of cardiovascular diseases, such as hypertension, coronary artery disease, and arrhythmias [12][13][14]. Their presence has been measured in effluents of wastewater treatment plants (WWTP) at concentrations around 730 ng L −1 [15], hospital wastewater (HWW, 417-2232 ng L −1 ) [16] and surface water at concentrations of 2200 ng L −1 [17].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of B-doped TiO2 and their performance for the degradation of metoprolol

et al. 2015

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“…Rosal et al reported degradation of 99% of ATE when treating effluents from a sewage treatment plant with ozone and H 2 O 2 . In hospital effluent, Wilde et al reported 90% degradation after 60 min with an ozone flow of 400 mg/L.h and Ling et al degradation of 78% by applying 50 mg/h of ozone in water. Other studies have also shown that photocatalysis coupled with ozonation can improve the efficiency of ATE degradation in shorter experiment times .…”

Section: Resultsmentioning

confidence: 99%

Oxidative treatments for atenolol removal in water: Elucidation by mass spectrometry and toxicity evaluation of degradation products

Quaresma

Sousa

Silva

et al. 2019

Rapid Comm Mass Spectrometry

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Rationale The presence of pharmaceuticals in water is a worldwide concern due to potential damage to human and environmental health. For example, compounds such as the β‐blocker atenolol (ATE), widely used for the treatment of cardiac disease, are detected in drinking water since conventional water treatment plants are not designed to remove them. Thus, the evaluation of ATE removal at different water oxidative treatment processes, identification of its degradation products and evaluation of their toxicity is necessary. Methods Aqueous solutions of ATE (10 mg/L) were submitted to oxidative treatments of chlorination ([NaClO] = 10 mg/L), ozonation ([O3] = 8 mg/L), photocatalysis ([TiO2] = 120 mg/L and UV‐C light) and photolysis (UV‐C light). The removal of ATE and formation of degradation products (DPs) were monitored by mass spectrometry. To assess acute cytotoxicity, DPs were submitted to colorimetric MTT assay using HepG2 cells. The Ecological Structure Activity Relationships (ECOSAR) software was applied to estimate the acute and chronic toxicity of identified DPs at different trophic levels. Results Photocatalysis was the treatment that demonstrated greater efficiency, removing 94% of the initial ATE. For the four tested treatments, 12 DPs were confirmed after 30 min. Moreover, some of the identified DPs were unpublished in the literature. Through high‐resolution mass spectrometry (HRMS), it was possible to elucidate the structure of the DPs. Solutions of DPs were not considered to be toxic to HepG2 cells. Only the DP with a molecular formula of C13H19NO3 (m/z 238.1438) could be considered detrimental to daphnid and green algae. Conclusions Low rates of organic matter removal and high rates of ATE degradation were obtained in the applied treatments after 30 min. Although the treated solutions were not toxic to HepG2 cells, one of the degradation products can be considered an environmental concern since it presents chronic toxicity to daphnid and green algae.

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Degradation of β-blockers in hospital wastewater by means of ozonation and Fe2+/ozonation

Cited by 83 publications

References 75 publications

Contrasting mechanisms of metoprolol uptake on kaolinite and talc

Contrasting mechanisms of metoprolol uptake on kaolinite and talc

Synthesis and characterization of B-doped TiO2 and their performance for the degradation of metoprolol

Oxidative treatments for atenolol removal in water: Elucidation by mass spectrometry and toxicity evaluation of degradation products

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