Degradation of ZIF-8 in phosphate buffered saline media

Velasquez, Miriam; Riccò, Raffaele; Carraro, Francesco; Limpoco, F. T.; Linares‐Moreau, Mercedes; Leitner, Erich; Wiltsche, Helmar; Rattenberger, Johannes; Schröttner, Hartmuth; Frühwirt, Philipp; Stadler, Eduard; Gescheidt, Georg; Amenitsch, Heinz; Doonan, Christian J.; Falcaro, Paolo

doi:10.1039/c9ce00757a

Cited by 220 publications

(209 citation statements)

References 55 publications

(78 reference statements)

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“…41,42 However, this assay is generally performed in phosphate buffer, a condition recently proven detrimental to ZIF-8 stability. 43 After confirming that the results are fully comparable with the assay performed in phosphate buffer ( Figure S7 and S8, ESI), we used pure water to run the assay. The role of pure MNPs in the enzymatic response was also studied, finding that they do not interfere with the assay, i.e.…”

Section: Recirculator Setupsupporting

confidence: 60%

Magnetically Responsive Horseradish peroxidase@ZIF-8 for Biocatalysts

Riccò¹,

Amenitsch²,

Falcaro³

2019

Preprint

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<div>Here, we studied a catalytically active and magnetically responsive porous bio-composite obtained from the synthesis of ZIF-8 in presence of iron oxide magnetic nanoparticles and horseradish peroxidase (HRP) enzyme as guest species. Using a one-pot approach in water the precursors of ZIF-8 (zinc acetate and 2-methylimidazole) spontaneously self-assembles around the guest species. We characterized the composite by means of XRD, SEM, FTIR, AFM, and CLSM. SAXS investigation of the kinetics of crystallization showed how the presence of the guest species can act as nucleation seeds. Moreover, we found that the bio-catalytic activity of the HRP/MNP@ZIF-8 biocomposite is 5 times higher than the analoguous composite without MNPs.</div>

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Section: Recirculator Setupsupporting

confidence: 60%

Magnetically Responsive Horseradish peroxidase@ZIF-8 for Biocatalysts

Riccò¹,

Amenitsch²,

Falcaro³

2019

Preprint

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“…Therefore, the particle size must be considered when synthesizing drug sustained-release ZIF-8-based composite materials. 59 Duan et al used non-toxic polyallylamine hydrochloride (PAH) to synthesize DOXencapsulated ZIF-8 (DOX@Azif-8) with a one-pot method at room temperature. The reaction was fast, the yield was high, and the prepared DOX@Azif-8 size could be precisely controlled (30-150 nm).…”

Section: Zif-8@mesoporous Nanoparticle Compositesmentioning

confidence: 99%

Synthesis and modification of ZIF-8 and its application in drug delivery and tumor therapy

et al. 2020

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“…The most extensively investigated topology is sodalite ( sod ) as it has been shown to afford crystalline microporous materials that can protect encapsulated proteins from inhospitable environments . Furthermore, the sod ZIF‐8 coating can be degraded under mild conditions (mild acidic conditions, phosphate ions or chelating agents) allowing for triggered release of the encapsulated biomolecule with retention of its native activity …”

Section: Figurementioning

confidence: 99%

Continuous‐Flow Synthesis of ZIF‐8 Biocomposites with Tunable Particle Size

et al. 2020

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Zeolitic imidazolate framework (ZIF) biocomposites show the capacity to protect and deliver biotherapeutics. To date, the progress in this research area is based on laboratory batch methods. Now, the first continuous flow synthetic method is presented for the encapsulation of a model protein (bovine serum albumin, BSA) and a clinical therapeutic (α1‐antitrypsin, AAT) in ZIF‐8. The in situ kinetics of nucleation, growth, and crystallization of BSA@ZIF‐8 were studied by small‐angle X‐ray scattering. By controlling the injection time of ethanol, the particle growth could be quenched by ethanol‐induced crystallization from amorphous particles to ZIF‐8 crystals. The particle size of the biocomposite was tuned in the 40–100 nm range by varying residence time prior to introduction of ethanol. As a proof‐of‐concept, this procedure was used for the encapsulation of AAT in ZIF‐8. Upon release of the biotherapeutic from the composite, the trypsin inhibitor function of AAT was preserved.

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Degradation of ZIF-8 in phosphate buffered saline media

Abstract: Understanding the stability of zeolitic imidazolate framework-8 (ZIF-8) under physiological conditions is critical in biotechnology and biomedicine for biosensing, biocatalysis, and drug delivery.

Cited by 220 publications

References 55 publications

Magnetically Responsive Horseradish peroxidase@ZIF-8 for Biocatalysts

Magnetically Responsive Horseradish peroxidase@ZIF-8 for Biocatalysts

Synthesis and modification of ZIF-8 and its application in drug delivery and tumor therapy

Continuous‐Flow Synthesis of ZIF‐8 Biocomposites with Tunable Particle Size

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