Degradation of phospholipid polymer hydrogel by hydrogen peroxide aiming at insulin release device

Uchiyama, Tetsuya; Kiritoshi, Yoshihiro; Watanabe, Junji; Ishihara, Kazuhíko

doi:10.1016/s0142-9612(03)00441-1

Cited by 43 publications

(31 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In recent years, several stimuli-responsive nano-devices have been described to be capable of responding to changes in pH 117 , shear pressure 118 and external stimuli (that is, light 119 , magnetic forces 120 or ultrasonic waves 121 ) to release drugs. For example, a nanonetwork of insulin with PLGA (poly(lactic-co-glycolic acid)) nanoparticles releases insulin at basal levels and releases a burst of insulin upon exposure to ultrasound 121 .…”

Section: Insulin Deliverymentioning

confidence: 99%

Managing diabetes with nanomedicine: challenges and opportunities

Veiseh

Tang

Whitehead

et al. 2014

Nat Rev Drug Discov

500

407

View full text Add to dashboard Cite

Nanotechnology-based approaches hold substantial potential for improving the care of patients with diabetes. Nanoparticles are being developed as imaging contrast agents to assist in the early diagnosis of type 1 diabetes. Glucose nanosensors are being incorporated in implantable devices that enable more accurate and patient-friendly real-time tracking of blood glucose levels, and are also providing the basis for glucose-responsive nanoparticles that better mimic the body’s physiological needs for insulin. Finally, nanotechnology is being used in non-invasive approaches to insulin delivery and to engineer more effective vaccine, cell and gene therapies for type 1 diabetes. Here, we analyse the current state of these approaches and discuss key issues for their translation to clinical practice.

show abstract

Section: Insulin Deliverymentioning

confidence: 99%

Managing diabetes with nanomedicine: challenges and opportunities

Veiseh

Tang

Whitehead

et al. 2014

Nat Rev Drug Discov

500

407

View full text Add to dashboard Cite

show abstract

“…While superoxide is too short‐lived to diffuse into the PEGDA hydrogel, the molecule rapidly reacts with NO • to form OONO − and decomposes to H 2 O 2 20–22. Both molecules have significantly longer half‐lives and are predicted to diffuse deeply into the hydrogel capsule 55, 56. It is oxidative damage from these ROS that likely mediates the reduced metabolic activity observed when cells in blank hydrogels are treated with superoxide.…”

Section: Discussionmentioning

confidence: 99%

Polymerizable superoxide dismutase mimetic protects cells encapsulated in poly(ethylene glycol) hydrogels from reactive oxygen species‐mediated damage

Hume¹,

Anseth²

2011

J Biomedical Materials Res

View full text Add to dashboard Cite

A polymerizable superoxide dismutase mimetic (SODm) was incorporated into poly(ethylene glycol) (PEG) hydrogels to protect encapsulated cells from superoxide-mediated damage. Superoxide and other small reactive oxygen species (ROS) can cause oxidative damage to donor tissue encapsulated within size exclusion barrier materials. To enzymatically breakdown ROS within biomaterial cell encapsulation systems, Mn(III) Tetrakis[1-(3-acryloxy-propyl)-4-pyridyl] porphyrin (MnTTPyP-acryl), a polymerizable manganese metalloporphyrin SOD mimetic, was photopolymerized with PEG diacrylate (PEGDA) to create functional gels. In unmodified PEG hydrogels, a significant reduction in metabolic activity was observed when encapsulated Min6 β-cells were challenged with chemically generated superoxide. Cells encapsulated within MnTPPyP-co-PEG hydrogels, however, demonstrated greatly improved metabolic activity following various superoxide challenges. Further, cells were encapsulated and cultured for 10 days within MnTPPyP-co-PEG hydrogels and challenged with superoxide on days 4, 6, and 8. At the conclusion of this study, cells in blank PEG hydrogels had no observable metabolic activity but when encapsulated in MnTPPyP-functionalized hydrogels, cells retained 60 ± 5% of the metabolic activity compared to untreated controls.

show abstract

“…In addition to scavenging the H 2 O 2 generated from the GOx catalytic reaction, H 2 O 2 itself can also be used as a trigger for insulin release. [55,56] For example, Hu et al utilized a transcutaneous microneedle array patch strategy to directly exploit the generated H 2 O 2 to oxidize and hydrolyze the grafted phenylboronic esters of an amphiphilic copolymer. Upon exposure to generated H 2 O 2 , the scaffold became water-soluble, leading to the disassembly of polymeric vesicles and insulin release.…”

Section: H 2 O 2 -Responsive Systemsmentioning

confidence: 99%

Glucose‐Responsive Insulin and Delivery Systems: Innovation and Translation

et al. 2019

View full text Add to dashboard Cite

Glucose‐responsive insulin and insulin‐delivery systems that mimic the function of beta cells can enhance health and quality of life of people with diabetes. In article number 1902004, Zhen Gu and co‐workers provide an overview and recent progress in the development of synthetic approaches for glucose‐responsive insulin delivery systems. Rational design of glucose‐responsive strategies, materials, formulations, and related devices are highlighted.

show abstract

Degradation of phospholipid polymer hydrogel by hydrogen peroxide aiming at insulin release device

Cited by 43 publications

References 30 publications

Managing diabetes with nanomedicine: challenges and opportunities

Managing diabetes with nanomedicine: challenges and opportunities

Polymerizable superoxide dismutase mimetic protects cells encapsulated in poly(ethylene glycol) hydrogels from reactive oxygen species‐mediated damage

Glucose‐Responsive Insulin and Delivery Systems: Innovation and Translation

Contact Info

Product

Resources

About