Abstract:BackgroundArtesunate is recommended by the world health organization (WHO) for parenteral treatment of severe Plasmodium falciparum malaria. However, artesunate is inherently unstable in an aqueous solution and hydrolyses rapidly after its preparation for injection. Therefore, the aim of the study was to evaluate the stabilizing effects of phosphate buffer and mannitol against short-term (ex-tempore) artesunate hydrolysis.MethodsA HPLC-UV isocratic method was developed using a reversed-phase fused core column … Show more
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