Degradation chemistry of a Vitamin D analogue (ecalcidene) investigated by HPLC–MS, HPLC–NMR and chemical derivatization

Zhang, Fa; Nunes, Mathews A.; Segmüller, Brigitte E.; Dunphy, Richard; Hesse, Robert H.; Setty, Sundara Katugam Srinivasetty

doi:10.1016/j.jpba.2005.07.052

Cited by 12 publications

(3 citation statements)

References 19 publications

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“…Table illustrates the retention percentages of vitamin D 3 in both concentrations of fortified canola oil during the three different heat treatments. Previous studies showed that vitamin D 3 degradation may occur due to the isomerization (Mahmoodani et al., ; Mahmoodani, Perera, Fedrizzi, Abernethy, & Chen, ; Temova & Roškar, ; Zhang et al., ). It seems that heat treatment converts vitamin D 3 into previtamin D 3 during a thermal isomerization conversion (Mahmoodani et al., ).…”

Section: Resultsmentioning

confidence: 99%

Thermal Stability and Kinetic Study on Thermal Degradation of Vitamin D₃ in Fortified Canola Oil

Zareie

Abbasi

Faghih

2019

Journal of Food Science

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Nowadays, fortified vegetable oils with vitamin D3 are widely available in different countries and are consumed daily. The reduction rate of added vitamin D3 in fortified canola oil during heating process, the changes in oxidative status, and the thermal kinetic degradation of vitamin D3 in the fortified oil were investigated. For this purpose, canola oil was fortified at two levels of vitamin D3 with 5.625 µg/mL (low concentration or LC) and 13.585 µg/mL (a high concentration or HC). Samples were heated isothermally at 100, 150, and 180 °C for 30 min. The vitamin D3 concentration was determined by the high‐performance liquid chromatographic method. The retention of vitamin D3 in samples treated at 100 °C for 30 min showed no significant reduction. Samples treated at 150 and 180 °C depending on the initial concentration showed the retention of 67.5% to 72.97% and 33.16% to 40.35% of vitamin D3, respectively. An inverse relationship was found between the increment of lipid oxidation products (peroxide and anisidine values) and the retention of vitamin D3. Kinetic parameters such as rate constant, activation energy, decimal reduction time, and quotient indicator were also calculated. An Arrhenius relationship was used for the assessment of temperature dependence of vitamin D3 degradation. Activation energies for vitamin D3 in LC and HC between 100 and 180 °C were found to be 44.01 and 38.77 kJ/mol, respectively. Practical Application The oil can be fortified with vitamin D3 at low cost and offers a good bioavailability. A high‐temperature cooking method may not be appropriate for the fortified products containing high lipid content.

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Section: Resultsmentioning

confidence: 99%

Thermal Stability and Kinetic Study on Thermal Degradation of Vitamin D₃ in Fortified Canola Oil

Zareie

Abbasi

Faghih

2019

Journal of Food Science

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“…[85] Based on investigations of the chemical properties of vitamin D analogs, it is plausible that pH influences the isomerization, storage, transport or metabolism of vitamin D3 in the dermis and epidermis in vivo . [86] It should also be noted that there are other pigmentation-related genes that have also been observed to influence the pH of the melanosome. [87] Thus, if there is some connection between skin pigmentation, pH, and vitamin D stability, it is possible that these events could be linked to polymorphic variants in other skin pigmentation genes.…”

Section: Discussionmentioning

confidence: 99%

Genetic ancestry, skin reflectance and pigmentation genotypes in association with serum vitamin D metabolite balance

Wilson

Roff

Dai

et al. 2011

Hormone Molecular Biology and Clinical Investigation

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Background Lower serum vitamin D (25(OH)D) among individuals with African ancestry is attributed primarily to skin pigmentation. However, the influence of genetic polymorphisms controlling for skin melanin content has not been investigated. Therefore, we investigated differences in non-summer serum vitamin D metabolites according to self-reported race, genetic ancestry, skin reflectance and key pigmentation genes (SLC45A2 and SLC24A5). Materials and Methods Healthy individuals reporting at least half African American or half European American heritage were frequency matched to one another on age (+/− 2 years) and sex. 176 autosomal ancestry informative markers were used to estimate genetic ancestry. Melanin index was measured by reflectance spectrometry. Serum vitamin D metabolites (25(OH)D3, 25(OH)D2 and 24,25(OH)2D3) were determined by high performance liquid chromatography (HPLC) tandem mass spectrometry. Percent 24,25(OH)2D3 was calculated as a percent of the parent metabolite (25(OH)D3). Stepwise and backward selection regression models were used to identify leading covariates. Results Fifty African Americans and 50 European Americans participated in the study. Compared with SLC24A5 111Thr homozygotes, individuals with the SLC24A5 111Thr/Ala and 111Ala/Ala genotypes had respectively lower levels of 25(OH)D3 (23.0 and 23.8 nmol/L lower, p-dominant=0.007), and percent 24,25(OH)2D3 (4.1 and 5.2 percent lower, p-dominant=0.003), controlling for tanning bed use, vitamin D/fish oil supplement intake, race/ethnicity, and genetic ancestry. Results were similar with melanin index adjustment, and were not confounded by glucocorticoid, oral contraceptive, or statin use. Conclusions The SLC24A5 111Ala allele was associated with lower serum vitamin 25(OH)D3 and lower percent 24,25(OH)2D3, independently from melanin index and West African genetic ancestry.

