Degradable tannic acid/polyethyleneimine polyplex particles with highly antioxidant and antimicrobial effects

Şahiner, Nurettin; Sagbas, Selin; Şahiner, Mehtap; Demirci, Şahin

doi:10.1016/j.polymdegradstab.2016.08.012

Cited by 48 publications

(32 citation statements)

References 31 publications

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“…Furthermore, materials modified to have positively charged surfaces have many biomedical applications. Such biomedical applications, for example, include chitosan‐HNTs as wound healing material, starch‐HNTs‐peptides as antimicrobial film, tannic acid‐PEI particles as a potent antimicrobial materials or the corresponding ionic liquid forms of these materials such as sucrose microgels for separation of biomacromolecules and various polymeric ILs, which are all promising and capable materials against harmful microorganisms. These antimicrobial materials can inhibit the spread of infections by means of electrostatic interactions with the bacterial cell walls and can destroy the bacterial membranes .…”

Section: Introductionmentioning

confidence: 99%

“…Such biomedical applications, for example, include chitosan‐HNTs as wound healing material, starch‐HNTs‐peptides as antimicrobial film, tannic acid‐PEI particles as a potent antimicrobial materials or the corresponding ionic liquid forms of these materials such as sucrose microgels for separation of biomacromolecules and various polymeric ILs, which are all promising and capable materials against harmful microorganisms. These antimicrobial materials can inhibit the spread of infections by means of electrostatic interactions with the bacterial cell walls and can destroy the bacterial membranes . The main aim of this study is to investigate the antimicrobial capability of PEI‐modified natural HNT and its IL forms containing [Cl] − , [N(CN) 2 ] − , [PF 6 ] − and [BF 4 ] − anions for potential antimicrobial usage against a wide range of microorganisms such as Gram‐negative Escherichia coli ATCC 8739 and Pseudomonas aeruginosa ATCC 10145, Gram‐positive Bacillus subtilis ATCC 6633 and Staphylococcus aureus ATCC 6538, and Candida albicans ATCC 10231 yeast.…”

Section: Introductionmentioning

confidence: 99%

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Functionalization of halloysite nanotubes with polyethyleneimine and various ionic liquid forms with antimicrobial activity

Suner

Şahiner

Akçalı

et al. 2019

J of Applied Polymer Sci

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Halloysite nanotube (HNT), a natural clay, was modified with branched polyethyleneimine (PEI) to form PEI‐HNT using epichlorohydrin (ECH) as coupling agent, then protonated with HCl to obtain H‐PEI‐HNTs providing [NH3]+[Cl]− functionality for potential antimicrobial properties. Upon PEI modification, zeta potential value of HNTs was increased to +37.3 mV from −34.5 mV and to +41.1 mV for H‐PEI‐HNTs. Only 1.87 wt % H‐element in HNT was increased to 3.03 wt % upon PEI modification along with newly generated elements of N and C at 2.99 and 9.93 wt %, respectively. Moreover, ionic liquid (IL) forms of HNTs with [NH3]+[N(CN)2]−, [NH3]+[PF6]− and [NH3]+[BF4]− functionality were generated via anion exchange of H‐PEI‐HNTs with sodium dicyanamide (SDC), ammonium hexafluorophosphate (AHFP), and sodium tetrafluoroborate (STFB). The antimicrobial properties of the modified, protonated, and IL forms of HNTs were determined via macro dilution, diffusion and agar screening tests against Escherichia coli ATCC 8739, Pseudomonas aeruginosa ATCC 10145, Bacillus subtilis ATCC 6633, Staphylococcus aureus ATCC 6538 strains, and Candida albicans ATCC 10231 strains. It was found that H‐PEI‐HNTs possesses potent antimicrobial effect compared with the other forms of HNTs with 2–4 mg mL−1 MIC and 8–16 mg mL−1 MBC values via the macro dilution method. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48352.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Functionalization of halloysite nanotubes with polyethyleneimine and various ionic liquid forms with antimicrobial activity

