Degradation behavior of biodegradable Fe35Mn alloy stents

Sing, N. B.; Mostavan, Afghany; Hamzah, Esah; Hermawan, Hendra

doi:10.1002/jbm.b.33242

Cited by 21 publications

(10 citation statements)

References 21 publications

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“…To enhance the material properties with respect to the requirements, the addition of different alloying elements such as Mn, Co, Al, W, Sn, B, C, and S was investigated [ 24 ]. Since Mn was found to show a sufficient biocompatibility and significantly enhance the mechanical properties, many studies focused on different compositions of FeMn alloys [ 15 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ]. Even the magnetic properties of FeMn alloys were found to be highly beneficial for the intended use.…”

Section: Introductionmentioning

confidence: 99%

Magnetron Sputtering as a Fabrication Method for a Biodegradable Fe32Mn Alloy

2017

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Biodegradable metals are a topic of great interest and Fe-based materials are prominent examples. The research task is to find a suitable compromise between mechanical, corrosion, and magnetic properties. For this purpose, investigations regarding alternative fabrication processes are important. In the present study, magnetron sputtering technology in combination with UV-lithography was used in order to fabricate freestanding, microstructured Fe32Mn films. To adjust the microstructure and crystalline phase composition with respect to the requirements, the foils were post-deposition annealed under a reducing atmosphere. The microstructure and crystalline phase composition were investigated by scanning electron microscopy, energy dispersive X-ray spectroscopy, and X-ray diffraction. Furthermore, for mechanical characterization, uniaxial tensile tests were performed. The in vitro corrosion rates were determined by electrochemical polarization measurements in pseudo-physiological solution. Additionally, the magnetic properties were measured via vibrating sample magnetometry. The foils showed a fine-grained structure and a tensile strength of 712 MPa, which is approximately a factor of two higher compared to the sputtered pure Fe reference material. The yield strength was observed to be even higher than values reported in literature for alloys with similar composition. Against expectations, the corrosion rates were found to be lower in comparison to pure Fe. Since the annealed foils exist in the austenitic, and antiferromagnetic γ-phase, an additional advantage of the FeMn foils is the low magnetic saturation polarization of 0.003 T, compared to Fe with 1.978 T. This value is even lower compared to the SS 316L steel acting as a gold standard for implants, and thus enhances the MRI compatibility of the material. The study demonstrates that magnetron sputtering in combination with UV-lithography is a new concept for the fabrication of already in situ geometrically structured FeMn-based foils with promising mechanical and magnetic properties.

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Section: Introductionmentioning

confidence: 99%

Magnetron Sputtering as a Fabrication Method for a Biodegradable Fe32Mn Alloy

2017

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“…Controlled corrosion rate is crucial to BMS as it influences the loss of mechanical integrity and release of corroded products during in vivo biodegradation, accordingly affects the biocompatibility or tolerance limit of these products by the surrounding tissues. 14 Moreover, fine-grained metals have been found to exhibit better host-implant interactions and lessen the inflammatory response. 15 …”

Section: Introductionmentioning

confidence: 99%

Effect of grain sizes on mechanical properties and biodegradation behavior of pure iron for cardiovascular stent application

et al. 2014

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Pure iron has been demonstrated as a potential candidate for biodegradable metal stents due to its appropriate biocompatibility, suitable mechanical properties and uniform biodegradation behavior. The competing parameters that control the safety and the performance of BMS include proper strength-ductility combination, biocompatibility along with matching rate of corrosion with healing rate of arteries. Being a micrometre-scale biomedical device, the mentioned variables have been found to be governed by the average grain size of the bulk material. Thermo-mechanical processing techniques of the cold rolling and annealing were used to grain-refine the pure iron. Pure Fe samples were unidirectionally cold rolled and then isochronally annealed at different temperatures with the intention of inducing different ranges of grain size. The effect of thermo-mechanical treatment on mechanical properties and corrosion rates of the samples were investigated, correspondingly. Mechanical properties of pure Fe samples improved significantly with decrease in grain size while the corrosion rate decreased marginally with decrease in the average grain sizes. These findings could lead to the optimization of the properties to attain an adequate biodegradation-strength-ductility balance.

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“…The correct integration of these elements is one of the issues of the present study of electroforming processes, as they need an extensive experimental assessment in order to achieve optimized systems. The development of electroformed iron enriches the choice of biodegradable metals available for cardiovascular stent [32] and expectedly useful for other applications such as bone implants [33,34].…”

Section: Resultsmentioning

confidence: 99%

Electroforming as a New Method for Fabricating Degradable Pure Iron Stent

Purnama

Mostavan

Paternoster

2015

Springer Series in Biomaterials Science and Engineering

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The first example of a documented electroforming process dates back to 1837 when a layer of electrodeposited copper was found on the surface of a printing plate. Since then, it became a basic manufacturing process to produce delicate metallic components such as nickel thin foils for solar panels, perforated screenprinting cylinders used for fabric and carpet printings, digital recording devices, etc. Recently, electroforming is used for the fabrication of iron-based materials designed for cardiovascular stents. Electroformed iron shows a higher corrosion rate in simulated biological environment; this behaviour is supposed to be influenced by its microstructure which is finer than that of iron produced with traditional techniques. A high corrosion rate can be beneficial for cardiovascular stent applications: a complete stent dissolution in 12-18 months can effectively prevent both late thrombosis and further treatment of paediatric patients, usually requiring a continuous vessel remodelling. Faster corrosion rate of iron-based material is advantageous for cardiovascular stent application in order to avoid late stent thrombosis and arterial growth mismatch in young patients leading to a secondary revascularization procedure. Electroformed iron has mechanical properties comparable to those of stainless steel (stent reference metal) with the advantage of the total dissolution of the material after the accomplishment of its function: for this reason, this metal can be considered as a valid alternative to magnesium-based materials. Nevertheless, electroforming is influenced by parameters such as electrolyte bath composition, current density, pH, temperature, additives, cathode, etc. that have a significant effect on the structure of the produced materials.

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Degradation behavior of biodegradable Fe35Mn alloy stents

Cited by 21 publications

References 21 publications

Magnetron Sputtering as a Fabrication Method for a Biodegradable Fe32Mn Alloy

Magnetron Sputtering as a Fabrication Method for a Biodegradable Fe32Mn Alloy

Effect of grain sizes on mechanical properties and biodegradation behavior of pure iron for cardiovascular stent application

Electroforming as a New Method for Fabricating Degradable Pure Iron Stent

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