Degradation of doxorubicin to non-toxic metabolites using Fe-Ni bimetallic nanoparticles

Kadu, Brijesh S.; Wani, Kirtee; Kaul-Ghanekar, Ruchika; Chikate, Rajeev C.

doi:10.1016/j.cej.2017.05.097

Cited by 47 publications

(4 citation statements)

References 40 publications

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“…Further analyzing the results of the positive and negative modes of high-resolution mass spectrometry spectra (Figures S5,S6, Supporting Information), the presence of a serial of DOX fragments containing polyhydroxyl groups (polyols) was confirmed. A plausible degradation mechanism of DOX was proposed with the references of previous reports (Figure S7, Supporting Information), [14] and could be possibly related to in situ generated ROS during the ultrasonication of LM. However, no degradation of DOX occurred in absolute ethanol due to the deprivation of the corrosion reaction between Ga and water, and the average size of resultant LMNDs exceeds 60 nm upon 10 min sonication in an ice bath or at room temperature (Figures S8,S9, Supporting Information).…”

Section: Design Synthesis and Characterizations Of Aqueous Small Lmndssupporting

confidence: 59%

Activating Tumor‐Selective Liquid Metal Nanomedicine through Galvanic Replacement

Yan,

Wang,

Wang

et al. 2023

Advanced Materials

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Advanced chemotherapeutic strategies including prodrug and nanocatalytic medicine have significantly advanced tumor‐selective theranostics, but delicate prodrug screening, tedious synthesis, low degradability/biocompatibility of inorganic components and unsatisfied reaction activity complicate treatment efficacies. Here we explore intrinsic anticancer bioactivity of liquid metal nanodroplet (LMND) through the galvanic replacement. By utilizing a mechano‐degradable ligand, the resultant size of aqueous LMND is unexpectedly controlled as small as ∼20 nm (LMND20). We demonstrate that LMND20 presents excellent tumor penetration and biocompatibility and activates tumor‐selective carrier‐to‐drug conversion, synchronously depleting Cu2+ ions and producing Ga3+ ions through the galvanic replacement. Together with abundant generation of reactive oxygen species, multiple anticancer pathways lead to selective apoptosis and anti‐angiogenesis of breast cancer cells. Compared to the preclinical/clinical anticancer drugs of tetrathiomolybdate and Ga(NO3)3, LMND20 administration significantly improves the therapeutic efficacy and survival in a BCap‐37 xenograft mouse model, yet without obvious side effects.This article is protected by copyright. All rights reserved

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Section: Design Synthesis and Characterizations Of Aqueous Small Lmndssupporting

confidence: 59%

Activating Tumor‐Selective Liquid Metal Nanomedicine through Galvanic Replacement

Yan,

Wang,

Wang

et al. 2023

Advanced Materials

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“…Wheat strawsupported nZVI composites were successfully used to remove chlortetracycline and copper ions through redox reaction and adsorption process in aqueous solution; thereby, providing new insights to the remediation of complex wastewater (Shao et al, 2020). Many researchers have shown that Fe-Ni is a suitable BNP for degradation of various therapeutics, such as tetracycline and doxorubicin (Kadu et al, 2017;Dong et al, 2018b). Fe-Cu BNPs has also been used for the efficient removal of oxytetracycline in the past (Wu et al, 2018).…”

Section: H I G H L I G H T Smentioning

confidence: 99%

In situ formation of bimetallic FeNi nanoparticles on sand through green technology: Application for tetracycline removal

Ravikumar

Ghosh

Pulimi

et al. 2019

Front. Environ. Sci. Eng.

