Degradation of doxorubicin and daunorubicin in human and rabbit biological fluids

Maniez-Devos, Dominique M.; Baurain, R.; Lesne, Michel; Trouet, André

doi:10.1016/0731-7085(86)80057-7

Cited by 16 publications

(10 citation statements)

References 14 publications

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“…In this case, the greater toxicity of NP-TA-Dox may be attributed to the stability of Dox bound to NP-TA relative to free Dox, which has a short half-life in biological fluid at 37 °C. 57 4T1 cells showed a similar trend as MCF7 cells although the difference was insignificant. In any cases, the effect of NP-TA itself would be negligible because it showed <20% effect at the highest level of NPs.…”

Section: Discussionmentioning

confidence: 66%

Tannic Acid-Mediated Surface Functionalization of Polymeric Nanoparticles

Abouelmagd

Meng

Kim

et al. 2016

ACS Biomater. Sci. Eng.

112

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Polymeric nanoparticles (NPs) are decorated with various types of molecules to control their functions and interactions with specific cells. We previously used polydopamine (pD) to prime-coat poly(lactic-co-glycolic acid) (PLGA) NPs and conjugated functional ligands onto the NPs via the pD coating. In this study, we report tannic acid (TA) as an alternative prime coating that is functionally comparable to pD but does not have drawbacks of pD such as optical properties and interference of ligand characterization. TA forms a stable and optically inert coating on PLGA NPs, which can accommodate albumin, chitosan, and folate-terminated polyethylene glycol to control the cell-NP interactions. Moreover, TA coating allows for surface loading of polycyclic planar aromatic compounds. TA is a promising reactive intermediate for surface functionalization of polymeric NPs.

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Section: Discussionmentioning

confidence: 66%

Tannic Acid-Mediated Surface Functionalization of Polymeric Nanoparticles

Abouelmagd

Meng

Kim

et al. 2016

ACS Biomater. Sci. Eng.

112

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“…27,28 To confirm the presence of DNR in excised rabbit vitreous following incubation with DNR-loaded pSi particles at 37°C, an 8-day ex vivo study was performed, considering that beyond that time excised vitreous would alter substantially even decomposing. For this study, 3 mg of drug-loaded pSi microparticles in 100 mL of a balanced salt solution (BSS; Gibco, Carslbad, CA) was injected into a 1.5 mL excised rabbit vitreous in a vial using a 25-gauge needle.…”

Section: Ex Vivo Dnr Confirmation In Rabbit Vitreousmentioning

confidence: 99%

“…This is a major factor influencing the pharmacokinetics of these anthracycline drugs in vivo. 27 Of the possible DNR degradation products, semiquinone-free radicals produced from reduction of the quinone group of DNR are cytotoxic, and this may be one of the chemical pathways by which DNR exerts its effect against unwanted cellular proliferation. In our previous in vitro study, reduced DNR was observed, and the degradation products from this hydrosilylated pSi delivery system showed increased potency toward RPE cells.…”

mentioning

confidence: 99%

Hydrosilylated Porous Silicon Particles Function as an Intravitreal Drug Delivery System for Daunorubicin

Hartmann

Nieto²,

Wu³

et al. 2013

Journal of Ocular Pharmacology and Therapeutics

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“…Unfortunately, many of the results of stability studies with doxorubicin were found to be at variance with each other, with a 20-fold difference in stability [1]. It is also clear that anthracydines are sensitive to light [6], degrade with increasing temperature [2,[7][8] and adsorb to membrane filters and containers except polypropylene and siliconised glass [7]. Obviously, anthracyclines are stable in plasma for longer periods of time when stored at 80 ~ [5].…”

Section: Introductionmentioning

confidence: 99%