2001
DOI: 10.1002/1097-4636(20010605)55:3<401::aid-jbm1029>3.0.co;2-h
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Degradation behaviors of biodegradable macroporous scaffolds prepared by gas foaming of effervescent salts

Abstract: Biodegradable polymeric scaffolds for tissue engineering were fabricated by a gas-foaming/salt-leaching method using a combination of two effervescent salts, ammonium bicarbonate and citric acid. Poly(D,L-lactic-co-glycolic acid) (PLGA) in a state of gel-like paste was first produced by precipitation of PLGA dissolved in chloroform into ethanol. The polymer slurry was mixed with sieved particles of ammonium bicarbonate, molded, and then immersed in an aqueous solution of citric acid to generate macroporous sca… Show more

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Cited by 234 publications
(152 citation statements)
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References 32 publications
(43 reference statements)
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“…Polymer degradation generally decreases the hydrophobicity [41], thus the faster degrading polymers would be less likely to aggregate. PLG with a molecular weight between 80 and 97 kDa, similar to the high MW PLG, had a 3% to 15% mass loss after 12 weeks [42,43]. However, polymers with low MW (8 kDa) exhibited a 78.5% decrease in molecular weight after only 14 days in vitro [44].…”
Section: Discussionmentioning
confidence: 95%
“…Polymer degradation generally decreases the hydrophobicity [41], thus the faster degrading polymers would be less likely to aggregate. PLG with a molecular weight between 80 and 97 kDa, similar to the high MW PLG, had a 3% to 15% mass loss after 12 weeks [42,43]. However, polymers with low MW (8 kDa) exhibited a 78.5% decrease in molecular weight after only 14 days in vitro [44].…”
Section: Discussionmentioning
confidence: 95%
“…It was carried out by dissolving a gas at elevated pressure (physical blowing agent) [11][12][13] or by incorporated a chemical that yields gaseous decomposition products (chemical blowing agent) [14][15][16]. The foaming technique generally leads to pore structures that are not as fully interconnected as the previously mentioned ones.…”
Section: Introductionmentioning
confidence: 99%
“…Then pressure is discharge to form thermodynamic instability of dissolved CO 2 that leads to nucleation and growth of gas vesicles, created pores within polymer matrix. Yoon J.J et al used this method to create high-porous PLGA sponges (Yoon & Park, 2001). Solid PLGA disks, prepared by compressing casting or solution casting, were saturated with CO 2 under high pressure, then pressure was discharged and formed macroporous structure.…”
Section: High Pressure Treatmentmentioning
confidence: 99%