Degradation behaviour and mechanical properties of magnesium implants in rabbit tibiae

Krause, A.; Höh, N. von der; Bormann, Dirk; Krause, Christian; Bach, Friedrich-Willhelm; Windhagen, Henning; Meyer‐Lindenberg, Andrea

doi:10.1007/s10853-009-3936-3

Cited by 193 publications

(203 citation statements)

References 22 publications

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“…6b). In 16 contrast, Mg2Ag implants led to a callus that was significantly larger compared to the control group as early as day 7 and at all subsequent points of analysis. Furthermore, the size of the callus did not decrease 14 days after fracture, demonstrating an augmented callus formation due to intramedullary Mg2Ag implants (Fig.…”

Section: Analysis Of Callus Formation Cartilage Turnover and Mineralmentioning

confidence: 73%

“…Among the various biodegradable materials, magnesium (Mg) and Mgcontaining alloys have a long history in the musculoskeletal field [7]. Based on their high biocompatibility, biodegradability, and similar mechanical properties to bone, many studies investigated the use of Mg and its alloys for applications in orthopedic surgery [8][9][10][11][12][13][14][15][16][17]. In addition to its favorable mechanical properties, Mg has been shown to increase osteoblast differentiation in vitro [18,19] and to induce new bone formation in vivo [13], demonstrating a high osteogenic potential.…”

Section: Introductionmentioning

confidence: 99%

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Intramedullary Mg2Ag nails augment callus formation during fracture healing in mice

Jähn¹,

Saito

Taipaleenmäki

et al. 2016

Acta Biomaterialia

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Intramedullary stabilization is frequently used to treat long bone fractures. Implants usually remain unless complications arise. Since implant removal can become technically very challenging with the potential to cause further tissue damage, biodegradable materials are emerging as alternative options. Magnesium (Mg)-based biodegradable implants have a controllable degradation rate and good tissue compatibility, which makes them attractive for musculoskeletal research. Here we report for the first time the implantation of intramedullary nails made of an Mg alloy containing 2% silver (Mg2Ag) into intact and fractured femora of mice. Prior in vitro analyses revealed an inhibitory effect of Mg2Ag degradation products on osteoclast differentiation and function with no impair of osteoblast function. In vivo, Mg2Ag implants degraded under non-fracture and fracture conditions within 210 days and 133 days, respectively. During fracture repair, osteoblast function and subsequent bone formation were enhanced, while osteoclast activity and bone resorption were decreased, leading to an augmented callus formation. We observed a widening of the femoral shaft under steady state and regenerating conditions, which was at least in part due to an uncoupled bone remodeling. However, Mg2Ag implants did not cause any systemic adverse effects. These data suggest that Mg2Ag implants might be promising for intramedullary fixation of long bone fractures, a novel concept that has to be further investigated in future studies.

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Section: Analysis Of Callus Formation Cartilage Turnover and Mineralmentioning

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Intramedullary Mg2Ag nails augment callus formation during fracture healing in mice

Jähn¹,

Saito

Taipaleenmäki

et al. 2016

Acta Biomaterialia

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“…Krausse et al [76] investigated the biodegradation behavior of LAE442 alloys and reported that the alloys have sufficient initial strength to be used in weight bearing applications in bones. In reference [77], the authors characterized Mg-1.21Li-1.12Ca-1Y alloy and reported that the alloy exhibited better tensile properties in extruded state due to the refinement of microstructure.…”

Section: Mg-li-re Higher Alloy Systemmentioning

confidence: 99%

Mechanical Properties of Magnesium-Rare Earth Alloy Systems: A Review

Tekumalla

Seetharaman

Almajid

2014

Metals

165

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Magnesium-rare earth based alloys are increasingly being investigated due to the formation of highly stable strengthening phases, activation of additional deformation modes and improvement in mechanical properties. Several investigations have been done to study the effect of rare earths when they are alloyed to pure magnesium and other Mg alloys. In this review, the mechanical properties of the previously investigated different magnesium-rare earth based binary alloys, ternary alloys and other higher alloys with more than three alloying elements are presented.

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“…[56,67,[70][71] They have shown that RE can be detected in the corrosion layers and that percentage increased with the implantation time. Krause et al, [56] found 58% M a n u s c r i p t increase of the RE content in the outer layer of the implant surfaces between the 3 rd and 6 th month after implantation. Recently, Dziuba et al, [70] reported long term in vivo degradation behavior of ZEK100.…”

Section: Discussionmentioning

confidence: 99%

“…RE/Mg relationships were selected based on Krause et al, [56] results about a RE-containing Mg alloy. were selected.…”

Section: Chemicalsmentioning

confidence: 99%

Cellular response to rare earth mixtures (La and Gd) as components of degradable Mg alloys for medical applications

Grillo

Álvarez

Mele

2014

Colloids and Surfaces B: Biointerfaces

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Degradation behaviour and mechanical properties of magnesium implants in rabbit tibiae

Cited by 193 publications

References 22 publications

Intramedullary Mg2Ag nails augment callus formation during fracture healing in mice

Intramedullary Mg2Ag nails augment callus formation during fracture healing in mice

Mechanical Properties of Magnesium-Rare Earth Alloy Systems: A Review

Cellular response to rare earth mixtures (La and Gd) as components of degradable Mg alloys for medical applications

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