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“…Laboratory data including levels of intact parathyroid hormone (iPTH), serum albumin, high sensitive C-reactive protein (hsCRP) and serum calcium were gathered from medical records. Serum VD (VD2+ VD3) levels were analyzed using liquid chromatography–mass spectrometry (LC-MS, or the gold standard high-performance liquid chromatography [HPLC]-MS [27,28]) at the Kingmed Diagnostics Laboratory, Guangzhou, China.…”

Section: Methodsmentioning

confidence: 99%

Vitamin D status in chronic dialysis patients with depression: a prospective study

Zhang

et al. 2014

BMC Psychiatry

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BackgroundDepression is the most widely acknowledged psychological problem among end-stage renal disease (ESRD) patients. Depression may be associated with VD deficiency. The aims of this study are to (a) elucidate the prospective association between HsCRP, VD contents and depressive symptoms in the dialyzed population, and (b) find the effect of calcitriol supplementation on depression in dialyzed patients.MethodsIn this prospective study, 484 dialysis patients (382 hemodialysis [HD] cases and 102 peritoneal dialysis [PD] cases; aged 18–60 years) from two hospitals in southeast China were included. The depression in these patients was evaluated using the Chinese version of Beck’s Depression Inventory (BDI). All subjects answered the BDI-I questionnaire for assessment of depression levels in summer. A cut-off value of 16 was set to include dialysis patients with depression. All patients were divided into two groups depending on the absence (Group1) or presence (Group 2) of depression. The two groups took 0.5 μg/day 1,25-Dihydroxyvitamin D orally for one year. BDI Scores were recalculated for all patients. Sociodemographic, clinical data, and serum VD contents were also collected.ResultsA total of 484 participants (247 men [51.0%] and 237 women [49.0%]) were surveyed. Depressive symptoms were found in 213 (44.0%) patients. The baseline serum VD level (VD2 + VD3) was 17.6 ± 7.7 nmol/L. Patients with depressive symptoms have significantly higher serum HsCRP level and significantly lower serum VD level compared with the control group. After one-year follow-up, the supplementation of 0.5 μg/day calcitriol slightly improved the microinflammatory state such as lowering mean serum HsCRP level and improving serum VD level, but not in significantly enhancing the depressive symptoms.ConclusionsCalcitriol supplementation did not significantly enhance the depressive symptoms in our dialyzed population although patients with low levels of serum VD were more depressed. Therefore, more prospective randomized controlled trials are necessary to reveal the exact cause-and-effect relationship between VD status and depressive symptoms or VD status related to some specific subtypes in dialyzed patients.

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Degradation chemistry of a Vitamin D analogue (ecalcidene) investigated by HPLC–MS, HPLC–NMR and chemical derivatization

Cited by 12 publications

References 19 publications

Thermal Stability and Kinetic Study on Thermal Degradation of Vitamin D₃ in Fortified Canola Oil

Thermal Stability and Kinetic Study on Thermal Degradation of Vitamin D₃ in Fortified Canola Oil

Genetic ancestry, skin reflectance and pigmentation genotypes in association with serum vitamin D metabolite balance

Vitamin D status in chronic dialysis patients with depression: a prospective study

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Degradation chemistry of a Vitamin D analogue (ecalcidene) investigated by HPLC–MS, HPLC–NMR and chemical derivatization

Cited by 12 publications

References 19 publications

Thermal Stability and Kinetic Study on Thermal Degradation of Vitamin D3 in Fortified Canola Oil

Thermal Stability and Kinetic Study on Thermal Degradation of Vitamin D3 in Fortified Canola Oil

Genetic ancestry, skin reflectance and pigmentation genotypes in association with serum vitamin D metabolite balance

Vitamin D status in chronic dialysis patients with depression: a prospective study

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Thermal Stability and Kinetic Study on Thermal Degradation of Vitamin D₃ in Fortified Canola Oil

Thermal Stability and Kinetic Study on Thermal Degradation of Vitamin D₃ in Fortified Canola Oil