Degradation mechanisms and acceleration strategies of poly (lactic acid) scaffold for bone regeneration

Biomimetic, mussel-inspired surface modification of 3D-printed biodegradable polylactic acid scaffolds with nano-hydroxyapatite for bone tissue engineering

“…Meanwhile, the pH variation during 28 days of immersion time was recorded. Proverbially, the acidic environments produced during the biodegradation of PLA scaffolds might cause a local immune response, which is a detrimental factor for bone regeneration ( Feng et al, 2021 ; Shuai et al, 2021 ). The results from the present immersion test revealed that the nHA coating layer greatly neutralized the acidic by-products produced during the degradation process of the PLA scaffold, and such trends became more evident with the increasing amount of HA nanoparticles on the surface.…”

“…Generally, biodegradation of bone grafting substitutes is achieved during the repair of bone defects, which requires a consistent rate between new bone formation and artificial implant scaffold degradation (Bose et al, 2012). Although 3Dprinted PLA-based scaffolds are biodegradable, the degradation process is deemed to be too slow (2-3 years) to match the rate of in vivo new bone formation (8-12 weeks) (Feng et al, 2021). Theoretically, in a physiological environment, the PLA-based implant scaffold is mainly degraded by the action of water Frontiers in Bioengineering and Biotechnology frontiersin.org molecules (Feng et al, 2021).…”

“…Although 3Dprinted PLA-based scaffolds are biodegradable, the degradation process is deemed to be too slow (2-3 years) to match the rate of in vivo new bone formation (8-12 weeks) (Feng et al, 2021). Theoretically, in a physiological environment, the PLA-based implant scaffold is mainly degraded by the action of water Frontiers in Bioengineering and Biotechnology frontiersin.org molecules (Feng et al, 2021). In the present study, enhanced biodegradable properties were achieved by introducing HA nanoparticles to the surface of 3D printed PLA scaffolds, as evidenced by Figure 7.…”

Characterisation of Enzyme Catalysed Hydrolysation Stage of Poly(Lactic Acid) Fibre Surface by Nanoscale Thermal Analysis: New Mechanistic Insight

“…Among others, bio-based poly(lactic acid) (PLA), has been well established in industrial scale [14]. As a biodegradable polymer [15][16][17] derived from renewable sources, e.g. sugar, starch, PLA can be processed on all standard thermoplastic converting machines with minor modification and increasingly finds applications in biomedical area [16][17][18], but also in consumer goods, packaging and fibres [19].…”

“…As a biodegradable polymer [15][16][17] derived from renewable sources, e.g. sugar, starch, PLA can be processed on all standard thermoplastic converting machines with minor modification and increasingly finds applications in biomedical area [16][17][18], but also in consumer goods, packaging and fibres [19]. Furthermore, PLA is also recognised as a promising material to reduce the societal solid waste disposal problem due to its biodegradability potential as the pollution from water process in textile industry has been very concerned [15,20].…”