Degeneration of megaesophagus. Is there a particular symptomatology?

Ellis, F. Henry; Endo, Masatsugu

doi:10.1007/978-3-642-73055-9_183

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2006

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“…The development of squamous cell carcinoma as a complication of achalasia has been reported to have an incidence of 1-20% with Different etiologies of achalasia I Gockel et al a risk increased 33-fold over the general population. [25][26][27] Precancerous lesions in achalasia often develop as a consequence of chronic inflammatory reactions of the squamous epithelium of the esophagus. 28 Probably a gradual process with progression from squamous cell hyperplasia (as seen in 6/8 compete resections in the present patients with end-stage achalasia) to dysplasia and finally to a carcinoma, similar to the sporadic squamous cell carcinoma, is evident.…”

Section: Discussionmentioning

confidence: 99%

Spectrum of histopathologic findings in patients with achalasia reflects different etiologies

Gockel¹,

Bohl

Doostkam

et al. 2006

J of Gastro and Hepatol

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The histopathological investigations of the esophageal wall in 17 patients undergoing esophageal resection or myotomy for achalasia suggest that the reduction of intramural ganglion cells might be a secondary change, probably due to inflammation triggered by autoimmune mechanisms or a chronic degenerative process of the central and/or peripheral part of the vagal nerve. The primary lesion could also be a severe myopathy of the smooth muscle cells.

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Section: Discussionmentioning

confidence: 99%