Degradable Magnesium Implants—Assessment of the Current Situation

Willumeit‐Römer, Regine; Agha, Nezha Ahmad; Luthringer, Bérengère

doi:10.1007/978-3-319-72332-7_63

Cited by 6 publications

(6 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In vitro studies have shown that an intact cell layer can form a protection layer which can reduce the degradation rate of the material. 51 In addition, the cells can alter the composition of the degradation layer, as was shown for fibroblasts. 51 This becomes quite important when the formation of the degradation layer underneath the bone-forming cells, the osteoblasts, is studied.…”

Section: Degradation In Presence Of Cellsmentioning

confidence: 97%

“…51 In addition, the cells can alter the composition of the degradation layer, as was shown for fibroblasts. 51 This becomes quite important when the formation of the degradation layer underneath the bone-forming cells, the osteoblasts, is studied. Focused ion beam (FIB) milling and analysis of the cross-sections of the degradation layer by energy-dispersive x-ray (EDX) spectroscopy line scans 52 showed that the thickness as well as the composition of the layer are altered.…”

Section: Degradation In Presence Of Cellsmentioning

confidence: 97%

See 1 more Smart Citation

The Interface Between Degradable Mg and Tissue

Willumeit‐Römer

2019

JOM

View full text Add to dashboard Cite

Magnesium (Mg) and its alloys degrade under physiological conditions, which makes them interesting implant materials, especially for osteosynthesis and cardiovascular applications. However, how strong is the connection between the implant, the degradation layer, and the surrounding tissue, namely bone? Considering that microscopically the interface can be separated into the border between the metal and the degradation layer, the degradation layer itself, and the border between the degradation layer and the biological environment, it is not obvious that this zone with total thickness of several tens of microns is sufficient to keep an implant in place. However, biomechanical approaches such as push-out tests have shown that a degraded Mg pin is surprisingly well connected with the bone irrespective of the fragile appearance of the degradation layer. This paper provides an overview of what is known about the interface between degrading Mg implants, cells, and bone tissue.

show abstract

Section: Degradation In Presence Of Cellsmentioning

confidence: 97%

Section: Degradation In Presence Of Cellsmentioning

confidence: 97%

The Interface Between Degradable Mg and Tissue

Willumeit‐Römer

2019

JOM

View full text Add to dashboard Cite

show abstract

“…Concomitantly, modern engineering materials are not only required to excel in a single discipline but are rather expected to stand out in a multitude of properties in order to meet the high standards of pioneering industrial applications. Treated magnesium-based alloys are promising candidates to satisfy a variety of current demands of the automotive industry 3 as well as concerning medical 4 , and battery applications 5,6 .…”

mentioning

confidence: 99%

“…3 Institute of Advanced Ceramics, Hamburg University of Technology, Hamburg, Germany. 4 Institute for Materials Science, Faculty of Engineering, University of Kiel, Kiel, Germany. * email: robert.meissner@tuhh.de…”

mentioning

confidence: 99%

A first-principles analysis of the charge transfer in magnesium corrosion

Würger

Feiler

Vonbun-Feldbauer

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Magnesium is the lightest structural engineering material and bears high potential to manufacture automotive components, medical implants and energy storage systems. However, the practical use of untreated magnesium alloys is restricted as they are prone to corrosion. An essential prerequisite for the control or prevention of the degradation process is a deeper understanding of the underlying corrosion mechanisms. Prior investigations of the formation of gaseous hydrogen during the corrosion of magnesium indicated that the predominant mechanism for this process follows the Volmer–Heyrovský rather than the previously assumed Volmer–Tafel pathway. However, the energetic and electronic states of both reaction paths as well as the charge state of dissolved magnesium have not been fully unraveled yet. In this study, density functional theory calculations were employed to determine these parameters for the Volmer, Tafel and Heyrovský steps to gain a comprehensive understanding of the major corrosion mechanisms responsible for the degradation of magnesium.

show abstract

“…Intense efforts, culminating in a comprehensive list of studies, [ 178 ] have looked at the interface between Mg and the tissue [ 179 ] and controlling the corrosion rate through surface functionalization. [ 180 ] Super‐hydrophobic surfaces have been generated on Mg alloy AZ31 with the expectation of repelling water molecules from the bulk metal—slowing the reaction presented above—and proteins and platelets. [ 181 ] Methods to enhance corrosion resistance while improving biocompatibility include zwitterionic polymer coatings (Figure 5d), [ 182 ] which also introduce non‐thrombogenic surfaces, PLGA coatings (better HUVEC adhesion and spreading), [ 97 ] spin‐coated PLLA and PCL‐Mg, [ 183 ] and silk fibroin coupled with vacuum ultraviolet‐ozone activation treatment to a MgCaZn alloy, resulting in 1 8 −1 slower degradation rate as compared to an uncoated alloy.…”

Section: Bare or Surface‐modified Stentsmentioning

confidence: 99%

Designing Better Cardiovascular Stent Materials: A Learning Curve

Cockerill

See

Young

et al. 2020

Adv Funct Materials

View full text Add to dashboard Cite

Cardiovascular stents are life‐saving devices and one of the top ten medical breakthroughs of the 21st century. Decades of research and clinical trials have taught us about the effects of material (metal or polymer), design (geometry, strut thickness, and the number of connectors), and drug‐elution on vasculature mechanics, hemocompatibility, biocompatibility, and patient health. Recently developed novel bioresorbable stents are intended to overcome common issues of chronic inflammation, in‐stent restenosis, and stent thrombosis associated with permanent stents, but there is still much to learn. Increased knowledge and advanced methods in material processing have led to new stent formulations aimed at improving the performance of their predecessors but often comes with potential tradeoffs. This review aims to discuss the advantages and disadvantages of stent material interactions with the host within five areas of contrasting characteristics, such as 1) metal or polymer, 2) bioresorbable or permanent, 3) drug elution or no drug elution, 4) bare or surface‐modified, and 5) self‐expanding or balloon‐expanding perspectives, as they relate to pre‐clinical and clinical outcomes and concludes with directions for future studies.

show abstract

Degradable Magnesium Implants—Assessment of the Current Situation

Cited by 6 publications

References 30 publications

The Interface Between Degradable Mg and Tissue

The Interface Between Degradable Mg and Tissue

A first-principles analysis of the charge transfer in magnesium corrosion

Designing Better Cardiovascular Stent Materials: A Learning Curve

Contact Info

Product

Resources

About