Degeneration of newly formed CA1 neurons following global ischemia in the rat

Bueters, Tjerk; Euler, Mia von; Bendel, Olof; Euler, Gabriel von

doi:10.1016/j.expneurol.2007.09.005

Cited by 49 publications

(39 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies have documented progressive neuronal degeneration in the hippocampus following brief periods of ischemia or trauma (Smith et al 1997;Bendel et al 2005;Bueters et al 2008;Kiryk et al 2011). Notably, Bueters et al (2008) found that an accumulation of large calcium deposits occurred in the late neurodegeneration phase, affecting newly generated CA1 neurons, but not at early time points (2-14 days after ischemia) despite extensive neuronal cell death. The results suggest that these calcification processes may be associated with neuroinflammatory and astroglial reactions.…”

Section: Discussionmentioning

confidence: 99%

“…Given that calcium precipitation in the ischemic brain is associated with impaired calcium homeostasis and neurodegeneration (Gutierrez-Diaz et al 1985;Dux et al 1987;Bonnekoh et al 1992;Shirotani et al 1994;Ohta et al 1996;Watanabe et al 1998;Puka-Sundvall et al 2000;Bueters et al 2008) and that neuronal death was restricted mainly to the hippocampal CA1 region after a four-vessel occlusion insult of the same period (Pulsinelli et al 1982), progressive calcium deposition in the ischemic hippocampal CA1 regions may be due to long-lasting degenerative processes occurring in these regions. Several studies have documented progressive neuronal degeneration in the hippocampus following brief periods of ischemia or trauma (Smith et al 1997;Bendel et al 2005;Bueters et al 2008;Kiryk et al 2011).…”

Section: Discussionmentioning

confidence: 99%

“…Oliveira et al 2003;Bueters et al 2008). Several lines of evidence suggest that OPN plays a major role in the regulation of ectopic calcification and pathological mineralization of the vasculature (Steitz et al 2002;Fujita et al 2003;Makiishi-Shimobayashi et al 2004;Pampena et al 2004;Giachelli 2005;Scatena et al 2007).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Sustained Expression of Osteopontin Is Closely Associated with Calcium Deposits in the Rat Hippocampus After Transient Forebrain Ischemia

Park

Shin

Kim

et al. 2012

J Histochem Cytochem.

View full text Add to dashboard Cite

The present study was designed to evaluate the extent and topography of osteopontin (OPN) protein expression in the rat hippocampus 4 to 12 weeks following transient forebrain ischemia, and to compare OPN expression patterns with those of calcium deposits and astroglial and microglial reactions. Two patterns of OPN staining were recognized by light microscopy: 1) a diffuse pattern of tiny granular deposits throughout the CA1 region at 4 weeks after ischemia and 2) non-diffuse ovoid to round deposits, which formed conglomerates in the CA1 pyramidal cell layer over the chronic interval of 8 to 12 weeks. Immunogold-silver electron microscopy and electron probe microanalysis demonstrated that OPN deposits were indeed diverse types of calcium deposits, which were clearly delineated by profuse silver grains indicative of OPN expression. Intracellular OPN deposits were frequently observed within reactive astrocytes and neurons 4 weeks after ischemia but rarely at later times. By contrast, extracellular OPN deposits progressively increased in size and appeared to be gradually phagocytized by microglia or brain macrophages and some astrocytes over 8 to 12 weeks. These data indicate an interaction between OPN and calcium in the hippocampus in the chronic period after ischemia, suggesting that OPN binding to calcium deposits may be involved in scavenging mechanisms.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Sustained Expression of Osteopontin Is Closely Associated with Calcium Deposits in the Rat Hippocampus After Transient Forebrain Ischemia

Park

Shin

Kim

et al. 2012

J Histochem Cytochem.

View full text Add to dashboard Cite

show abstract

“…[27][28][29] Beginning on day 21, the animals were subjected to two tests per day for about five days. The test duration was 30 min every day.…”

Section: Morris Water Mazementioning

confidence: 99%

Original Research: The expression of MMP2 and MMP9 in the hippocampus and cerebral cortex of newborn mice under maternal lead exposure

et al. 2016

Exp Biol Med (Maywood)

View full text Add to dashboard Cite

The current study focused on the MMP2 and MMP9 expression in cerebral cortex and hippocampus of newborn mice under maternal lead exposure. Lead exposure was initiated from gestation to weaning. Lead acetate was dissolved in deionized water with concentration of 0.1, 0.2, and 0.5% and was absorbed through daily drinking. On day 21 after birth, lead in blood and tissue levels was examined by Graphite Furnace Atomic Absorption Spectrum (GFAAS). The protein expressions of MMP2 and MMP9 in hippocampus and cerebral cortex tissues were tested by western blotting and immunohistochemistry. Compared to the control group, blood, cerebral cortex, and hippocampus lead levels of newborn mice in 0.1, 0.2, and 0.5% lead exposure groups were markedly high (P < 0.05), and mice within the 0.2 and 0.5% lead exposure groups performed much worse than that of the control group in Water Maze test (P < 0.05). Compared with the control group, MMP2 and MMP9 expressions in hippocampus were upregulated in the lead exposure groups (P < 0.05), and the MMP2 and MMP9 expressions in cerebral cortex were also higher (P < 0.05). The increased expression of MMP2 and MMP9 in the hippocampus and cerebral cortex may lead to the neurotoxicity in the context of maternal lead exposure.

show abstract

“…Spatial learning and memory was not affected compared to control animals, except for a less efficient search strategy in the Morris water maze test [29]. Therefore it seems possible that the number of newly generated neurons after 28 days may be further reduced after a longer period of survival.…”

Section: Discussionmentioning

confidence: 97%