Degradable Cisplatin-Releasing Core-Shell Nanogels from Zwitterionic Poly(β -Aminoester)-Graft-PEG for Cancer Chemotherapy

Jin, Wei; Xu, Pao; Zhan, Yihong; Shen, Youqing; Kirk, Edward A. Van; Alexander, Brenda M.; Murdoch, William J.; Liu, Lijian; Isaak, Dale D.

doi:10.1080/10717540601036856

Cited by 26 publications

(18 citation statements)

References 40 publications

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“…[79, 80] Such nanogels have a cross-linked polyanion (PMA) core and nonionic polymer (PEG) corona. In aqueous solutions cisplatin reacts with the carboxylic groups in the nanogels core, which leads to formation a condensed drug-loaded core.…”

Section: Nanogel Loading With Drug and Drug Releasementioning

confidence: 99%

“…[100] In particular, synthetic polymers were shown to interact with some drug transport systems and activate selected cell signaling pathways, and this was shown to alter pharmacological, genomic and immune responses to biological agents. [79, 80] Along the similar lines Frechet and colleagues used acid-degradable nanogels for antigen presentation in vitro and vaccination in vivo . [17, 19, 101-103] They have shown that nanogels can be designed to generate immune responses when delivered to phagocytic cells of the immune system for vaccine development.…”

Section: Delivery Of Biomacromolecules Using Nanogelsmentioning

confidence: 99%

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Nanogels as Pharmaceutical Carriers: Finite Networks of Infinite Capabilities

2009

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Nanogels are swollen nano-sized networks composed of hydrophilic or amphiphilic polymer chains, which can be non-ionic or ionic. They are developed as carriers for drug delivery and can be designed to spontaneously absorb biologically active molecules through formation of salt bonds, hydrogen bonds, or hydrophobic interactions. Polyelectrolyte nanogels can readily incorporate oppositely charged low molecular mass drugs or biomacromolecules such as oligonucleotides, siRNA, DNA and proteins, which bind with the nanogel ionic chains and phase separate within the finite nanogel volume. As a result, the loading capacity of such nanogels is superior to most other drug carriers. Binding of the drugs induces collapse of nanogel, which usually decreases the volume by at least one order of magnitude. However, the drug-nanogel particles remain dispersed due to the lyophilizing effect of nanogel's hydrophilic polymer chains, such as poly(ethylene glycol) exposed at the particle surface. Multiple chemical functionalities of nanogels can be employed for introduction of imaging labels, targeting molecules and triggered drug release capabilities such as stimuli-responsive and degradable cross-links. Recent studies suggested several promising biomedical applications of nanogels, including drug delivery of phosphorylated nucleoside analogs, oligonucleotides or siRNA for anticancer or antiviral treatment, encapsulation of bioactive proteins, fabrication of nanometallic or nanoceramic composites, imaging agents, oral and CNS drug delivery. The research of different functional nanogels as novel pharmaceutical carriers for diagnosis and therapy shows promise and is rapidly developing.

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Section: Nanogel Loading With Drug and Drug Releasementioning

confidence: 99%

Section: Delivery Of Biomacromolecules Using Nanogelsmentioning

confidence: 99%

Nanogels as Pharmaceutical Carriers: Finite Networks of Infinite Capabilities

2009

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“…[79,80] Diese Nanogele bestehen aus einem vernetzten anionischen PMA-Kern und einer nichtionischen PEG-Hülle. In wässriger Umgebung reagiert Cisplatin mit den Carboxylatgruppen im Kern des Gels, was zum Kollaps des beladenen Kerns führt.…”

Section: Beladen Von Nanogelen Mit Wirkstoffen Und Deren Freisetzungunclassified

“…Dies verändert die Pharmakologie, Pharmakogenomik und Immunogenität biologisch aktiver Wirkstoffe. [79,80] Entsprechend wurden von FrØchet und Mitarbeitern säurelabile Nanogele zur Antigenpräsentation in vitro und zur Impfung in vivo eingesetzt. [17,19,[101][102][103] Sie zeigten, dass Nanogele für die Erzeugung einer Immunantwort maßge-schneidert werden können, indem sie phagozytotischen Zellen des Immunsystems zugeführt werden.…”

Section: Angewandte Chemieunclassified

Nanogele als pharmazeutische Trägersysteme: winzige Netzwerke mit großen Möglichkeiten

Kabanov

Vinogradov

2009

Angewandte Chemie

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Als Nanogele bezeichnet man gequollene Netzwerke aus hydrophilen oder amphiphilen Polymeren in der Größenordnung von einigen Dutzend bis Hundert Nanometern. Sie wurden als Trägersysteme für den Transport von Wirkstoffen entwickelt. Durch gezieltes Design können biologisch aktive Moleküle spontan eingebunden werden, sei es mithilfe von Salzbrücken, Wasserstoffbrücken oder hydrophoben Wechselwirkungen. Polyelektrolyt‐Nanogele sind in der Lage, gegensätzlich geladene niedermolekulare Wirkstoffe und Biomakromoleküle wie Oligo‐ und Polynucleotide (siRNA, DNS) sowie Proteine aufzunehmen. Die Gastmoleküle wechselwirken elektrostatisch mit den ionischen Polymerketten des Gels und werden dadurch in den winzigen Nanogelen gebunden. Zahlreiche chemische Funktionalitäten stehen zur Verfügung, um Gruppen für Bildgebungsverfahren und den gezielten Wirkstofftransport im Nanogel einzuführen. Letzteres kann z. B. durch abbaubare oder schaltbare Vernetzungen erreicht werden. Aktuelle Arbeiten zeichnen eine aussichtsreiche Zukunft für biomedizinische Anwendungen von Nanogelen.

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“…Particle size and the PDI are important factors for the nanocarriers, which can influence the distribution of carriers (Jin et al, 2007). Particle size lower than 200 nm could decreases uptake by the liver, prolongs circulation time in the blood and improves bioavailability.…”

Section: Characterization Of Drug-loaded Nlcsmentioning

confidence: 99%

Folate-modified, cisplatin-loaded lipid carriers for cervical cancer chemotherapy

et al. 2015

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Background: Cervical cancer chemotherapy calls for the efficiently delivery of anticancer drug into cancer cells by nanoparticles. In this study, folate (FA) modified, cisplatin (CIS)-loaded nanostructured lipid carriers (NLCs) were constructed and evaluated. Methods: FA containing polyethylene glycol (PEG)-distearoylphosphatidylethanolamine (DSPE) (FA-PEG-DSPE) was synthesized. FA-PEG-DSPE modified, CIS-loaded NLCs (FA-CIS-NLCs) were prepared. Their particle size, zeta potential, drug encapsulation efficiency (EE) and in vitro delivery behavior were evaluated. In vitro cytotoxicity study of FA-CIS-NLCs was tested in human cervix adenocarcinoma cell line (HeLa cells). In vivo anti-tumor efficacies of the carriers were evaluated on a mice-bearing cervical cancer model.

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Degradable Cisplatin-Releasing Core-Shell Nanogels from Zwitterionic Poly(β -Aminoester)-Graft-PEG for Cancer Chemotherapy

Cited by 26 publications

References 40 publications

Nanogels as Pharmaceutical Carriers: Finite Networks of Infinite Capabilities

Nanogels as Pharmaceutical Carriers: Finite Networks of Infinite Capabilities

Nanogele als pharmazeutische Trägersysteme: winzige Netzwerke mit großen Möglichkeiten

Folate-modified, cisplatin-loaded lipid carriers for cervical cancer chemotherapy

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