Degradation behaviour of AZ80E magnesium alloy exposed to phosphate buffer saline medium

Heakal, F. El-Taib; Shehata, O.S.; Tantawy, N.S.

doi:10.1016/j.corsci.2014.06.008

Cited by 35 publications

(10 citation statements)

References 56 publications

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“…In contrast, the HP Mg discs in Group 0 suffered severe corrosion and were almost depleted. Due to the great potential difference, which is −1.6 V vs SCE for pure Mg 23 and −0.4 V vs SCE for Ti in PBS 24 , galvanic corrosion occurred and significantly accelerated the corrosion of Mg. The SEM results demonstrated that there was a large area that had non-uniform degradation ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Accelerating Corrosion of Pure Magnesium Co-implanted with Titanium in Vivo

Hou

Han

Zhao

et al. 2017

Sci Rep

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Magnesium is a type of reactive metal, and is susceptible to galvanic corrosion. In the present study, the impact of coexistence of Ti on the corrosion behavior of high purity Mg (HP Mg) was investigated both in vitro and in vivo. Increased corrosion rate of HP Mg was demonstrated when Mg and Ti discs were not in contact. The in vivo experiments further confirmed accelerating corrosion of HP Mg screws when they were co-implanted with Ti screws into Sprague-Dawley rats’ femur, spacing 5 and 10 mm. Micro CT scan and 3D reconstruction revealed severe corrosion morphology of HP Mg screws. The calculated volume loss was much higher for the HP Mg screw co-implanted with Ti screw as compared to that co-implanted with another Mg screw. Consequently, less new bone tissue ingrowth and lower pullout force were found in the former group. It is hypothesized that the abundant blood vessels on the periosteum act as wires to connect the Mg and Ti screws and form a galvanic-like cell, accelerating the corrosion of Mg. Therefore, a certain distance is critical to maintain the mechanical and biological property of Mg when it is co-implanted with Ti.

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Section: Resultsmentioning

confidence: 99%

Accelerating Corrosion of Pure Magnesium Co-implanted with Titanium in Vivo

Hou

Han

Zhao

et al. 2017

Sci Rep

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“…Initial testing used immersion conditions in simple NaCl solutions, but these were found to be inappropriate [42]. Subsequently, a wide range of solutions and methodologies have been explored [36,[43][44][45][46], each with advantages and limitations, although some studies still continue to use NaCl solutions [47]. Table 1 provides a comparison of the constituent elements of several commonly used in vitro immersion solution [24,[48][49][50].…”

Section: Variability Of In Vitro Testing and The Need For Standardisamentioning

confidence: 99%

Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

2017

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The factors that influence magnesium (Mg) corrosion in vitro are systematically evaluated from a review of the relevant literature. We analysed the influence of the following factors on Mg biocorrosion in vitro: (i) inorganic ions, including both anions and cations, (ii) organic components such as proteins, amino acids and vitamins, and (iii) experimental parameters such as temperature, pH, buffer system and flow rate. Considerations and recommendations towards a standardised approach to in vitro biocorrosion testing are given. Several potential simulated body fluids are recommended. Implementing a standardised approach to experimental parameters has the potential to significantly reduce variability between in vitro biocorrosion tests, and to help build towards a methodology that accurately and consistently mimics in vivo corrosion. However, there are also knowledge gaps with regard to how best to characterise the in vivo environment and corrosion mechanism. The assumption that blood plasma is the correct bodily fluid upon which to base in vitro methodologies is examined, and factors that influence the corrosion mechanism in vivo, such as specimen encapsulation, bear consideration for further studies.

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“…The W element is serially connected with the charge transfer resistance ( R ct ) and the two are in parallel with a constant phase element (CPE) that replaces the ideal double‐layer capacitance ( C dl ). The frequency‐independent admittance ( Q ) of the CPE has an empirical exponent (0≤ α ≤1) utilized to express its deviation from the ideal behavior due to surface heterogeneity [39, 40] and related to its impedance value ( Z CPE ) by the expression: Z CPE =1/ Q

{{\left(j\omega \right)}^{\alpha }}

, where

{\omega =2\pi f}

is the angular frequency (in rad s −1 ), f is the ac signal frequency (in s −1 ) and

{j=-{1}^{{ 1/2 }}}

is the imaginary number. At

{\omega }

=1, 1/ C dl will be equal to 1/ Q [40].…”

Section: Resultsmentioning

confidence: 99%

Potential Application of Carbon‐based Electrical Sensor for the Highly Sensitive Diltiazem HCl Quantification in its Pharmaceutical Products and Biological Samples

Mohamed

Heakal

2022

Electroanalysis

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Diltiazem (DTZ) hydrochloride, a calcium channel blocker compound, is a very well‐known drug used by many clinicians to treat important diseases playing a role in increased morbidity and mortality among adults worldwide, namely hypertension, cardiac arrhythmia, and ischemic heart disease (angina pectoris). These diseases are a common public health concern, implying that the construction of a specific, accurate, and simple sensor for DTZ determination is needed. Herein, an innovative, portable, and sensitive modified carbon paste electrode (MCPE) was seamlessly developed based on the affordable green compound N‐bromosuccinimide (NBS) as a sensing material and tricresyl phosphate as a solvent mediator for the voltammetric determination of DTZ. The proposed NBS‐MCPE exhibited an excellent electrocatalytic activity towards the oxidation of DTZ molecules in a phosphate buffer solution of pH 5.0 in presence of 20 μM sodium dodecyl sulfate to improve the developed sensor performance. The sensor was found to respond linearly to the DTZ drug over a wide concentration ranging from 1 μM to 300 μM with a low limit of detection. LSV and EIS measurements were also used to scrutinize our sensor, in addition to using scanning electron microscopy and energy dispersive X‐ray analysis techniques for its surface morphology inspection before and after soaking in the drug‐containing solution. The applicability of the proposed sensor for the rapid, sensitive, and selective determination of DTZ in pharmaceutical preparation and human urine samples was assessed and the obtained results were compared with that of the reported HPLC analytical method.

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Degradation behaviour of AZ80E magnesium alloy exposed to phosphate buffer saline medium

Cited by 35 publications

References 56 publications

Accelerating Corrosion of Pure Magnesium Co-implanted with Titanium in Vivo

Accelerating Corrosion of Pure Magnesium Co-implanted with Titanium in Vivo

Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

Potential Application of Carbon‐based Electrical Sensor for the Highly Sensitive Diltiazem HCl Quantification in its Pharmaceutical Products and Biological Samples

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