Degradation behavior of hydrophilized PLGA scaffolds prepared by melt-molding particulate-leaching method: Comparison with control hydrophobic one

Oh, Se Heang; Kang, Soung Gon; Lee, Jin Ho

doi:10.1007/s10856-006-6816-2

Cited by 85 publications

(49 citation statements)

References 20 publications

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“…Furthermore, in a study comparing a PLGA/PVA scaffold with hydrophilic properties, to another PLGA scaffold with hydrophobic properties, cell adhesion and growth faired better on the PLGA/PVA scaffolds. 113 Other hydrophilic materials that present highly hydrated surfaces (ie, hydrogels, polyethylene oxide, pHEMA, PEO) create a substantial barrier to protein adsorption and inhibit cellular adhesion. 37 …”

Section: Implant-associated Factors That Influence Fbrmentioning

confidence: 99%

Short-Term and Long-Term Effects of Orthopedic Biodegradable Implants

Amini

Wallace

Nukavarapu

2011

J Long Term Eff Med Implants

138

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Presently, orthopedic and oral/maxillofacial implants represent a combined $2.8 billion market, a figure expected to experience significant and continued growth. Although traditional permanent implants have been proved clinically efficacious, they are also associated with several drawbacks, including secondary revision and removal surgeries. Non-permanent, biodegradable implants offer a promising alternative for patients, as they provide temporary support and degrade at a rate matching tissue formation, and thus, eliminate the need for secondary surgeries. These implants have been in clinical use for nearly 25 years, competing directly with, or maybe even exceeding, the performance of permanent implants. The initial implantation of biodegradable materials, as with permanent materials, mounts an acute host inflammatory response. Over time, the implant degradation profile and possible degradation product toxicity mediate long-term biodegradable implant-induced inflammation. However, unlike permanent implants, this inflammation is likely to cease once the material disappears. Implant-mediated inflammation is a critical determinant for implant success. Thus, for the development of a proactive biodegradable implant that has the ability to promote optimal bone regeneration and minimal detrimental inflammation, a thorough understanding of short- and long-term inflammatory events is required. Here, we discuss an array of biodegradable orthopedic implants, their associated short- and long- term inflammatory effects, and methods to mediate these inflammatory events.

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Section: Implant-associated Factors That Influence Fbrmentioning

confidence: 99%

Short-Term and Long-Term Effects of Orthopedic Biodegradable Implants

Amini

Wallace

Nukavarapu

2011

J Long Term Eff Med Implants

138

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“…PLGA scaffolds, for instance, degraded faster in vivo than in vitro , 408 and in addition to phagocytosis, enzymatic hydrolysis, the regions of low pH at the cell–material interface, and biomechanical stress, increased wetting in biological conditions can be another factor responsible for this effect. 409 This is especially relevant for hydrophobic polymers, the category to which unmodified PLGA belongs.…”

Section: Additional Challengesmentioning

confidence: 99%

Nanostructured Platforms for the Sustained and Local Delivery of Antibiotics in the Treatment of Osteomyelitis

Uskoković

2015

Crit Rev Ther Drug Carrier Syst

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This article provides a critical view of the current state of the development of nanoparticulate and other solid-state carriers for the local delivery of antibiotics in the treatment of osteomyelitis. Mentioned are the downsides of traditional means for treating bone infection, which involve systemic administration of antibiotics and surgical debridement, along with the rather imperfect local delivery options currently available in the clinic. Envisaged are more sophisticated carriers for the local and sustained delivery of antimicrobials, including bioresorbable polymeric, collagenous, liquid crystalline, and bioglass- and nanotube-based carriers, as well as those composed of calcium phosphate, the mineral component of bone and teeth. A special emphasis is placed on composite multifunctional antibiotic carriers of a nanoparticulate nature and on their ability to induce osteogenesis of hard tissues demineralized due to disease. An ideal carrier of this type would prevent the long-term, repetitive, and systemic administration of antibiotics and either minimize or completely eliminate the need for surgical debridement of necrotic tissue. Potential problems faced by even hypothetically “perfect” antibiotic delivery vehicles are mentioned too, including (i) intracellular bacterial colonies involved in recurrent, chronic osteomyelitis; (ii) the need for mechanical and release properties to be adjusted to the area of surgical placement; (iii) different environments in which in vitro and in vivo testings are carried out; (iv) unpredictable synergies between drug delivery system components; and (v) experimental sensitivity issues entailing the increasing subtlety of the design of nanoplatforms for the controlled delivery of therapeutics.

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“…A higher concentration of enzymes, free radicals, antibodies and other protein species adsorbed on the surface of the carriers could all significantly accelerate its degradation and increase the kinetic order of the release profiles. These factors, in addition to phagocytosis and increased wetting, are responsible for the fact that PLGA scaffolds, for instance, degrade faster in vivo than in vitro [91]. We know now that although size, shape, surface charge, chemistry and mechanical properties of nanoparticles influence their biodistribution profiles, the route of uptake and the mechanism of interaction with the cell are mainly determined by their protein corona [92], and similar effects are to be expected with respect to the cell and tissue response to any material in a biological milieu.…”

Section: Expert Opinionmentioning

confidence: 99%

Nanoparticulate drug delivery platforms for advancing bone infection therapies

Uskoković

Desai

2014

Expert Opinion on Drug Delivery

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Introduction The ongoing surge of resistance of bacterial pathogens to antibiotic therapies and the consistently aging median member of the human race signal an impending increase in the incidence of chronic bone infection. Nanotechnological platforms for local and sustained delivery of therapeutics hold the greatest potential for providing minimally invasive and maximally regenerative therapies for this rare but persistent condition. Areas covered Shortcomings of the clinically available treatment options, including poly(methyl methacrylate) beads and calcium sulfate cements, are discussed and their transcending using calcium-phosphate/polymeric nanoparticulate composites is foreseen. Bone is a composite wherein the weakness of each component alone is compensated for by the strength of its complement and an ideal bone substitute should be fundamentally the same. Expert opinion Discrepancy between in vitro and in vivo bioactivity assessments is highlighted, alongside the inherent imperfectness of the former. Challenges entailing the cross-disciplinary nature of engineering a new generation of drug delivery vehicles are delineated and it is concluded that the future for the nanoparticulate therapeutic carriers belongs to multifunctional, synergistic and theranostic composites capable of simultaneously targeting, monitoring and treating internal organismic disturbances in a smart, feedback fashion and in direct response to the demands of the local environment.

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Degradation behavior of hydrophilized PLGA scaffolds prepared by melt-molding particulate-leaching method: Comparison with control hydrophobic one

Cited by 85 publications

References 20 publications

Short-Term and Long-Term Effects of Orthopedic Biodegradable Implants

Short-Term and Long-Term Effects of Orthopedic Biodegradable Implants

Nanostructured Platforms for the Sustained and Local Delivery of Antibiotics in the Treatment of Osteomyelitis

Nanoparticulate drug delivery platforms for advancing bone infection therapies

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