Degeneration and Ossification of the Yellow Ligament in Unstable Spine

Nakamura, Takafumi; Hashimoto, Noburo; Maeda, Yukihide; Ikeda, Takashi; Nakagawa, Hiroaki; Takagi, Katsumasa

doi:10.1097/00024720-199012000-00002

Cited by 10 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pronounced hypertrophy of both the sesamoid and enthesis fibrocartilages, reflecting increased mechanical stressing, in the dorsal capsule of the apophyseal joints has been noted in patients with degenerative instability of the spine (25). The link between mechanical load, fibrocartilage hypertrophy, and ossification may have parallels with changes that occur in the numerous other spinal ligaments involved in SpA (26). Therefore, findings in the limited studies of the entheses involved in SpA support the concept that these are common sites of tissue microtrauma.…”

Section: Pathology and Microtrauma At Insertionsmentioning

confidence: 90%

Report on the Second International Enthesitis Workshop

McGonagle¹,

Marzo‐Ortega²,

Benjamin³

et al. 2003

Arthritis & Rheumatism

105

View full text Add to dashboard Cite

Section: Pathology and Microtrauma At Insertionsmentioning

confidence: 90%

Report on the Second International Enthesitis Workshop

McGonagle¹,

Marzo‐Ortega²,

Benjamin³

et al. 2003

Arthritis & Rheumatism

105

View full text Add to dashboard Cite

“…14,16,17,30 -32 In regard to the association with image findings, there are some reports on the possible association with ossification or regressive change due to instability. 33 Many of these reports discussed pathologic findings that were likely to attract attention, such as degeneration of elastic fibers, calcification, and ossification. Therefore, details of the clinical significance of other various focal lesions have not been elucidated.…”

mentioning

confidence: 99%

The Pathology of Ligamentum Flavum in Degenerative Lumbar Disease

Okuda

Baba²,

Fujimoto³

et al. 2004

Spine

106

View full text Add to dashboard Cite

Various pathologic findings provided important foundations for discussing the pathogenesis of lesions in ligamentum flavum. Calcification was frequently observed in elderly patients and those with cauda equina symptoms, and these patients tended to have severer preoperative symptoms. Chondroid cells were frequently observed in patients with spondylolisthesis, and patients with ossification had a greater % slip, suggesting involvement of mechanical load in ossification of ligaments. The pathologic findings were significantly related to the clinical features, and these findings will be profitable for understanding the pathogenesis of degenerative lumbar disease.

show abstract

“…Yahia et al [28] described the presence of fibrocartilage within the ligament using SEM. Furthermore, marked chondrometaplasia within the ligamentum flavum was also noted in the area of mechanical instability and calcified deposits [10,13,17], although another study failed to find the same changes [19]. We suggest that TGF-bs may play an important role in the chondrometaplasia of degenerative fibrous tissue in the early stages of calcification of ligamentum flavum.…”

Section: Discussionmentioning

confidence: 64%

Calcium Crystal Deposition in the Ligamentum Flavum of the Lumbar Spine: Role of Sex Hormones and Transforming Growth Factor-.BETA.

Yayama

Furusawa

Baba

et al. 2003

Acta Histochem. Cytochem

View full text Add to dashboard Cite

We investigated histopathological and immunohistochemical properties of the ligamentum flavum of the lumbar spine with calcium crystal deposition. Ligamentum flavum of the lumbar spine containing calcium deposits were harvested from 41 surgical cases. Sections of the ligaments were immunostained for estrogen receptor (ER), progesterone receptor (PR), and transforming growth factor (TGF)-b. The results were compared with those of ligaments without calcium deposits. The elastic fibers of the ligament with calcium deposits showed marked degeneration (irregular arrangement and fragmentation of fiber bundles) and nodular lesions. Deposits of calcium crystals were present in these areas where elastic fibers were degenerated. Immunostaining for ER was positive in these areas, and PR as well as TGF-b-containing chondrocytes were detected around and within the calcified areas. TGF-b, ER and PR-containing chondrocytes appeared to precipitate deposition of calcium crystals in the nodular lesions of the degenerated lumbar ligamentum flavum. Our results suggest that TGF-b and sex hormones play a role in the calcification of the lumbar ligamentum flavum.

show abstract

Degeneration and Ossification of the Yellow Ligament in Unstable Spine

Cited by 10 publications

References 0 publications

Report on the Second International Enthesitis Workshop

Report on the Second International Enthesitis Workshop

The Pathology of Ligamentum Flavum in Degenerative Lumbar Disease

Calcium Crystal Deposition in the Ligamentum Flavum of the Lumbar Spine: Role of Sex Hormones and Transforming Growth Factor-.BETA.

Contact Info

Product

Resources

About