Degeneration of white matter and gray matter revealed by diffusion tensor imaging and pathological mechanism after spinal cord injury in canine

Liu, Changbin; Yang, Degang; Xin, Zhang; Zhang, Wenhao; Li, Dapeng; Zhang, Chao; Qin, Chuan; Du, Liyong; Li, Jun; Gao, Feng; Zhang, Jie; Zuo, Zhentao; Yang, Mingliang; Li, Jianjun

doi:10.1111/cns.13044

Cited by 11 publications

(10 citation statements)

References 39 publications

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“…Within the gray matter, the principally cellular microstructure typically has predominant isotropic diffusion characteristics that are best evaluated by apparent diffusion coefficient (ADC) maps . However, multiple studies have shown that FA values, markers of anisotropic diffusion, may also alter the microstructural anatomy if affected by a diffuse process . For example, in patients with a cortical stroke, the FA values may increase within the cortical gray matter, likely secondary to a combination of cytotoxic and vasogenic edema impacting the diffusion of water molecules within the extracellular space .…”

Section: Discussionmentioning

confidence: 99%

Characterization of the Basal Ganglia Using Diffusion Tensor Imaging in Children with Self‐Injurious Behavior and Tuberous Sclerosis Complex

Gipson

Poretti

Kelley

et al. 2019

Journal of Neuroimaging

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BACKGROUND AND PURPOSE Tuberous sclerosis complex (TSC) is a rare, genetic disease that is associated with multiple manifestations including epilepsy and autism. Self‐injurious behaviors (SIBs) also occur in a subset of patients. This study used diffusion tensor imaging (DTI) in children with TSC for quantitative and volumetric analysis of brain regions that have been associated with SIB in other genetic conditions. METHODS We used DTI to compare 6 children with TSC‐associated SIB and 10 children with TSC without SIB. Atlas‐based analysis of DTI data and calculation of number of voxels; fractional anisotropy (FA); and mean, axial, and radial diffusivity were performed for multiple regions; DTI measures were summarized using medians and interquartile ranges and were compared using Wilcoxon rank sum tests and false discovery rates (FDRs). RESULTS Analysis showed that children with TSC and SIB had reduced numbers of voxels (median) in the bilateral globus pallidus (right: 218 vs. 260, P = .008, FDR = .18; left: 222 vs. 274, P = .002, FDR = .12) and caudate nucleus (right: 712 vs. 896, P = .01, FDR = .26; left: 702 vs. 921, P = .03, FDR = .44) and reduced FA in the bilateral globus pallidus (right: .233 vs. .272, P = .003, FDR = .12; left: .223 vs. .247, P = .004, FDR = .12) and left caudate nucleus (.162 vs. .186, P = .03, FDR = .39) versus children without SIB. No other statistically significant differences were found. CONCLUSIONS These data support a correlation between lower volumes of the globus pallidus and caudate with SIB in children with TSC.

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Section: Discussionmentioning

confidence: 99%

Characterization of the Basal Ganglia Using Diffusion Tensor Imaging in Children with Self‐Injurious Behavior and Tuberous Sclerosis Complex

Gipson

Poretti

Kelley

et al. 2019

Journal of Neuroimaging

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“…And the retention of cerebrospinal fluid (CSF) at the injury site may increase the diffusion degree of water molecules, resulting in the increase of MD value. There are also some studies on acute SCI that indicate a transient decrease in MD value postinjury [ 5 , 46 ], which may be the result of cell swelling, as it can cause an increase in cell radius, leading to an increased tortuosity, and ultimately induce a decrease in MD value [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of $b$ Value on Imaging Quality for Diffusion Tensor Imaging of the Spinal Cord at Ultrahigh Field Strength

Bao

Zhao

Bao

et al. 2021

BioMed Research International

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Objective. To explore the optimal b value setting for diffusion tensor imaging of rats’ spinal cord at ultrahigh field strength (7 T). Methods. Spinal cord diffusion tensor imaging data were collected from 14 rats (5 healthy, 9 spinal cord injured) with a series of b values (200, 300, 400, 500, 600, 700, 800, 900, and 1000 s/mm2) under the condition that other scanning parameters were consistent. The image quality (including image signal-to-noise ratio and image distortion degree) and data quality (i.e., the stability and consistency of the DTI-derived parameters, referred to as data stability and data consistency) were quantitatively evaluated. The min-max normalization method was used to process the calculation results of the four indicators. Finally, the image and data quality under each b value were synthesized to determine the optimal b value. Results. b = 200 s / m m 2 and b = 900 s / m m 2 ranked in the top two of the comprehensive evaluation, with the best image quality at b = 200 s / m m 2 and the best data quality at b = 900 s / m m 2 . Conclusion. Considering the shortcomings of the ability of low b values to reflect the microstructure, b = 900 s / m m 2 can be used as the optimal b value for 7 T spinal cord diffusion tensor scanning.

