Degradation of copolymers obtained by ring-opening polymerization of glycolide and ɛ-caprolactone: A high resolution NMR and ESI-MS study

FTIR and NMR study of poly(lactide-co-glycolide) and hydroxyapatite implant degradation under in vivo conditions

“…These methods are very sensitive and valuable tools for investigation of copolymer structure and its changes during degradation. The usefulness of these methods was confirmed in previous studies of resorbable polymers [7,[16][17][18][19]]. …”

Designing bioresorbable polyester matrices for controlled doxorubicin release in glioma therapy

“…7). For example, the concentration of glycolidyl units (N GG ) decreased insignificantly from 8% to 7% after 126 days, what confirms the resistance of alternate sequences [CapGCap] to degradation, that was presented in our previous papers Kasperczyk et al, 2008b;Kasperczyk, 1999).…”

“…Theoretically, PGLA degrades faster than PGCA with low content of glycolidyl units in copolymer chain (about 10 mol%). Moreover, presence of specific sequences in copolymer chain enables its stable, slow degradation what was confirmed by means of NMR spectroscopy and ESI-MS mass spectrometry (Kasperczyk et al, 2008b). The parameters used to characterize the obtained polymer materials: melting temperature (T m ), glass transition temperature (T g ), molecular weights and polydispersity (GPC) as well as the parameters characterizing the polyester chains microstructure (NMR) were shown in Table 1.…”

Forensic engineering of advanced polymeric materials – Part II: The effect of the solvent-free non-woven fabrics formation method on the release rate of lactic and glycolic acids from the tin-free poly(lactide-co-glycolide) nonwovens

“…Such a microstructure is distinctive of the segmental copolymers, which are obtained during copolymerization initiated with Zr(Acac) 4 conducted in bulk at 110 C [24,25,29,30]. The microblock length for all starting NWMs was approximately 2.0 glycolide units (GG) and 9.7 lactidyl units (LL), as calculated from the 13 C NMR spectra.…”