Degradation Mechanism Induced by Psoriasis in Human Fingernails: A Different Approach

Coroabă, Adina; Pinteala, Tudor; Chiriac, Anca; Simionescu, Bogdan C.; Pinteală, Mariana

doi:10.1038/jid.2015.387

Cited by 13 publications

(6 citation statements)

References 11 publications

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“…In onychomycotic nails, a weakening of the disulfide bond structure occurs due to higher amounts of energetically less stable conformations of the S–S bonds . Psoriatic nails have also an increased porosity and lower amounts of disulfide bonds. , Although the degradation of the disulfide bonds leads to the loss of stability of the nail matrix, contributing to the morphology changes of keratin and making it less compact and less uniform, it remains unclear whether these changes can affect the results of trace element analyses. Further research is needed to establish whether the presence of inflammatory diseases or fungal infections should be part of the participation exclusion criteria in studies using toenail As to measure (environmental) As exposure.…”

Section: Resultsmentioning

confidence: 99%

Trace Element Distribution and Arsenic Speciation in Toenails as Affected by External Contamination and Evaluation of a Cleaning Protocol

Faidutti,

Doolette,

Hair

et al. 2024

Anal. Chem.

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Trace element concentrations in toenail clippings have increasingly been used to measure trace element exposure in epidemeological research. Conventional methods such as inductively coupled plasma mass spectrometry (ICP-MS) and high-performance liquid chromatography ICP-MS (HPLC-ICP-MS) are commonly used to measure trace elements and their speciation in toenails. However, the impact of the removal of external contamination on trace element quantification has not been thoroughly studied. In this work, the microdistribution of trace elements (As, Ca, Co, Cu, Fe, K, Mn, Ni, Rb, S, Sr, Ti, and Zn) in dirty and washed toenails and the speciation of As in situ in toenails were investigated using synchrotron X-ray fluorescence microscopy (XFM) and laterally resolved X-ray absorption near edge spectroscopy (XANES). XFM showed different distribution patterns for each trace element, consistent with their binding properties and nail structure. External (terrestrial) contamination was identified and distinguished from the endogenous accumulation of trace elements in toenails�contaminated areas were characterized by the co-occurrence of Co, Fe, and Mn with elements such as Ti and Rb (i.e., indicators of terrestrial contamination). The XANES spectra showed the presence of one As species in washed toenails, corresponding to As bound to sulfhydryl groups. In dirty specimens, a mixed speciation was found in localized areas, containing As III −S species and As V species. Arsenic V is thought to be associated with surface contamination and exogenous As. These findings provide new insights into the speciation of arsenic in toenails, the microdistribution of trace elements, and the effectiveness of a cleaning protocol in removing external contamination.

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Section: Resultsmentioning

confidence: 99%

Trace Element Distribution and Arsenic Speciation in Toenails as Affected by External Contamination and Evaluation of a Cleaning Protocol

Faidutti,

Doolette,

Hair

et al. 2024

Anal. Chem.

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“…FTIR spectra of nails represent a mine of information. The collection of this kind of information might be employed for providing a posteriori diagnostic analysis in other applications such as the diagnosis of psoriasis and diabetes mellitus . In psoriatic nails, specific molecular changes due to degradation mechanisms were observed in the secondary structure of keratin by studying the amide I region.…”

Section: Discussionmentioning

confidence: 99%

“…In psoriatic nails, specific molecular changes due to degradation mechanisms were observed in the secondary structure of keratin by studying the amide I region. In addition, absorption bands at 1170 and 1040 cm −1 , which were assigned to S–O bonds of the cysteic acid unit, were reported . The different biochemical fingerprints of psoriatic and onychomycotic nails could be used a differential diagnostic tool.…”

Section: Discussionmentioning

confidence: 99%

“…Biomedical applications of FTIR spectroscopy involve the identification and typing of several microorganisms such as Candida and Trichophyton species. Furthermore, infrared analysis of nails has been studied as an indicator of health by several research groups . The present study explores the possibilities of ATR‐FTIR spectroscopy in the detection and differentiation of causative agents of onychomycosis by analysing the spectral properties of (i) causative microorganisms plated out on Sabouraud dextrose agars (SDAs), (ii) nails infected with several causative agents in an ex vivo model and (iii) nails obtained from clinical routine.…”

