Degradation behaviour of self-reinforced 80L/20G PLGA devices in vitro

Välimaa, Tero; Laaksovirta, Susanna

doi:10.1016/j.biomaterials.2003.08.072

Cited by 27 publications

(19 citation statements)

References 27 publications

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“…

[3] , sistemas para liberação controlada de drogas [4] , stents [5] e dispositivos ortopédicos [6] . Atualmente fazem parte do cotidiano dos centros cirúrgicos no mundo inteiro.

Embora muitos dispositivos protéticos artificiais estejam disponíveis, poucos podem substituir completamente todas as complexas funções biológicas.

…”

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Polímeros bioreabsorvíveis na engenharia de tecidos

Barbanti

Zavaglia

Duek³

2005

Polímeros

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[3] , sistemas para liberação controlada de drogas [4] , stents [5] e dispositivos ortopédicos [6] . Atualmente fazem parte do cotidiano dos centros cirúrgicos no mundo inteiro.Embora muitos dispositivos protéticos artificiais estejam disponíveis, poucos podem substituir completamente todas as complexas funções biológicas. Em situações clíni-cas mais severas somente o transplante do órgão retoma as atividades orgânicas. Assim, de uma forma idealizada, a melhor alternativa seria obter um novo órgão ou tecido, substituindo aquele que não desempenha normalmente suas funções. Nos dias de hoje, a idéia da reconstrução de órgãos e tecidos criados em laboratório é amplamente difundida e investigada no mundo todo [7,8] . Resumo: A Engenharia de Tecidos consiste em um conjunto de conhecimentos e técnicas para a reconstrução de novos órgãos e tecidos. Baseada em conhecimentos das áreas de ciência e engenharia de materiais, biológica e médica, a técnica envolve a expansão in vitro de células viáveis do paciente doador sobre suportes de polímeros bioreabsorvíveis. O suporte degrada enquanto um novo órgão ou tecido é formado. Os poli(α-hidróxi ácidos) representam a principal classe de polímeros sintéticos bioreabsorvíveis e biodegradáveis utilizados na engenharia de tecidos. No desenvolvimento e na seleção desses materiais, o tempo de degradação é fundamental para o sucesso do implante. Os estudos e os desafios atuais são normalmente direcionados ao entendimento das relações entre composição química, cristalinidade, morfologia do suporte, e o processamento desses materiais. Este artigo faz uma revisão dos trabalhos recentes sobre a utilização dos polímeros sintéticos bioreabsorvíveis como suportes na engenharia de tecidos. Engenharia de tecidos Palavras-chave: Engenharia de tecidos, polímeros bioreabsorvíveis, poli(α-hidróxi ácidos). Bioresorbable Polymers in Tissue EngineeringAbstract: Tissue Engineering is based on a group of techniques for the reconstruction of new organs and tissues. Based on knowledge of materials science and engineering, biology and medicine, the technique involves the in vitro expansion of viable cells obtained from the patient on the polymeric scaffolds. The scaffold degrades while a new organ or tissue is formed. The poly(α-hydroxy acids) are the principal biodegradable and bioresorbable polymers used in tissue engineering. In developing and selecting bioresorbable scaffolds, the degradation time is fundamental for successful biocompatibility and biofuncionality. Hence, degradation studies often address variables such as the chemical composition, crystallinity, morphology of the scaffold and the processing of these materials. This paper reviews recent work in bioresorbable polymers used as scaffolds in the tissue engineering. Keywords: Tissue engineering, bioresorbable polymers, poly(α-hydroxy acids). IntroduçãoQuando a estrutura biológica de um órgão ou tecido não pode ser reparada, a alternativa viável para o restabelecimento das funções normais do paciente é repô-la com um implante feito de um b...

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“…

[3] , sistemas para liberação controlada de drogas [4] , stents [5] e dispositivos ortopédicos [6] . Atualmente fazem parte do cotidiano dos centros cirúrgicos no mundo inteiro.

Embora muitos dispositivos protéticos artificiais estejam disponíveis, poucos podem substituir completamente todas as complexas funções biológicas.

