Degenerative changes in the knee after meniscectomy.

Jackson, J. P.

doi:10.1136/bmj.2.5604.525

Cited by 264 publications

(98 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…From the late 1960s to the 1980s there are an increasing number of follow-up reports of total meniscectomy published, and they all indicate a high frequency of radiographic changes and reduced knee function (Gear 1967, Jackson 1968, Tapper and Hoover 1969, Appel 1970, Johnson et al 1974, Noble 1975, Noble and Erat 1980, SonneHolm et al 1980, Lotke et al 1981, Doherty et al 1983, Allen et al 1984, Jørgensen et al 1987. However, the actual increase in risk of OA after total meniscectomy was for long unknown.…”

Section: Total Meniscectomymentioning

confidence: 99%

Meniscal tear - a feature of osteoarthritis

Englund¹

2004

SORT

View full text Add to dashboard Cite

Meniscectomy is recognized as an important risk factor for the development of knee osteoarthritis (OA), a disease that traditionally has been considered as a simple "wear and tear" phenomenon. However, despite numerous reports, little evidence has been presented that a limited meniscal resection, compared with a more extensive resection, reduces the risk of OA by preserving meniscal function. Why? This thesis provides one possible answer to that question.Patients, who had undergone isolated meniscal resection in 1973, 1978, or between 1983 and 1985 at Lund University Hospital, Sweden, were reviewed clinically and radiographically 15-22 years after the surgical procedure.Of the subjects (n = 317) almost 50% had developed radiographic OA in their operated knee, but just over half of these patients were symptomatic. An additional 20% of the patients had knee symptoms, but did not have radiographic knee OA. These results confi rm a limited correlation between radiographic features of the disorder and symptoms.A degenerative type of meniscal tear and obesity were the factors most strongly associated with both radiographic knee OA and symptomatic radiographic knee OA.Partial meniscal resection induced less radiographic changes related to knee OA compared with total meniscectomy, but the patient-relevant outcomes remained essentially the same.If radiographic hand OA was present there was an increased likelihood of the patient also having knee OA following meniscectomy. This fi nding was independent of age, and therefore an inherited susceptibility to the disease contributes to the risk of knee OA after meniscal tear. Genetic and environmental risk factors interact in OA development.A degenerative meniscal lesion is often associated with early-stage knee OA, a disorder also involving the meniscal tissue. The tear may thus represent the fi rst "signal" feature of OA. The challenge for the health professional is to discriminate between symptoms caused by a meniscal tear and those caused by OA. Meniscal resection may not benefi t the patient with early-stage knee OA. The intervention merely removes evidence of the disorder, while the OA joint degradation proceeds.

show abstract

Section: Total Meniscectomymentioning

confidence: 99%

Meniscal tear - a feature of osteoarthritis

Englund¹

2004

SORT

View full text Add to dashboard Cite

show abstract

“…As a consequence, surgery is less demanding and immunosuppressive therapy is not needed (Jackson et al, 1992). Meniscal transplantation is actually the only biologic option available for the symptomatic, totally meniscectomised, non-osteoarthritic, stable and wellaligned knee Lubowitz et al, 2007).…”

Section: Meniscal Transplantationmentioning

confidence: 99%

“…Due in large part to the limited vascularity of the meniscus, which is restricted to the external third, this tissue has a poor healing potential (Arnoczky and Warren, 1982;Arnoczky and Warren, 1983). Although common in the past, total meniscectomy has been largely abandoned, for the direct relationship between meniscectomy and development of early osteoarthritis (Allen et al, 1984;Appel, 1970;Berjon et al, 1991;Ghosh et al, 1990;Hoch et al, 1983;Huckell, 1965;Jackson, 1968;Lufti, 1975;Northmore-Ball and Dandy, 1982;Voloshin and Wosk, 1983). Partial meniscectomy is still indicated if the lesion cannot be satisfactorily sutured (Sommerlath, 1991;Shelbourne and Carr, 2003).…”

Section: Introductionmentioning

confidence: 99%

Meniscus repair and regeneration: review on current methods and research potential

Scotti

Hirschmann

Antinolfi

et al. 2013

eCM

126

123

View full text Add to dashboard Cite

Meniscus regeneration is an unsolved clinical challenge. Despite the wide acceptance of the degenerative consequences of meniscectomy, no surgical procedure has succeeded to date in regenerating a functional and long-lasting meniscal fibrocartilage. Research proposed a number of experimental approaches encompassing all the typical strategies of regenerative medicine: cellfree scaffolds, gene therapy, intra-articular delivery of progenitor cells, biological glues for enhanced bonding of reparable tears, partial and total tissue engineered meniscus replacement. None of these approaches has been completely successful and can be considered suitable for all patients, as meniscal tears require specific and patientrelated treatments depending on the size and type of lesion. Recent advances in cell biology, biomaterial science and bioengineering (e.g., bioreactors) have now the potential to drive meniscus regeneration into a series of clinically relevant strategies. In this tutorial paper, the clinical need for meniscus regeneration strategies will be explained, and past and current experimental studies on meniscus regeneration will be reported.

show abstract

“…However, longer-term studies indicate that, very often, there are complications after meniscectomy (5-12). The most frequent and debilitating of such complications is precocious osteo,arthritis in the joint (10,12,13). In an attempt to…”

mentioning

confidence: 99%

In vitro cell proliferation and proteoglycan synthesis of rabbit meniscal fibrochondrocytes as a function of age and sex

Webber

Zitaglio

Hough

1986

Arthritis & Rheumatism

View full text Add to dashboard Cite

Meniscal fibrochondrocytes from male and female New Zealand white rabbits, ages 6, 12, and 24 months, were grown in primary and secondary monolayer cell culture. Neither age nor sex affected the majority of their cell culture characteristics. Cells from young males (6 months old) synthesized greater amounts of sulfated proteoglycans than did those from young females, but by 2 years of age, this result was reversed. All age groups synthesized 2 classes of proteoglycans, based on hydrodynamic size, but the ratio of the 2 classes changed as a function of age. Overall, the meniscal fibrochondrocytes from both skeletally immature and skeletally mature rabbits of both sexes were capable of proliferation and matrix synthesis in vitro.One of the most frequently performed orthopedic operations is knee joint arthrotomy with meniscectomy. The frequent and widespread use of this procedure was encouraged by early reports of successful postoperative results (1-4). However, longer-term studies indicate that, very often, there are complications after meniscectomy (5-12). The most frequent and debilitating of such complications is precocious osteo,arthritis in the joint (10,12,13). In an attempt to

show abstract

Degenerative changes in the knee after meniscectomy.

Cited by 264 publications

References 2 publications

Meniscal tear - a feature of osteoarthritis

Meniscal tear - a feature of osteoarthritis

Meniscus repair and regeneration: review on current methods and research potential

In vitro cell proliferation and proteoglycan synthesis of rabbit meniscal fibrochondrocytes as a function of age and sex

Contact Info

Product

Resources

About