Degradation of covalently cross-linked carboxymethyl chitosan and its potential application for peripheral nerve regeneration

Lu, Guangyuan; Kong, Lijun; Sheng, Baiyang; Wang, Gan; Gong, Yandao; Zhang, Xiufang

doi:10.1016/j.eurpolymj.2007.06.016

Cited by 160 publications

(91 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…GR activity was decreased in serum and mitochondria of kidney by 4.12% and 2.89%, respectively, and increased in mitochondria of liver and spleen by 6.02% and 1.45%, respectively, due to CMC-EDBE-FA administration as compared to control that are not significant (P<0.05). CMC-EDBE-FA supplementation to nicotine treated mice increased GR activity significantly in serum and mitochondria of liver, kidney and spleen by 66.57%, 64.9%, 23.85% and 188.16%, respectively (P<0.05) (Figure 10).…”

Section: Activity Of Glutathione Reductasementioning

confidence: 78%

“…CMC is a water-soluble and biodegradable polymer. Amino and carboxyl functional group of CMC can serve as chelation sites and form complexes with pharmaceuticals [6] . CMC is often used as a pharmaceutical excipient because it offers the advantage of easy chemical modifications due to the primary amino group at the C 2 -position and the carboxyl group at the C 6 -position of each polymer subunit [7,8] .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antioxidative effect of folate–modified chitosan nanoparticles

Chakraborty

Mahapatra

Sahu

et al. 2011

Asian Pacific Journal of Tropical Biomedicine

View full text Add to dashboard Cite

Section: Activity Of Glutathione Reductasementioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Antioxidative effect of folate–modified chitosan nanoparticles

Chakraborty

Mahapatra

Sahu

et al. 2011

Asian Pacific Journal of Tropical Biomedicine

View full text Add to dashboard Cite

“…Cell viability was assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT reduction), as previously described (Lu et al 2007). Briefly, MTT was added at a final concentration of 1 mg/mL into serum-free medium and incubated for 2 h in a CO 2 incubator at 37°C.…”

Section: Cell Viabilitymentioning

confidence: 99%

Edaravone protects human peripheral blood lymphocytes from γ-irradiation-induced apoptosis and DNA damage

Chen

Liu

Dong

et al. 2015

Cell Stress and Chaperones

View full text Add to dashboard Cite

Radiation-induced cellular injury is attributed primarily to the harmful effects of free radicals, which play a key role in irradiation-induced apoptosis. In this study, we investigated the radioprotective efficacy of edaravone, a licensed clinical drug and a powerful free radical scavenger that has been tested against γ-irradiation-induced cellular damage in cultured human peripheral blood lymphocytes in studies of various diseases. Edaravone was pre-incubated with lymphocytes for 2 h prior to γ-irradiation. It was found that pretreatment with edaravone increased cell viability and inhibited generation of γ-radiation-induced reactive oxygen species (ROS) in lymphocytes exposed to 3 Gy γ-radiation. In addition, γ-radiation decreased antioxidant enzymatic activity, such as superoxide dismutase and glutathione peroxidase, as well as the level of reduced glutathione. Conversely, treatment with 100 μM edaravone prior to irradiation improved antioxidant enzyme activity and increased reduced glutathione levels in irradiated lymphocytes. Importantly, we also report that edaravone reduced γ-irradiation-induced apoptosis through downregulation of Bax, upregulation of Bcl-2, and consequent reduction of the Bax:Bcl-2 ratio. The current study shows edaravone to be an effective radioprotector against γ-irradiation-induced cellular damage in lymphocytes in vitro. Finally, edaravone pretreatment significantly reduced DNA damage in γ-irradiated lymphocytes, as measured by comet assay (% tail DNA, tail length, tail moment, and olive tail moment) (p<0.05). Thus, the current study indicates that edaravone offers protection from radiation-induced cytogenetic alterations.

show abstract

“…Due to the NH 2 and OH functional groups that can serve as conjunction sites, chitosan is a good sorbent with high affinity for transition metal ions [7]. Chitosan has good film forming ability, porous scaffolds, and hydrogels [8]. Ion-conducting polymer electrolytes based on chitosan have also been reported [9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Electrical Conduction Mechanism in Solid Polymer Electrolytes: New Concepts to Arrhenius Equation

Aziz

Abidin

2013

Journal of Soft Matter

107

View full text Add to dashboard Cite

Solid polymer electrolytes based on chitosan NaCF 3 SO 3 have been prepared by the solution cast technique. X-ray diffraction shows that the crystalline phase of the pure chitosan membrane has been partially disrupted. The fourier transform infrared (FTIR) results reveal the complexation between the chitosan polymer and the sodium triflate (NaTf) salt. The dielectric constant and DC conductivity follow the same trend with NaTf salt concentration. The increase in dielectric constant at different temperatures indicates an increase in DC conductivity. The ion conduction mechanism follows the Arrhenius behavior. The dependence of DC conductivity on both temperature and dielectric constant ( dc ( , ) = 0 − / ) is also demonstrated.

show abstract

Degradation of covalently cross-linked carboxymethyl chitosan and its potential application for peripheral nerve regeneration

Cited by 160 publications

References 33 publications

Antioxidative effect of folate–modified chitosan nanoparticles

Antioxidative effect of folate–modified chitosan nanoparticles

Edaravone protects human peripheral blood lymphocytes from γ-irradiation-induced apoptosis and DNA damage

Electrical Conduction Mechanism in Solid Polymer Electrolytes: New Concepts to Arrhenius Equation

Contact Info

Product

Resources

About