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confidence: 99%

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Infrared spectroscopy as a novel tool to diagnose onychomycosis

Bruyne

Speeckaert²,

Boelens

et al. 2018

Br J Dermatol

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“…XPS can also provide information regarding metal oxidation states, chemical bonding, and general types of organic functional groups [15]. This technique can be used to identify the elemental concentration and characterize the molecular structure of various solid samples [1,3,12]. XPS wide scans for the inner surfaces of 3 latex powder free glovespalm samples Wide XPS scans allowed the qualitative and quantitative elemental characterization of the surfaces of the powder free latex gloves; the elements detected on the surfaces included C, N, O, Zn, Ca, S, Si, and Cd (Figures 2 and 3).…”

Section: Age Distribution Of the Respondersmentioning

confidence: 99%

A Follow-Up Study of the Occupational Hand Eczema and Skin Damage Risk in Healthcare Providers From Romania in Time of Covid-19

et al. 2020

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The aim of this work was to estimate the prevalence and risk factors of self-reported, work-related occupational hand eczema, targeting personnel working in hospitals and ambulatory units throughout Romania. A standardized questionnaire was specifically addressed to healthcare professionals from different medical fields. Out of 245 healthcare providers who took part in the survey, 161 (65.71%) were nurses, and 235 (95.92) women, which confirms that women are prevalent in this working sector. The latex powder-gloves were the most frequently implied trigger factor, 223 (91.02%) responders reported the daily use of protective gloves and 37 (15.12%) of them have reported the protective gloves as a possible cause for skin lesions. Also, an important part of responders testified a prolonged contact with water, which confirms the importance of wet environment in inducing occupational hand eczema. In addition, X-ray photoelectron spectroscopy (XPS) analysis of powder free latex gloves was performed in order to establish a correlation between the elemental composition and risk factors for hand eczema. The results support the implication of Cd and Ca, which were detected on the inner faces of the gloves, to the toxicity to the skin. RezumatObiectivul studiului a fost de a estima prevalența și factorii de risc asociați eczemelor de contact profesionale, raportate de personalul medical din spitalele și unitățile ambulatorii din România. Un chestionar standard a fost adresat personalului medical din diferite specialități. Din cele 245 de cadre medicale care au participat la studiu, 161 (65,71%) au fost infirmiere și 235 (95,92%) femei, ceea ce confirmă faptul că femeile sunt predominante în acest sector de activitate. Mănușile din latex pudrate au fost cel mai incriminat factor declanșator, 223 (91,02%) respondenți raportând folosirea zilnică a mănușilor, iar 37 (15,12%) dintre ei au raportat mănușile ca posibilă cauză a leziunilor cutanate. Totodată o pondere importantă a respondenților au raportat un contact prelungit cu apa, ceea ce confirmă importanța mediului umed în apariția eczemelor de contact profesionale. În plus, s-a efectuat analiza spectroscopică fotoelectronică cu raze X (XPS) a mănușilor din latex pentru a stabili o corelație între compozitia elementală și factorii de risc pentru eczema de contact. Rezultatele susțin implicarea Cd și Ca, care au fost detectate pe suprafața internă a mănușilor, în toxicitatea la nivel cutanat.

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Degradation Mechanism Induced by Psoriasis in Human Fingernails: A Different Approach

Cited by 13 publications

References 11 publications

Trace Element Distribution and Arsenic Speciation in Toenails as Affected by External Contamination and Evaluation of a Cleaning Protocol

Trace Element Distribution and Arsenic Speciation in Toenails as Affected by External Contamination and Evaluation of a Cleaning Protocol

Infrared spectroscopy as a novel tool to diagnose onychomycosis

A Follow-Up Study of the Occupational Hand Eczema and Skin Damage Risk in Healthcare Providers From Romania in Time of Covid-19

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