Degradation of albumin by the renal proximal tubule cells and the subsequent fate of its fragments

Gudehithlu, Krishnamurthy P.; Pegoraro, Alfredo A.; Dunea, George; Arruda, José A.L.; Singh, Ashok K.

doi:10.1111/j.1523-1755.2004.00633.x

Cited by 77 publications

(75 citation statements)

References 20 publications

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“…This observation, together with the disproportionately higher protection from UAV in our congenic animals, suggests that the Rab38 gene might affect the reabsorption and degradation of filtered proteins by proximal tubular cells. Indeed, the mechanism of tubular reuptake and protein metabolism involves extensive trafficking of vesicles carrying protein receptors and their ligands from the apical membrane to the lysosomes (12,22,26).…”

Section: Discussionmentioning

confidence: 99%

Rf-2 Gene Modulates Proteinuria and Albuminuria Independently of Changes in Glomerular Permeability in the Fawn-Hooded Hypertensive Rat

Rangel-Filho

Sharma²,

Datta

et al. 2005

Journal of the American Society of Nephrology

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Section: Discussionmentioning

confidence: 99%

Rf-2 Gene Modulates Proteinuria and Albuminuria Independently of Changes in Glomerular Permeability in the Fawn-Hooded Hypertensive Rat

Rangel-Filho

Sharma²,

Datta

et al. 2005

Journal of the American Society of Nephrology

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“…Molecules below albumin molecular size (68 kDa) constitutively pass the kidney glomerular filter and are reabsorbed by tubular epithelial cells (37,38). kDCs have recently been shown to take up filterable 40-kDa and nonfilterable 500-kDa dextran molecules (33).…”

Section: Kdcs Preferentially Endocytose Filterable Agmentioning

confidence: 99%

The Kidney-Renal Lymph Node-System Contributes to Cross-Tolerance against Innocuous Circulating Antigen

Lukacs‐Kornek

Burgdorf

Diehl

et al. 2008

The Journal of Immunology

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Soluble Ags devoid of inflammatory stimuli, derived for example from self-serum or food proteins, induce T cell tolerance, predominantly in the spleen. In this study, we describe an additional role of the kidney-renal LN (rLN) system in tolerogenic presentation of circulating soluble Ags. Protein below albumin molecular mass constitutively passed the kidney glomerular filter and was concentrated in the tubular compartment. Enriched filterable Ag was endocytosed by kidney dendritic cells (kDCs). Simultaneously, it was transported cell independently within 2 min to DCs resident in rLNs. These DC phenotypically differed from kDCs carrying filterable Ag, and used a distinct mechanism, mannose receptor-mediated endocytosis, to internalize Ag. They activated specific CD8+ T cells, which subsequently proliferated without producing effector cytokines or developing cytotoxic activity, showed a curtailed lifespan and signs of apoptosis. Such T cell tolerization was independent of steady-state migratory kDC, because it occurred also when nephrectomy was performed soon after Ag injection. These findings demonstrate that the kidney dispatches concentrated blood-borne Ags to the rLNs, where they are captured by resident DCs, resulting in CD8+ T cell cross-tolerance. This mechanism may contribute to avoiding immunity against innocuous circulating protein Ags below albumin size.

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“…Until recently, studies have shown that large quantities of peptides also appeared in urine [30,42]. However, the composition of the peptides in urine is not clearly understood.…”

Section: Extraction Of the Peptides From Urinementioning

confidence: 99%

Analysis of the human urine endogenous peptides by nanoparticle extraction and mass spectrometry identification

Yang

et al. 2014

Analytica Chimica Acta

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Degradation of albumin by the renal proximal tubule cells and the subsequent fate of its fragments

Abstract: We conclude that normally the kidney degrades large amounts of albumin and that the degradation fragments appear in the urine. These findings are in sharp contrast with the established view that degraded albumin is completely reabsorbed into the blood stream.

Cited by 77 publications

References 20 publications

Rf-2 Gene Modulates Proteinuria and Albuminuria Independently of Changes in Glomerular Permeability in the Fawn-Hooded Hypertensive Rat

Rf-2 Gene Modulates Proteinuria and Albuminuria Independently of Changes in Glomerular Permeability in the Fawn-Hooded Hypertensive Rat

The Kidney-Renal Lymph Node-System Contributes to Cross-Tolerance against Innocuous Circulating Antigen

Analysis of the human urine endogenous peptides by nanoparticle extraction and mass spectrometry identification

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