This study explored the crucial relationship between base fluids and polyamide, a prevalent polymer in electric vehicle (EV) components, with the aim of enhancing the longevity and performance of EVs in the context of thermal management by immersion cooling. Focusing on polyalphaolefin and polyol ester as base fluids, an immersion test was conducted to assess their interaction with polyamide 6 using adapted ASTM standards. The results revealed the significant influences of both fluids on the physical properties and chemical structure of polyamide. Polyol ester demonstrated a lesser impact on the chemical and mechanical properties of polyamide 6.