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“…The software measured the intensity of the brown color—a HRP reaction product. In order to enhance the accuracy of quantification, only the percentage of “high positive” staining intensity was measured [ 43 ].…”

Section: Methodsmentioning

confidence: 99%

Silencing VDAC1 to Treat Mesothelioma Cancer: Tumor Reprograming and Altering Tumor Hallmarks

et al. 2022

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Mesothelioma, an aggressive cancer with a poor prognosis, is linked to asbestos exposure. However, carbon nanotubes found in materials we are exposed to daily can cause mesothelioma cancer. Cancer cells reprogram their metabolism to support increased biosynthetic and energy demands required for their growth and motility. Here, we examined the effects of silencing the expression of the voltage-dependent anion channel 1 (VDAC1), controlling the metabolic and energetic crosstalk between mitochondria and the rest of the cell. We demonstrate that VDAC1 is overexpressed in mesothelioma patients; its levels increase with disease stage and are associated with low survival rates. Silencing VDAC1 expression using a specific siRNA identifying both mouse and human VDAC1 (si-m/hVDAC1-B) inhibits cell proliferation of mesothelioma cancer cells. Treatment of xenografts of human-derived H226 cells or mouse-derived AB1 cells with si-m/hVDAC1-B inhibited tumor growth and caused metabolism reprogramming, as reflected in the decreased expression of metabolism-related proteins, including glycolytic and tricarboxylic acid (-)cycle enzymes and the ATP-synthesizing enzyme. In addition, tumors depleted of VDAC1 showed altered microenvironments and inflammation, both associated with cancer progression. Finally, tumor VDAC1 silencing also eliminated cancer stem cells and induced cell differentiation to normal-like cells. The results show that silencing VDAC1 expression leads to reprogrammed metabolism and to multiple effects from tumor growth inhibition to modulation of the tumor microenvironment and inflammation, inducing differentiation of malignant cells. Thus, silencing VDAC1 is a potential therapeutic approach to treating mesothelioma.

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Degeneration of white matter and gray matter revealed by diffusion tensor imaging and pathological mechanism after spinal cord injury in canine

Abstract: Diffusion tensor imaging is more sensitive to degeneration of white matter than gray matter, and the white matter degeneration may be not symmetrical which meant the caudal degradation appeared to be more severe than the rostral one.

Cited by 11 publications

References 39 publications

Characterization of the Basal Ganglia Using Diffusion Tensor Imaging in Children with Self‐Injurious Behavior and Tuberous Sclerosis Complex

Characterization of the Basal Ganglia Using Diffusion Tensor Imaging in Children with Self‐Injurious Behavior and Tuberous Sclerosis Complex

Effect of $b$ Value on Imaging Quality for Diffusion Tensor Imaging of the Spinal Cord at Ultrahigh Field Strength

Silencing VDAC1 to Treat Mesothelioma Cancer: Tumor Reprograming and Altering Tumor Hallmarks

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Degeneration of white matter and gray matter revealed by diffusion tensor imaging and pathological mechanism after spinal cord injury in canine

Abstract: Diffusion tensor imaging is more sensitive to degeneration of white matter than gray matter, and the white matter degeneration may be not symmetrical which meant the caudal degradation appeared to be more severe than the rostral one.

Cited by 11 publications

References 39 publications

Characterization of the Basal Ganglia Using Diffusion Tensor Imaging in Children with Self‐Injurious Behavior and Tuberous Sclerosis Complex

Characterization of the Basal Ganglia Using Diffusion Tensor Imaging in Children with Self‐Injurious Behavior and Tuberous Sclerosis Complex

Effect of b Value on Imaging Quality for Diffusion Tensor Imaging of the Spinal Cord at Ultrahigh Field Strength

Silencing VDAC1 to Treat Mesothelioma Cancer: Tumor Reprograming and Altering Tumor Hallmarks

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Effect of $b$ Value on Imaging Quality for Diffusion Tensor Imaging of the Spinal Cord at Ultrahigh Field Strength