Degradation of carbon-14 labeled diazinon in the rat

Mücke, W.; Alt, Karl O.; Esser, H. O.

doi:10.1021/jf60168a020

Cited by 48 publications

(14 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…application is such that DZN is rapidly absorbed from the gastrointestinal tract and widely distributed throughout the body in both humans [33] and animals [20] , [30] . Both human and animal data demonstrate rapid metabolism of DZN and its oxon to DEP, DETP, and IMHP, which are predominantly excreted in the urine [13] , [25] , [30] , [33] , [43] , [44] . However, although it is generally thought that organophosphorous pesticides do not accumulate in the organism, being rapidly metabolized to their dialkylphosphates, Garcia-Repetto et al [12] have found an endogenous reintoxication caused by this kind of compound.…”

Section: Discussionmentioning

confidence: 99%

Downregulation of nicotinic and muscarinic receptor function in rats after subchronic exposure to diazinon

et al. 2016

View full text Add to dashboard Cite

HighlightsWe studied the development of tolerance to subchronic p.o. administration of DZN in rats, under both in vivo and in vitro conditionsAs a consequence of AChE inhibition, ACh neurotransmitters are being accumulated in over stimulated nicotinic and muscarinic receptors.With isolated diaphragm and ileum, we examined the down regulation of nicotinic and muscarinic receptor function through EFS technique.The results of our research could be useful in forensic diagnostics of organophosphate poisoning.

show abstract

Section: Discussionmentioning

confidence: 99%

Downregulation of nicotinic and muscarinic receptor function in rats after subchronic exposure to diazinon

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Within 6 hr after birth, offspring were randomized within treatment groups to give each treated or control mother four male and four female pups from a like-treated dam. Cross-fostering procedures were not employed because no deviant maternal-offspring interactions were observed and the rapid excretion of Diazinon by the mother (Mucke et al, 1970) minimized contamination of the milk.…”

Section: Methodsmentioning

confidence: 99%

“…Diazinon and its metabolites are rapidly excreted, mainly in urine; at least 95% of an oral dose in rats is excreted within 168 hr (Mucke et al, 1970). Examination of tissue taken from rats chronically exposed to Diazinon by incorporation in the diet does not reveal pesticide accumulation within any tissue compartment tested (Mucke et al, 1970).…”

Section: Introductionmentioning

confidence: 99%

Neurobehavioral effects of prenatal exposure to the organophosphate Diazinon in mice

Spyker

Avery

1977

Journal of Toxicology and Environmental Health

View full text Add to dashboard Cite

Pregnant mice were given to daily dose of 0, 0.18, or 9.0 mg Diazinon per kilogram body weight throughout gestation. Mothers of all dose groups gave birth to viable, overtly normal offspring. However, pups born to mothers receiving the higher dose of the organophosphate grew significantly slower than controls and remained significantly smaller at 1 month of age. Offspring of mothers receiving the lower dose apparently were unaffected, but systematic behavioral testing revealed subtle deviations from normal developmental ontogeny as shown by significant delays in the appearance of the contact placing reflex and of sexual maturity (descent of testes or vaginal opening). Mature offspring of mothers exposed to either dose of the pesticle displayed impaired endurance and coordination on rod cling and inclined plane tests of neuromuscular function. Offspring from the 9.0 mg/kg group, in addition, had slower running speeds in a Lashley III maze and less endurance in a swimming test. Brains obtained after sacrifice at 101 days of age revealed neuropathology in the forebrains of offspring born of mothers exposed to the higher dose. Despite functional impairments in offspring from the lower dose group, no corresponding brain pathology was observed by examination under the light microscope.

show abstract

“…Compounds (1) and (2), which were detected at retention times of 19.0 and 25.8 min respectively, were identified by comparison with authentic standards as 2-isopropyl-6-methylpyrimidin-4-ol (IMP) and diaz- IMP is the hydrolysis product of diazinon formed through the cleavage of P¢O(pyrimidine group) bond, that has been found in water, soil, plants, and animals [9,29]. Diazoxon (Mr 288), the oxygen analogue of diazinon in which S has been replaced by an O atom, has been reported to be a diazinon photolysis product in water/soil suspensions [9] and is a diazinon metabolite formed in vitro and in vivo in studies with animals [30].…”

Section: Gc/msmentioning

confidence: 99%

Identification of photocatalytic degradation products of diazinon in TiO₂aqueous suspensions using GC/MS/MS and LC/MS with quadrupole time-of-flight mass spectrometry

Kouloumbos¹,

Tsipi²,

Hiskia

et al. 2003

J. Am. Soc. Mass Spectrom.

130

View full text Add to dashboard Cite

The photocatalytic degradation of the organophosphorus insecticide diazinon in aqueous suspensions has been studied by using titanium dioxide as a photocatalyst. The degradation of the insecticide was a fast process and included the formation of several intermediates that were identified using GC/ion-trap mass spectrometry with EI or CI in positive and negative ionization mode and HPLC/electrospray-QqTOF mass spectrometry. Since primarily hydroxy derivatives were identified in these aqueous suspensions, the mechanism of degradation was probably based on hydroxyl radical attack. The initial oxidative pathways of the degradation of diazinon involved the substitution of sulfur by oxygen on the P¢S bond, cleavage of the pyrimidine ester bond, and oxidation of the isopropyl group. Exact mass measurements of the derivatives allowed the elemental formula of the molecules to be determined confidently. Similarities to the metabolic pathways occurring in living organisms were observed. (J Am Soc Mass Spectrom 2003, 14, 803-817)

show abstract

Degradation of carbon-14 labeled diazinon in the rat

Cited by 48 publications

References 11 publications

Downregulation of nicotinic and muscarinic receptor function in rats after subchronic exposure to diazinon

Downregulation of nicotinic and muscarinic receptor function in rats after subchronic exposure to diazinon

Neurobehavioral effects of prenatal exposure to the organophosphate Diazinon in mice

Identification of photocatalytic degradation products of diazinon in TiO₂aqueous suspensions using GC/MS/MS and LC/MS with quadrupole time-of-flight mass spectrometry

Contact Info

Product

Resources

About

Degradation of carbon-14 labeled diazinon in the rat

Cited by 48 publications

References 11 publications

Downregulation of nicotinic and muscarinic receptor function in rats after subchronic exposure to diazinon

Downregulation of nicotinic and muscarinic receptor function in rats after subchronic exposure to diazinon

Neurobehavioral effects of prenatal exposure to the organophosphate Diazinon in mice

Identification of photocatalytic degradation products of diazinon in TiO2aqueous suspensions using GC/MS/MS and LC/MS with quadrupole time-of-flight mass spectrometry

Contact Info

Product

Resources

About

Identification of photocatalytic degradation products of diazinon in TiO₂aqueous suspensions using GC/MS/MS and LC/MS with quadrupole time-of-flight mass spectrometry