Degradation of the anticancer drug flutamide by solar photo-Fenton treatment at near-neutral pH: Identification of transformation products and in silico (Q)SAR risk assessment

Removal of captopril pharmaceutical from synthetic pharmaceutical-industry wastewaters: Use of activated carbon derived from Butia catarinensis

“…The treatment of waters and wastewaters containing pharmaceuticals is usually carried out using solar photo-Fenton [8,9], photolysis and photocatalysis [10][11][12], photo-Fenton electrochemical degradation [13], electrochemical oxidation [14], activated sludges [15,16], filtration [17,18], and adsorption [19][20][21][22][23][24]. However, these methodologies have shortcomings, such as high costs and high generation of sludges [25] and the formation of by-products [8,9].…”

“…The treatment of waters and wastewaters containing pharmaceuticals is usually carried out using solar photo-Fenton [8,9], photolysis and photocatalysis [10][11][12], photo-Fenton electrochemical degradation [13], electrochemical oxidation [14], activated sludges [15,16], filtration [17,18], and adsorption [19][20][21][22][23][24]. However, these methodologies have shortcomings, such as high costs and high generation of sludges [25] and the formation of by-products [8,9]. This situation calls for further development of wastewater treatment methods and, in particular, adsorption presents some advantages for the treatment of effluents contaminated with pharmaceuticals, such as initial low cost for its implementation and easy operation.…”

Exploring the potential biomarkers for prognosis of glioblastoma via weighted gene co-expression network analysis

“…Hydroxylation is a post-translational modification affecting protein stability, activity or interactome ( Zurlo & Zhang, 2020 ). Many cancers are related to protein hydroxylation, such as breast cancer ( Zurlo & Zhang, 2020 ), gastric cancer ( Li et al, 2020 ), and prostate cancer ( Della-Flora et al, 2020 ). For example, a study found that a set of enzymes PLOD1, PLOD2 and PLOD3 involved in the hydroxylation of lysine and stabilization of collagen by crosslinks, which up-regulated expression in gastric cancer patients ( Li et al, 2020 ).…”

Challenges on solar oxidation as post-treatment of municipal wastewater from UASB systems: Treatment efficiency, disinfection and toxicity

“…Quantitative Structure-Activity Relationship (QSARs) consist of computational models that predict the toxicological behavior of detected compounds based on their physicochemical properties ( Pizzo et al, 2013 ). Della-Flora et al (2020) assessed the environmental fate and ecotoxicity of anticancer drug flutamide and TPs generated during the degradation of this compound via solar photo-Fenton (pH 5.0; Fe 2+ 5 mg L −1 ; H 2 O 2 50 mg L −1 ) using in silico QSARs predictions. QSAR predictions linked detected TPs to mutagenicity and carcinogenicity effects which were confirmed by software analysis based on structural signs.…”