Degenerative Changes in Maculas of Rhesus Monkeys

Engel, Harry M.; Dawson, William W.; Ulshafer, Robert J.; Hines, Michael W.; Kessler, Matthew J.

doi:10.1159/000309891

Cited by 29 publications

(20 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This may reflect either a slower degenerative process, or may represent an environmentally selective phenomenon [11]. Furthermore, we did not find any BLD in the maculae of these monkeys, which is consistent with findings of other studies [11,21,46,49]. This might implicate a degenerative process in the rhesus monkey eye somewhat different from that in the human eye.…”

Section: Discussionsupporting

confidence: 91%

“…Aged maculae of rhesus monkeys have clinically and histologically detectable pathology associated with age-related maculopathy (ARM). Clinically, macular drusen (6 to 74%) identical to human drusen, and alterations of the RPE (18 to 45%) have been demonstrated [11,20,34,46,49]. The maximum life span of the rhesus monkey is one third of humans implying that relative aging occurs three times more rapidly [36].…”

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Apoptosis is present in the primate macula at all ages

Lambooij¹,

Kliffen

Kuijpers³

et al. 2000

Graefe's Arch Clin Exp Ophthalmol

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 98%

Apoptosis is present in the primate macula at all ages

Lambooij¹,

Kliffen

Kuijpers³

et al. 2000

Graefe's Arch Clin Exp Ophthalmol

View full text Add to dashboard Cite

show abstract

“…This female was from a matriline with a low incidence of ocular hypertension. Relatively rapid aging (3)(4) years/human year) monkeys with ocular hypertension and familial clustering produce a near ideal glaucoma research model. (BrJ Ophthalmol 1993;77: 302-310) Since 1984, with the cooperation ofthe University of Puerto Rico, we have had a number of opportunities to examine members of the Cayo Santiago rhesus monkey colony for diseases of the posterior segment of the eye.…”

Section: Introductionmentioning

confidence: 99%

Primary open angle glaucomas in the rhesus monkey.

Dawson

Brooks

Hope

et al. 1993

British Journal of Ophthalmology

View full text Add to dashboard Cite

Rhesus monkeys from the closed Cayo Santiago colony of the University of Puerto Rico demonstrate elevated (.22 mm Hg) intraocular pressure in a pattern which significantly favours certain maternal lineage groupings. The colony had remained genetically pure since 1938. Of nine matriarchal lineages (matrilines) examined, two had an incidence of ocular hypertension of more than 40% and six of more than 10%. Information on 18 matrilines is currently located in the colony data base which identifies each individual and its vital statistics. In 1990, six animals were moved to the laboratory in Florida. Among those from a low incidence matriline, we found abnormal optic nerve cups, pallor, reduced function of (mainly peripheral) fields, progression and loss of optic nerve axons in the presence of ocular hypertension. In another individual where the cup/disc ratio for the right eye was 0 7 and left eye 0*4 and outflow facility was normal, we excluded all other causes of optic nerve atrophy, and low tension glaucoma was diagnosed. This female was from a matriline with a low incidence of ocular hypertension. Relatively rapid aging (3-4 years/human year) monkeys with ocular hypertension and familial clustering produce a near ideal glaucoma research model.

show abstract

“…The tuning peaks were much less pronounced in the abnormal eyes and extrapolated thresholds were about 8 min arc. One set of functions from E-9 have been pictured in a prior publication [4].…”

Section: Resultsmentioning

confidence: 99%

Macular disease in related rhesus monkeys

et al. 1989

View full text Add to dashboard Cite

During (January) 1986-(May) 1988, we examined 272 eyes in 136 rhesus monkeys in the closed Cayo Santiago colony of the Caribbean Primate Research Center of the University of Puerto Rico. Seventy-eight eyes were less than 10 years of age. One hundred and ninety-four were aged 10-28 years. The fundi were examined and photographed. Fluorescein angiography was performed in some eyes. Selected cases were evaluated for 'acuity' loss by recording of pattern-evoked retinal and cortical signals. Light and electron microscopy were used to evaluate the pigment epithelium of some animals. Thirty-eight percent of all eyes had posterior pole drusen. Incidence was highly age-related. When late-stage lesions were found, we did not see neovascularization, but late hyperfluorescence was consistent with degenerative scarring and atrophy. Electrophysiology demonstrated moderately reduced acuity in the presence of numerous macular drusen. Electrooculograms were low normal. Histopathology showed changes identical to those reported in human age-related macular degeneration. No eyes less than 10 years of age had confluent drusen or disciform-like lesions. The incidence of drusen in samples of some social groups was much higher than others.

show abstract

Degenerative Changes in Maculas of Rhesus Monkeys

Cited by 29 publications

References 9 publications

Apoptosis is present in the primate macula at all ages

Apoptosis is present in the primate macula at all ages

Primary open angle glaucomas in the rhesus monkey.

Macular disease in related rhesus monkeys

Contact Info

Product

Resources

About