Degradation of α-Subunits, Doa1 and Doa4, are Critical for Growth, Development, Programmed Cell Death Events, Stress Responses, and Pathogenicity in the Watermelon Fusarium Wilt Fungus Fusarium oxysporum f. sp. niveum
Abstract:The ubiquitin−proteasome system (UPS) regulates protein quality or control and plays essential roles in several biological and biochemical processes in fungi. Here, we present the characterization of two UPS components, FonDoa1 and FonDoa4, in watermelon Fusarium wilt fungus, Fusarium oxysporum f. sp. niveum (Fon), and their biological functions. FonDoa1 localizes in both the nucleus and cytoplasm, while FonDoa4 is predominantly present in the cytoplasm. Both genes show higher expression in germinating macroco… Show more
“…In this context, remarkable progress is being made in the development of new bioactive compounds against phytopathogens such as FOX on a weekly basis. 10–18 However, many of these advancements come with a significant drawback. Most active compounds are derived from natural sources, resulting in limited quantities that make it challenging to conduct thorough testing and field evaluations.…”
The gram-scale synthesis of benzofuranyl acetic acid via a Willgerodt–Kindler rearrangement is presented. Additionally, the antifungal activity against Fusarium oxysporum was tested for ten different benzofuranyl acetic acid amides.
“…In this context, remarkable progress is being made in the development of new bioactive compounds against phytopathogens such as FOX on a weekly basis. 10–18 However, many of these advancements come with a significant drawback. Most active compounds are derived from natural sources, resulting in limited quantities that make it challenging to conduct thorough testing and field evaluations.…”
The gram-scale synthesis of benzofuranyl acetic acid via a Willgerodt–Kindler rearrangement is presented. Additionally, the antifungal activity against Fusarium oxysporum was tested for ten different benzofuranyl acetic acid amides.
Fusarium wilt, caused by the soil-borne fungal pathogen Fusarium oxysporum f. sp. niveum (Fon), threatens global watermelon production. Conventional fungicides have limitations in efficacy and environmental impact, prompting the search...
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