Degenerative Collagenous Plaques of the Hands

Ritchie, Earl B.

doi:10.1001/archderm.1966.01600200058008

Cited by 27 publications

(12 citation statements)

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“…Collagen fiber changes are obvious. Altered connective areas are almost acellular; 1–4 however, some fibroblasts with pyknotic nuclei may be identified. As fibroblasts model collagen fibers, probably through enzymatic mechanisms (collagenase release?…”

Section: Discussionmentioning

confidence: 99%

“…DCPH has been described as a degenerative collagenous process 1 and almost simultaneously as a circumscribed keratoderma variant. 8 It has also been reported as a senile elastosis variant 3 and a keratoelastoidosis secondary to chronic pressure in manual workers. 9 Mehregan 2 pointed out, however, that a combination of long‐term trauma and pressure, with some degree of actinic exposure, may be responsible for DCPH.…”

Section: Discussionmentioning

confidence: 99%

“…Degenerative collagenous plaques of the hands (DCPH) 1–4 and acrokeratoelastoidosis (AKE) 5,6–7 are two pathogenically controversial and confusing dermatoses characterized by acral, symmetric, hyperkeratotic lesions, most frequently on the hands, associated with dermal connective tissue abnormalities. Burks et al .…”

Section: Introductionmentioning

confidence: 99%

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Degenerative collagenous plaques of the hands and acrokeratoelastoidosis: pathogenesis and relationship with knuckle pads

Abulafia

Vignale

2000

Int J Dermatology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Degenerative collagenous plaques of the hands and acrokeratoelastoidosis: pathogenesis and relationship with knuckle pads

Abulafia

Vignale

2000

Int J Dermatology

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“…In 1960, five patients with a characteristically distributed dermal alteration of collagen and elastin were reported, 1 a condition the authors named ‘degenerative collagenous plaques of the hands’, a designation used in subsequent publications 2,3 . Later, the alternate term ‘keratoelastoidosis marginalis’ was proposed 4 .…”

Section: Discussionmentioning

confidence: 99%

Collagenous and elastotic marginal plaques of the hands

Mortimore

Conrad

2001

Aust J Dermatology

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A 49-year-old woman presented with an asymptomatic indurated linear plaque extending from the medial surface of the right thumb along the junction of the dorsal and palmar skin of the hand onto the lateral aspect of the index finger. The left hand showed a similar but less extensive plaque. A skin biopsy showed an acellular zone in the reticular dermis composed of thickened bundles of collagen haphazardly arranged, some perpendicular to the epidermis, admixed with elastic fibres and amorphous basophilic elastotic material. Granular calcium deposits were identified, particularly within degenerate collagen bundles. These clinical and histological features are diagnostic of collagenous and elastotic marginal plaques of the hands, a slowly progressive but largely asymptomatic condition. Actinic degeneration and chronic pressure have been proposed as aetiological agents, but our patient did not exhibit marked actinic degeneration and had no history of chronic occupational pressure.

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“…2,[4][5][6][7][8][9] The youngest patient reported to date is a female in her early 40s. 6 Both males and females are affected, but males are reportedly more commonly affected.…”

Section: Discussionmentioning

confidence: 99%