…”

unclassified

“…, sistemas para liberação controlada de drogas [4] , stents [5] e dispositivos ortopédicos [6] . Atualmente fazem parte do cotidiano dos centros cirúrgicos no mundo inteiro.…”

unclassified

Polímeros bioreabsorvíveis na engenharia de tecidos

Barbanti

Zavaglia

Duek³

2005

Polímeros

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“…Typical in vitro degradation models for absorbable polymers and absorbable medical devices incorporate hydrolysis but fewer models include compounding effects from the local environment. As demonstrated previously, temperature, [3][4][5] media composition, [6][7][8] local pH, 9,10 and the presence of mechanical loading 6,[11][12][13][14] have been shown to affect polymer properties during degradation in vitro. In particular, the presence of mechanical loading in vivo has been hypothesized to be a significant contributor to differences observed between in vitro and in vivo degradation.…”

Section: Introductionmentioning

confidence: 93%

Creep loading during degradation attenuates mechanical property loss in PLGA

Dreher

Nagaraja

2014

J Biomed Mater Res

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While absorbable materials and medical devices primarily degrade through hydrolysis, their degradation kinetics are sensitive to environmental conditions, including temperature, pH, and mechanical loading. While there is some consistent information in the literature suggesting that strain controlled loading accelerates strength loss, there is much more limited information on the interaction between degradation and mechanical load applied under force control. Force control conditions impose a different stress state on the material and therefore, may exhibit different effects on degradation. In this study, the interaction between loading and degradation rate for an exemplary absorbable polymer, poly(l‐lactide‐co‐glycolide), was investigated. The results indicated that load during degradation results in significant polymer creep, which is associated with increased force loss, but decreased strength loss (i.e., stress based parameters such as ultimate stress). This study further identified that changes to the degradation kinetics from exposure to loading were not associated with alterations to polymer crystallinity but were associated with delayed loss of molecular weight. Overall, these results demonstrate the importance of investigating the interaction between loading and degradation and that physical changes, such as those induced by creep, rather than chemical changes offer the strongest explanation for alteration of degradation kinetics. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 700–708, 2015.

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“…3 Synthetic HA has been extensively studied and used as it presents biocompatibility with bone minerals and does not present distinct phases of other calcium phosphates (Ca-P) when carefully synthesized. 7,8 However, implants made with pure HA exhibit low tensile strength, impact and fatigue resistance. 10,11 Recent research focuses on overcoming limitations of calcium phosphates and HA ceramics such as low bioresorbability, low surface area and low bioreactivity, and the improvement of their biological properties.…”

Section: Introductionmentioning

confidence: 99%

“…6 Synthetic HA nanoparticles exhibit good biocompatibility, bioactivity and osteoinducibility. [1][2][3][6][7][8] Due to its unique quantum confining effects and the reactivity of the surface area, nanocrystalline HA exhibits better bioactivity, biocompatibility and improved mechanical properties than microcrystalline and bulk HA. 9 HA is the major mineral component of bone and teeth structures, corresponding to about 30-70% of the mass of bones and teeth.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Optimization of Colloidal Hydroxyapatite Nanoparticles by Hydrothermal Processes

Arantes¹,

Coimbra²,

Cristovan³

et al. 2018

J. Braz. Chem. Soc.

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This paper reports an optimized, simple, fast and inexpensive method for hydroxyapatite (HA) nanoparticle synthesis. Through a multivariate statistical analysis using a factorial design with 2 3 resolution, an empirical model was developed which allows control of the shape and size of the HA nanoparticles. This model was used to synthesize HA nanoparticles with sizes between 8 and 600 nm, formed by oriented attachment growth mechanism. The structure was confirmed by transmission electron microscopy (TEM) and scanning electron microscopy (SEM) images, which also showed that HA nanoparticles had well-defined nanorod forms and narrow size distributions. It was observed that the model is statistically significant and the main parameter for the growth of crystals in the hydrothermal process was temperature.

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Degradation behaviour of self-reinforced 80L/20G PLGA devices in vitro

Cited by 27 publications

References 27 publications

Polímeros bioreabsorvíveis na engenharia de tecidos

Polímeros bioreabsorvíveis na engenharia de tecidos

Creep loading during degradation attenuates mechanical property loss in PLGA

Synthesis and Optimization of Colloidal Hydroxyapatite Nanoparticles by Hydrothermal Processes

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