Dégénérescences rétinienne et trabéculaire dans le glaucome : pathogenèse et perspectives thérapeutiques

Denoyer, Alexandre; Sapienza, Anaïs; Goazigo, Annabelle Réaux‐Le; Mélik-Parsadaniantz, Stéphane; Baudouin, Christophe

doi:10.1016/j.jfo.2014.11.004

Cited by 4 publications

(2 citation statements)

References 65 publications

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“…The major features of glaucoma include progressive cell death of retinal ganglions and optic nerve damage 48 ,which are usually induced by loss of neurotrophic factors, intracellular and extracellular toxicity of glutamate, and neuro-inflammation 48–52 . In the nervous system, H 2 S functions as neurotransmitters 53 and possesses the ability to inhibit apoptosis and degradation of neurons 54 .…”

Section: Generation Of H2s In Ocular Tissuesmentioning

confidence: 99%

Hydrogen sulfide: a gaseous signaling molecule modulates tissue homeostasis: implications in ophthalmic diseases

et al. 2019

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Hydrogen sulfide (H 2 S) serves as a gasotransmitter in the regulation of organ development and maintenance of homeostasis in tissues. Its abnormal levels are associated with multiple human diseases, such as neurodegenerative disease, myocardial injury, and ophthalmic diseases. Excessive exposure to H 2 S could lead to cellular toxicity, orchestrate pathological process, and increase the risk of various diseases. Interestingly, under physiological status, H 2 S plays a critical role in maintaining cellular physiology and limiting damages to tissues. In mammalian species, the generation of H 2 S is catalyzed by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), 3-mercapto-methylthio pyruvate aminotransferase (3MST) and cysteine aminotransferase (CAT). These enzymes are found inside the mammalian eyeballs at different locations. Their aberrant expression and the accumulation of substrates and intermediates can change the level of H 2 S by orders of magnitude, causing abnormal structures or functions in the eyes. Detailed investigations have demonstrated that H 2 S donors’ administration could regulate intraocular pressure, protect retinal cells, inhibit oxidative stress and alleviate inflammation by modulating the function of intra or extracellular proteins in ocular tissues. Thus, several slow-releasing H 2 S donors have been shown to be promising drugs for treating multiple diseases. In this review, we discuss the biological function of H 2 S metabolism and its application in ophthalmic diseases.

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Section: Generation Of H2s In Ocular Tissuesmentioning

confidence: 99%

Hydrogen sulfide: a gaseous signaling molecule modulates tissue homeostasis: implications in ophthalmic diseases

et al. 2019

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“…Here we review the key contributors to the high energy demands in the retina and the distinguishing features of energy metabolism of retinal neurons. The major features of glaucoma include progressive cell death of retinal ganglions and optic nerve damage [28]. The focus of this review is, therefore, on the energetic budget of the retinal ganglion cells, optic nerve and the relevant cells that surround them.…”

Section: Introductionmentioning

confidence: 99%

Energy Metabolism in the Inner Retina in Health and Glaucoma

Liu

Prokosch

2021

IJMS

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Glaucoma, the leading cause of irreversible blindness, is a heterogeneous group of diseases characterized by progressive loss of retinal ganglion cells (RGCs) and their axons and leads to visual loss and blindness. Risk factors for the onset and progression of glaucoma include systemic and ocular factors such as older age, lower ocular perfusion pressure, and intraocular pressure (IOP). Early signs of RGC damage comprise impairment of axonal transport, downregulation of specific genes and metabolic changes. The brain is often cited to be the highest energy-demanding tissue of the human body. The retina is estimated to have equally high demands. RGCs are particularly active in metabolism and vulnerable to energy insufficiency. Understanding the energy metabolism of the inner retina, especially of the RGCs, is pivotal for understanding glaucoma's pathophysiology. Here we review the key contributors to the high energy demands in the retina and the distinguishing features of energy metabolism of the inner retina. The major features of glaucoma include progressive cell death of retinal ganglions and optic nerve damage. Therefore, this review focuses on the energetic budget of the retinal ganglion cells, optic nerve and the relevant cells that surround them.

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Thérapie cellulaire par cellules souches mésenchymateuses, un nouvel espoir pour les pathologies oculaires

Denoyer

Brignole‐Baudouin

2015

Journal Français d'Ophtalmologie

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Dégénérescences rétinienne et trabéculaire dans le glaucome : pathogenèse et perspectives thérapeutiques

Cited by 4 publications

References 65 publications

Hydrogen sulfide: a gaseous signaling molecule modulates tissue homeostasis: implications in ophthalmic diseases

Hydrogen sulfide: a gaseous signaling molecule modulates tissue homeostasis: implications in ophthalmic diseases

Energy Metabolism in the Inner Retina in Health and Glaucoma

Thérapie cellulaire par cellules souches mésenchymateuses, un nouvel espoir pour les pathologies oculaires

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