Degradable cross-linked polymer vesicles for the efficient delivery of platinum drugs

Abstract

Nontoxic and acid-degradable polymer vesicles were synthesized as drug carriers. In vitro dose–response cytotoxicity studies suggested that the drug-loaded polymer vesicles were more efficient in delivering cis-platin into cancer cells compared to the internalization of the free drug.

Polymer Nanocontainers for Intracellular Delivery

“…The linear brush diblock copolymer poly(ONBAn n ‐ b ‐ONB‐PEG m ) (ONBAn n =oxanorbornenyl anhydride, ONB=ω‐oxanorbornenyl) synthesised by ring‐opening metathesis polymerisation self‐assembled into polymeric vesicles. The polymer bilayer was cross‐linked using an acid‐sensitive diamino ketal cross‐linker, and the anticancer drug cisplatin was conjugated in the bilayer . The cross‐linked vesicle protected the drug at physiological pH 7.4 and efficiently released the payload in the acidic lysosome with pH 5.5 (Figure ).…”

“… Preparation of cross‐linked cisplatin‐conjugated vesicles. Reproduced with permission . Copyright 2015, Royal Society of Chemistry.…”

Crosslinked polymeric self-assemblies as an efficient strategy for photodynamic therapy on a 3D cell culture

“…12,13 Even if the subject has been studied for over 15 years, new cases are still being published, with different crosslinking methods, such as radical reactions, [14][15][16][17] reversible disulde bonds, [18][19][20][21][22][23][24] or coupling reactions. [25][26][27][28][29][30][31][32][33][34][35][36] Original approaches have used uracyl moieties, 37 dopamine oxidation in the presence of air 38 or cinnamate reversible dimerization. 39 More sophisticated systems present a crosslinking enabling the release of the drug with adequate physiological conditions (presence of dithiothreitol or glutathione, difference of pH).…”

“…39 More sophisticated systems present a crosslinking enabling the release of the drug with adequate physiological conditions (presence of dithiothreitol or glutathione, difference of pH). 18,[21][22][23][24][25]27,34,35,[40][41][42] Interestingly, Rajdev showed that Hbonding between hydroxyl groups in poly(hydroxyethyl methacrylate) could be used as supramolecular crosslinking. 43 The same concept could be suggested for micelles exhibiting a large amount of p-p stacking.…”

Amphiphilic core cross-linked star polymers as water-soluble, biocompatible and biodegradable unimolecular carriers for hydrophobic drugs

“…For example, drug carriers formed via self-assembly of amphiphilic block copolymers in aqueous solutions, such as micelles and vesicles, have been proposed. [10][11][12][13][14] Although covalent stabilization of micelles and vesicles has been attempted to prevent their dissociation, [15][16][17] this introduces additional complexity. A change in environmental conditions allows manipulation of the size and morphology of these aggregates, besides the molecular weight and block length ratios of the copolymers, which are easily tuned.…”