Suner

Şahiner

Akçalı

et al. 2019

J of Applied Polymer Sci

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“…a) Schematic drawing of tannic acid (TA)/PEI polyplex NGs formed via electrostatic interaction. Reproduced with permission . Copyright 2016, Elsevier Ltd. b) Synthetic procedure to obtain biohybrid NGs via crosslinking in W/O emulsion.…”

Section: Synthesis Of Pei‐based Ng Systemsmentioning

confidence: 99%

“…The electrostatic complexation between PEI and negatively charged materials may allow the facile encapsulation of various biomolecules inside the NGs . For instance, Li et al reported the preparation of bioreducible NGs by electrostatic complexation between the phenolic groups of tannic acid (TA) and the positive charged amine groups of PEI . In their approach, PEI was dissolved in Triton X100/gasoline, then mixed with the water solution of TA with a weight ratio of 1:1 under constant magnetic stirring for 15 min.…”

Section: Synthesis Of Pei‐based Ng Systemsmentioning

confidence: 99%

Polyethylenimine‐Based Nanogels for Biomedical Applications

Zou

Shen

et al. 2019

Macromolecular Bioscience

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Nanogels (NGs) are 3‐dimensional (3D) networks composed of hydrophilic or amphiphilic polymer chains, allowing for effective and homogeneous encapsulation of drugs, genes, or imaging agents for biomedical applications. Polyethylenimine (PEI), possessing abundant positively charged amine groups, is an ideal platform for the development of NGs. A variety of effective PEI‐based NGs have been designed and much effort has been devoted to study the relationship between the structure and function of the NGs. In particular, PEI‐based NGs can be prepared either using PEI as the major NG component or using PEI as a crosslinker. This review reports the recent progresses in the design of PEI‐based NGs for gene and drug delivery and for bioimaging applications with a target focus to tackle the diagnosis and therapy of cancer.

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“…One method for stabilization is to encapsulate the AgNPs in a shell, such as our Ag@TA. Furthermore, TA is also reported to exhibit antibacterial properties . We examined the antibacterial properties by incubating Escherichia coli with the Ag@TA.…”

Section: Introductionmentioning

confidence: 99%

Universal one‐pot, one‐step synthesis of core–shell nanocomposites with self‐assembled tannic acid shell and their antibacterial and catalytic activities

Fang

Tan

Lan

et al. 2017

J of Applied Polymer Sci

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Facile synthesis of metal@polymer nanocomposites were achieved using self-assembled tannic acid (TA) shells without crosslinkers. The TA shell was assembled under mildly alkaline conditions in reaction time of 20 min under constant vortexing. Universal synthesis method was demonstrated by the synthesis of Ag@TA and Au@TA nanocomposites. We propose that the shell formation is due to TA undergoing oxidative self-polymerization to poly(tannic acid) or a supramolecular aggregate of oxidized TA held together by charge transfer, hydrogen bond, and p-p interactions, similar to dopamine polymerization. Gibbs free energy calculations suggest that polymerization is energetically favorable. Synthesized Ag@TA exhibited antibacterial functionality with Escherichia coli minimum inhibitory concentration of 100 mg mL 21 up to 48 h. The population of E. coli was also reduced by 99% within 5 h when incubated with 100 mg mL 21 of Ag@TA nanocomposite. Au@TA also functions as a reduction catalyst. It reduces 4-nitrophenol to 4-aminophenol in the presence of NaBH 4 with a rate constant of k 5 0.63 min 21 lmol 21 . For comparison, using Au nanoparticles yields a rate constant of 0.14 min 21 lmol 21 . The ease of synthesis renders the nanocomposites superior to others, with potential for large-scale application.

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Degradable tannic acid/polyethyleneimine polyplex particles with highly antioxidant and antimicrobial effects

Cited by 48 publications

References 31 publications

Functionalization of halloysite nanotubes with polyethyleneimine and various ionic liquid forms with antimicrobial activity

Functionalization of halloysite nanotubes with polyethyleneimine and various ionic liquid forms with antimicrobial activity

Polyethylenimine‐Based Nanogels for Biomedical Applications

Universal one‐pot, one‐step synthesis of core–shell nanocomposites with self‐assembled tannic acid shell and their antibacterial and catalytic activities

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