Degradation of angiotensin II by plasmin

Dudek, G; Latałło, Z; Prokopowicz, J; Worowski, K

doi:10.1111/j.1476-5381.1972.tb09576.x

Cited by 2 publications

(1 citation statement)

References 15 publications

(13 reference statements)

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“…The fibrinolysis-activating effect of protamine may be the cause of some clinical disturbances such as a fall in blood pressure and bradycardia [1]. The relationship between activation of fibrinolysis and hypotension seems to have been proved [3,16]. The release of basic proteins from damaged cells or tissues into the blood circulation can also produce similar effects [7].…”

Section: Discussionmentioning

confidence: 99%

The Inhibition of Proteolytic Enzymes by Protamine in Dependence on the Type of Substrate

Worowski¹,

Rzeczycki²,

Mariak³

1972

Enzyme

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The inhibitory effect of protamine on the fibrinogenolytic and fibrinolytic activities of plasmin, trypsin and Chymotrypsin A was studied. While the clot fibrinolysis was inhibited by protamine in the presence of the three enzymes, a marked inhibition of the proteolysis of fibrinogen and fibrin was observed only in the presence of Chymotrypsin, a lesser degree of inhibition being observed when plasmin and trypsin were used. The fibrinolysis-inhibiting effect of protamine is brought about by the formation of fibrin-protamine complexes and changes in the clot structure. The structural changes of fibrinogen and fibrin are responsible for their inhibited proteolysis. In the unpurified systems, protamine inhibits fibrinolysis only when the plasma is highly diluted. In the undiluted plasma, quite opposite effects of protamine were observed - that is, fibrinolysis activation probably brought about by the neutralization of plasma antiplasmins by protamine.

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Section: Discussionmentioning

confidence: 99%

The Inhibition of Proteolytic Enzymes by Protamine in Dependence on the Type of Substrate

Worowski¹,

Rzeczycki²,

Mariak³

1972

Enzyme

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Renin–Angiotensin–Aldosterone System and the Renal Regulation of Sodium, Potassium, and Blood Pressure Homeostasis

Laragh

Sealey

1992

Comprehensive Physiology

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The sections in this article are: Historical Background Renin Aldosterone A Coordinated Renal‐Adrenal Hormonal System: Renin, Angiotensin, and Aldosterone Comparative Aspects Brief Overview of the Renin‐Angiotensin‐Aldosterone System Biochemistry and Molecular Biology of the Renin System Prorenin Renin Renin Substrate Angiotensins I and II Angiotensin‐Converting Enzyme Aldosterone Methods of Measurement Physiology Prorenin Renin Renin Substrate Angiotensin II Aldosterone Cybernetics of the System Coordinated Regulation of Sodium, Potassium, and Blood Pressure Use of the Renin System to Understand Blood Pressure Control and Disorders of Pressure‐Volume Homeostasis Two Forms of Vasoconstriction: Vasoconstriction‐Volume Analysis Three Basic Tenets Concerning Plasma Renin Measurements The Sodium—Calcium Connection Dynamic Reciprocity of Two Forms of Vasoconstriction The Sympathetic Nervous System and Modulation of the Two Forms of Arteriolar Vasoconstriction Human Disorders of the Renin System Hypertensive Disorders Renin System Abnormalities in Edematous States Hypokalemic Normotensive States Summary

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Degradation of angiotensin II by plasmin

Cited by 2 publications

References 15 publications

The Inhibition of Proteolytic Enzymes by Protamine in Dependence on the Type of Substrate

The Inhibition of Proteolytic Enzymes by Protamine in Dependence on the Type of Substrate

Renin–Angiotensin–Aldosterone System and the Renal Regulation of Sodium, Potassium, and Blood Pressure Homeostasis

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