Degradation of <i>Alternaria</i> mycotoxins by UV-C irradiation: Effect of selected process and exposure to food components

Han, Yike; Zhou, Zhongwen; Cao, Zihan; Zong, Wei; Zhao, Genhai; Wang, Xiaoyuan

doi:10.1080/19440049.2022.2151646

Cited by 5 publications

(2 citation statements)

References 52 publications

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“…Alternaria toxins have received an increased research interest in the last few years, enabling the development of advanced and quick detection methods (Han et al 2023a , b ). Fungi belonging to the Alternaria genus produce more than 70 known mycotoxins belonging to three different structural groups: dibenzopyrone derivatives, perylene derivatives, and tetramic acid derivative (Pinto and Patriarca 2017 ).…”

Section: Introductionmentioning

confidence: 99%

The characteristics, occurrence, and toxicological effects of alternariol: a mycotoxin

Saleh,

Zeidan,

Abu-Dieyeh

2024

Arch Toxicol

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Alternaria species are mycotoxin-producing fungi known to infect fresh produce and to cause their spoilage. Humans get exposed to fungal secondary metabolites known as mycotoxin via the ingestion of contaminated food. Alternariol (AOH) (C14H10O5) is an isocoumarins produced by different species of Alternaria including Alternaria alternata. AOH is often found in grain, fruits and fruits-based food products with high levels in legumes, nuts, and tomatoes. AOH was first discovered in 1953, and it is nowadays linked to esophagus cancer and endocrine disruption due to its similarity to estrogen. Although considered as an emerging mycotoxin with no regulated levels in food, AOH occurs in highly consumed dietary products and has been detected in various masked forms, which adds to its occurrence. Therefore, this comprehensive review was developed to give an overview on recent literature in the field of AOH. The current study summarizes published data on occurrence levels of AOH in different food products in the last ten years and evaluates those levels in comparison to recommended levels by the regulating entities. Such surveillance facilitates the work of health risk assessors and highlights commodities that are most in need of AOH levels regulation. In addition, the effects of AOH on cells and animal models were summarized in two tables; data include the last two-year literature studies. The review addresses also the main characteristics of AOH and the possible human exposure routes, the populations at risk, and the effect of anthropogenic activities on the widespread of the mycotoxin. The commonly used detection and control methods described in the latest literature are also discussed to guide future researchers to focus on mitigating mycotoxins contamination in the food industry. This review aims mainly to serve as a guideline on AOH for mycotoxin regulation developers and health risk assessors.

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Section: Introductionmentioning

confidence: 99%

The characteristics, occurrence, and toxicological effects of alternariol: a mycotoxin

Saleh,

Zeidan,

Abu-Dieyeh

2024

Arch Toxicol

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“…Extensive literature has demonstrated that AOH and AME exhibit carcinogenicity, teratogenicity, mutagenicity, genotoxicity, as well as reproductive and developmental toxicity (Wang et al, 2020), which have been proven to persistently contaminate food items with limited removal options once introduced (Luo et al, 2018). Currently employed methods for controlling Alternaria mycotoxins include UV light exposure, inactivated yeast powder treatment, ozone application among others (Han et al, 2023;Wang et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Effects and mechanisms of jujube juice components on degradation of Alternaria mycotoxin by cold plasma

Wang,

Liu,

Han

et al. 2024

Preprint

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The study examined the impact of jujube constituents on cold plasma (CP) degradation of alternariol (AOH) and alternariol monomethyl ether (AME), followed by assessing changes in CP electrochemical properties. The correlation between these properties and toxin degradation was analyzed to understand how jujube components influence the breakdown of AOH and AME. Results showed that when treated with CP for 3 minutes, 0.00350 mg/mL jujube protein degraded 49.0% of AOH and 48.8% of AME. Under the same treatment time, 0.0500 mg/mL jujube polysaccharide degraded AOH by 74.6% and AME by 95.8%. Conversely, Vc, K+, Ca2+, oleic acid, and linoleic acid exhibited negligible inhibitory effects on toxin degradation. Furthermore, following CP treatment, oxidation-reduction potential (△ORP), pH, conductivity, hydrogen peroxide (H2O2), hydroxyl radical (•OH), nitrate ion (NO3−), and nitrite ion (NO2−) contents in the jujube protein or polysaccharide system were significantly correlated with toxin degradation; thus confirming their association with reactive oxygen-nitrogen species (RONS). The presence of jujube protein or polysaccharide hindered the degradation of CP-mediated toxins by consuming reactive RONS resources. This study provides insights into how AOH and AME in jujube juice are degraded by CP, enabling more targeted and efficient elimination of foodborne toxins.

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Alternaria mycotoxins in food and feed: Occurrence, biosynthesis, toxicity, analytical methods, control and detoxification strategies

Nagda,

Meena

2024

Food Control

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Degradation of Alternaria mycotoxins by UV-C irradiation: Effect of selected process and exposure to food components

Cited by 5 publications

References 52 publications

The characteristics, occurrence, and toxicological effects of alternariol: a mycotoxin

The characteristics, occurrence, and toxicological effects of alternariol: a mycotoxin

Effects and mechanisms of jujube juice components on degradation of Alternaria mycotoxin by cold plasma

Alternaria mycotoxins in food and feed: Occurrence, biosynthesis, toxicity, analytical methods, control and detoxification strategies

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