Degenerative Effect of Cisplatin on Testicular Germinal Epithelium

Mohammadnejad, Daryoush; Abedelahi, Ali; Soleimanirad, Jafar; Mohammadi-roshandeh, Ameneh; Rashtbar, M; Azami, Aida

doi:10.5681/apb.2012.026

Cited by 16 publications

(3 citation statements)

References 28 publications

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“…PAS-stained sections of the Cis group revealed thickening of the basement membrane, which was confirmed by TEM results. Similar findings were described by other researchers[ 18 ] who attributed the thickening to either increased production of the basement membrane by Sertoli and myoid cells or decreased proteolysis rate in the extracellular matrix.…”

Section: Discussionsupporting

confidence: 91%

“…The detected corrugation of the basement membrane appeared in our study, could be the result of myoid cell contraction or the reduction of tubular diameter. [ 18 ] This contraction might be the result of increased endothelin-1 protein produced by endothelial cells and vascular smooth muscle cells. [ 19 ] It was found that Cis caused a significant increase in this protein production in the testicular tissues of adult male Wistar rats.…”

Section: Discussionmentioning

confidence: 99%

“…[ 21 ] The germinal epithelium vacuolated cytoplasm could be attributed to lipid peroxidation caused by Cis. Moreover, the detachment of the germinal epithelium cells from the basement membrane and from each other could be attributed to different mechanisms such as loss of cadherin, damage of the blood–testis barrier tight junctions caused by lipid peroxidation,[ 16 18 ] and the reduction in testosterone hormone required for the attachment of different generations of germ cells within the seminiferous tubules. [ 22 ]…”

Section: Discussionmentioning

confidence: 99%

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The effect of selenium nanoparticles versus royal jelly against cisplatin-induced testicular toxicity in adult male albino rats: A light and transmission electron microscopic study

Mohammed

Eisa²,

El-Aziz³

et al. 2022

J Microsc Ultrastruct

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Background and Aim: Cisplatin (Cis) is a highly effective chemotherapeutic agent. However, it produces severe testicular toxicity. It was reported that some antioxidants could overcome this toxicity. Selenium nanoparticles and royal jelly (RJ) were among these reported antioxidants. Therefore, this study was designed to compare these two antioxidants in protecting the testes against Cis-induced toxicity. Materials and Methods: This study was conducted on sixty healthy adult male albino rats (weight: 200–220 g) randomized into six groups, ten animals each. Group I (control), Group II (animals received intragastric Nano Selenium), Group III (animals received intragastric RJ), Group IV (animals received an IP injection of Cis 7 mg/kg), Group V (animals received intragastric Nano Selenium, and Cis injection), and Group VI (animals received intragastric RJ and Cis injection). After 10 days, the animals were sacrificed by cervical decapitation. The testes were weighted, and specimens from the left testis were processed for histological and immunohistochemical techniques, whereas specimens from the right testes were prepared for transmission electron microscopic examination. Results: Cis-treated animals had significantly reduced weight of their testes. Light microscopic examination revealed severe histopathological changes in the germinal epithelium and Leydig cells, confirmed with electron microscopic examination. There was a significant increase in the color area percentage of Caspase-3 immunostaining of the germinal epithelium and Leydig cells, compared to that of the control group. Group II and III were similar to control group. Both Groups V and VI revealed significant preservation compared to the Cis group. Conclusion: Selenium nanoparticles and RJ partially improved testis from Cis-induced toxicity, However, there was no significant difference between both groups.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The effect of selenium nanoparticles versus royal jelly against cisplatin-induced testicular toxicity in adult male albino rats: A light and transmission electron microscopic study

Mohammed

Eisa²,

El-Aziz³

et al. 2022

J Microsc Ultrastruct

View full text Add to dashboard Cite

show abstract

Assessment of the effect of sodium hydrogen sulfide (hydrogen sulfide donor) on cisplatin-induced testicular toxicity in rats

Azarbarz

Seifabadi

Moaiedi

et al. 2020

Environ Sci Pollut Res

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Biochemical changes associated with ascorbic acid–cisplatin combination therapeutic efficacy and protective effect on cisplatin-induced toxicity in tumor-bearing mice

Amenla

Prasad

2015

Toxicology Reports

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Cisplatin is one of the well-established anticancer drugs being used against a wide spectrum of cancers. However, full therapeutic efficacy of the drug is limited due to development of various toxicities in the host. This study examines the comparative therapeutic effectiveness and toxicities of cisplatin alone and in combination of dietary ascorbic acid (AA) in ascites Dalton's lymphoma-bearing mice. The findings show that the combination treatment of mice with ascorbic acid plus cisplatin has much better therapeutic efficacy against murine ascites Dalton's lymphoma (DL) in comparison to cisplatin alone and this may involve a decrease in reduced glutathione (GSH), catalase activity and increased lipid peroxidation (LPO) in Dalton's lymphoma tumor cells. At the same time, combination treatment indicates a protective role of ascorbic acid against cisplatin-induced tissue toxicities (side effects) in the hosts. Cisplatin-induced histopathological changes in liver, kidney and testes were decreased after combination treatment. The analysis of renal function test (RFT), liver function test (LFT) and sperm abnormalities also suggest an improvement in these parameters after combination treatment. Therefore, it may be concluded that the increased GSH level, catalase activity and decreased LPO in the tissues, i.e., liver, kidney and testes after combination treatment may be involved in its protective ability against cisplatin-induced tissue toxicities in the host.

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Degenerative Effect of Cisplatin on Testicular Germinal Epithelium

Cited by 16 publications

References 28 publications

The effect of selenium nanoparticles versus royal jelly against cisplatin-induced testicular toxicity in adult male albino rats: A light and transmission electron microscopic study

The effect of selenium nanoparticles versus royal jelly against cisplatin-induced testicular toxicity in adult male albino rats: A light and transmission electron microscopic study

Assessment of the effect of sodium hydrogen sulfide (hydrogen sulfide donor) on cisplatin-induced testicular toxicity in rats

Biochemical changes associated with ascorbic acid–cisplatin combination therapeutic efficacy and protective effect on cisplatin-induced toxicity in tumor-bearing mice

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