Degradation mechanism of poly(lactic-co-glycolic) acid block copolymer cast films in phosphate buffer solution

Vey, Elisabeth; Roger, Caroline; Meehan, Liz; Booth, Jonathan; Claybourn, Mike; Miller, Aline F.; Saiani, Alberto

doi:10.1016/j.polymdegradstab.2008.07.018

Cited by 87 publications

(83 citation statements)

References 40 publications

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“…In Figure 10B, the homogenous, heterogeneous, and transition regimes predicted in the current study are compared to experimental observations of homogenous and heterogeneous diffusion in different sized samples (Chen et al, 1997;Grizzi et al, 1995;Lu et al, 1999;Park, 1995;Shirazi et al, 2014;Spenlehauer et al, 1989;Vey et al, 2008). Grizzi et al (1995) has proposed a range of 200-300 μm as a critical thickness above which the poly(D,L-lactic acid) polymers (plate, film, microsphere)(which have a similar chemical structure and degradation behaviour to PLGA) undergo heterogeneous degradation.…”

Section: Discussionmentioning

confidence: 72%

“…Grizzi et al (1995) has proposed a range of 200-300 μm as a critical thickness above which the poly(D,L-lactic acid) polymers (plate, film, microsphere)(which have a similar chemical structure and degradation behaviour to PLGA) undergo heterogeneous degradation. The heterogeneous degradation of PLGA films with thicknesses of 300 μm, 250 μm, and 5-100 μm has been shown by Vey et al (2008), Shirazi et al (2014), and Lu et al (1999), respectively. Spenlehauer et al (1989) has showed that PLGA microspheres less than 200 μm in diameter undergo a homogeneous degradation.…”

Section: Discussionmentioning

confidence: 99%

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Modelling the degradation and elastic properties of poly(lactic-co-glycolic acid) films and regular open-cell tissue engineering scaffolds

Shirazi

Ronan

Rochev

et al. 2016

Journal of the Mechanical Behavior of Biomedical Materials

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Publication InformationShirazi, RN,Ronan, W,Rochev, Y,McHugh, P (2016) 'Modelling the degradation and elastic properties of poly (lacticco-glycolic AbstractScaffolding plays a critical rule in tissue engineering and an appropriate degradation rate and sufficient mechanical integrity are required during degradation and healing of tissue. This paper presents a computational investigation of the molecular weight degradation and the mechanical performance of poly(lactic-co-glycolic acid) (PLGA) films and tissue engineering scaffolds. A reactiondiffusion model which predicts the degradation behaviour is coupled with an entropy-based mechanical model which relates the Young's modulus and the molecular weight. The model parameters are determined based on experimental data for in-vitro degradation of a PLGA film. Microstructural models of three different scaffold architectures are used to investigate the degradation and mechanical behaviour of each scaffold. Although the architecture of the scaffold does not have a significant influence on the degradation rate, it determines the initial stiffness of the scaffold. It is revealed that the size of the scaffold strut controls the degradation rate and the mechanical collapse. A critical length scale due to competition between diffusion of degradation products and autocatalytic degradation is determined to be in the range 2-100 μm. Below this range, slower homogenous degradation occurs; however, for larger samples monomers are trapped inside the sample and faster autocatalytic degradation occurs.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Modelling the degradation and elastic properties of poly(lactic-co-glycolic acid) films and regular open-cell tissue engineering scaffolds

Shirazi

Ronan

Rochev

et al. 2016

Journal of the Mechanical Behavior of Biomedical Materials

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“…Simulations are run for random scission and end scission of a random initial polymer chain distribution, which is generated by 99 random scissions of an initial chain containing 150000 units. The reported maximum length of water-soluble chains varies in the literature [7,[9][10][11][12] so this study considers values of 7, 11, or 15 polymer units. The average initial values of molecular weight are M n ≈109000 and M w ≈214000 g/mol.…”

Section: Case Study 3: Prediction Of the Water-soluble Fraction Of Dementioning

confidence: 99%

“…As a result, it may be most appropriate for theoretical calculations of molecular weight to exclude chains below a certain length. It may also be the case that water-soluble chains can diffuse out of the polymer [9] in which case, they would be excluded from GPC analysis. In this paper, a numerical simulation tool is presented that can simulate random scission and end scission of polymer chains.…”

Section: Introductionmentioning

confidence: 99%

Computer Simulation of Polymer Chain Scission in Biodegradable Polymers

Gleadall¹

2013

J Biotechnol Biomater

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Biodegradable polymers degrade due to the hydrolysis (chain scission) of the polymer chains. Two theories of hydrolysis are that 1) scissions occur randomly at any bond in chains, and 2) scissions occur in the final bond at chain ends. In this study, a simulation tool was developed to simulate both random chain scission and chain end scission. The effect of each type of scission was analysed. Random scissions were found to have over 1000 time's greater impact on molecular weight reduction than end scissions. For the degradation of poly lactic acid by random scission, it was found that M n must reduce to <5000 g/mol in order for a polymer to exhibit significant mass loss due to the diffusion of water-soluble short chains. In contrast, end scission was able to produce a significant fraction of water-soluble chains with little or no effect on M n . The production rate of water-soluble chains was linearly related to end scission but increase in an accelerated manner due to random scission. Molecular weight distributions were fitted to experimental data for the degradation of poly D-lactic acid.

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“…Among them, the polymer blends between biopolymers and synthetic polymers are of particular significance as they could be used as biomedical and biodegradable materials [3][4][5] . Based on the outstanding biodegradability, biocompatibility, and nontoxicity, poly(lactic acid-coglycolic acid) (PLGA) has received much attention for its potential applications [6][7][8][9][10][11][12] . Because of its unique structure and properties, poly(lactic acid-co-glycolic acid) has been widely used in the biomedical fields such as absorbable sutures, reconstructive implants, wound healing materials, temporal scaffolds for tissue engineering, and drug release systems [13][14][15][16][17][18][19][20][21][22][23] , etc.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical Properties of Poly(lactic acid-co-glycolic acid) Film Modified via Blending with Poly(butyl acrylate-co-methyl methacrylate)

Zhu¹,

Wang²,

Gao³

et al. 2013

Polímeros

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A series of poly(lactic acid-co-glycolic acid) (PLGA)/poly(butyl acrylate-co-methyl methacrylate) (P(BAco-MMA)) blend films with different P(BA-co-MMA) mole contents were prepared by casting the polymer blend solution in chloroform. Surface morphologies of the PLGA/P(BA-co-MMA) blend films were studied by scanning electron microscopy (SEM). Thermal, mechanical, and chemical properties of PLGA/P(BA-co-MMA) blend films were investigated by differential scanning calorimeter (DSC), thermogravimetric analysis (TGA), tensile tests, and surface contact angle tests. The introduction of P(BA-co-MMA) could modify the properties of PLGA films.

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Degradation mechanism of poly(lactic-co-glycolic) acid block copolymer cast films in phosphate buffer solution

Cited by 87 publications

References 40 publications

Modelling the degradation and elastic properties of poly(lactic-co-glycolic acid) films and regular open-cell tissue engineering scaffolds

Modelling the degradation and elastic properties of poly(lactic-co-glycolic acid) films and regular open-cell tissue engineering scaffolds

Computer Simulation of Polymer Chain Scission in Biodegradable Polymers

Physicochemical Properties of Poly(lactic acid-co-glycolic acid) Film Modified via Blending with Poly(butyl acrylate-co-methyl methacrylate)

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