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In this study, FeNi nanoparticles were green synthesized using Punica granatum (pomegranate) peel extract, and these nanoparticles were also formed in situ over quartz sand (GS-FeNi) for removal of tetracycline (TC). Under the optimized operating conditions, (GS-FeNi concentration: 1.5% w/v; concentration of TC: 20 mg/L; interaction period: 180 min), 99AE0.2% TC removal was achieved in the batch reactor. The removal capacity was 181AE1 mg/g. A detailed characterization of the sorbent and the solution before and after the interaction revealed that the removal mechanism(s) involved both the sorption and degradation of TC. The reusability of reactant was assessed for four cycles of operation, and 77AE4% of TC removal was obtained in the cycle. To judge the environmental sustainability of the process, residual toxicity assay of the interacted TC solution was performed with indicator bacteria (Bacillus and Pseudomonas) and algae (Chlorella sp.), which confirmed a substantial decrease in the toxicity. The continuous column studies were undertaken in the packed bed reactors using GS-FeNi. Employing the optimized conditions, quite high removal efficiency (978AE5 mg/g) was obtained in the columns. The application of GS-FeNi for antibiotic removal was further evaluated in lake water, tap water, and ground water spiked with TC, and the removal capacity achieved was found to be 781AE5, 712AE5, and 687AE3 mg/g, respectively. This work can pave the way for treatment of antibiotics and other pollutants in the reactors using novel green composites prepared from fruit wastes.

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“…Doxorubicin (DOX) is one of the potent chemotherapeutic agents used in the management of both haematopoietic and solid malignant tumours of different origin [ 1 – 3 ]. In the past two decades, its application by oncologists has been extensively explored, although its continuous usage alone in clinical settings is impeded due to its life-threatening effect on organs such as heart, kidney, and liver [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Toxicity and Safety Evaluation of Doxorubicin-Loaded Cockleshell-Derived Calcium Carbonate Nanoparticle in Dogs

Danmaigoro

Selvarajah

Noor

et al. 2018

Advances in Pharmacological Sciences

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Doxorubicin (DOX) is a potent anticancer agent with cytotoxic effects which limit its clinical usage. This effect is due to its nonselective nature causing injury to the cells as a result of reactive free oxygen radical's release. Cockleshell-derived calcium carbonate nanoparticle (CS-CaCO3NP) is a pH-responsive carrier with targeted delivery potentials. This study aimed at evaluating the toxicity effects of repeated dose administration of DOX-loaded CS-CaCO3NP in healthy dogs. Fifteen dogs with an average body weight of 15 kg were randomized equally into 5 groups. Dogs were subjected to 5 doses at every 3-week interval with (i) normal saline, (ii) DOX, 30 mg/m2, and the experimental groups: CS-CaCO3NP-DOX at (iii) high dose, 50 mg/m2, (iv) clinical dose, 30 mg/m2, and (v) low dose, 20 mg/m2. Radiographs, electrocardiography, and blood samples were collected before every treatment for haematology, serum biochemistry, and cardiac injury assessment. Heart and kidney tissues were harvested after euthanasia for histological and ultrastructural evaluation. The cumulative dose of DOX 150 mg/m2 over 15 weeks revealed significant effects on body weight, blood cells, functional enzymes, and cardiac injury biomarkers with alterations in electrocardiogram, myocardium, and renal tissue morphology. However, the dogs given CS-CaCO3NP-DOX 150 mg/m2 and below did not show any significant change in toxicity biomarker as compared to those given normal saline. The study confirmed the safety of repeated dose administration of CS-CaCO3NP-DOX (30 mg/m2) for 5 cycles in dogs. This finding offers opportunity to dogs with cancer that might require long-term administration of DOX without adverse effects.

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Degradation of doxorubicin to non-toxic metabolites using Fe-Ni bimetallic nanoparticles

Cited by 47 publications

References 40 publications

Activating Tumor‐Selective Liquid Metal Nanomedicine through Galvanic Replacement

Activating Tumor‐Selective Liquid Metal Nanomedicine through Galvanic Replacement

In situ formation of bimetallic FeNi nanoparticles on sand through green technology: Application for tetracycline removal

Toxicity and Safety Evaluation of Doxorubicin-Loaded Cockleshell-Derived Calcium Carbonate Nanoparticle in Dogs

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