Defossilization of pharmaceutical manufacturing

On the chemistry of furfuryl alcohol polymerization: A review

“…An increasing focus is exploring sustainable material sources that reduce reliance on petroleum‐based resources. This shift benefits local job stability, stimulates economic expansion, encourages technological advancements, safeguards foreign reserves, supports de‐fossilization initiatives, and aligns with the objectives of sustainable development goals (SDGs) 7–10 . The scientific consensus is growing as we reassess our dependence on polymers derived from fossil hydrocarbons with the increasing push to explore more environmentally friendly, renewable, and sustainable alternatives such as the furans (i.e., furan‐based chemicals) from plant wastes, which can provide comparable or superior properties to support sustainable development efforts 11–14 .…”

“…This shift benefits local job stability, stimulates economic expansion, encourages technological advancements, safeguards foreign reserves, supports de-fossilization initiatives, and aligns with the objectives of sustainable development goals (SDGs). [7][8][9][10] The scientific consensus is growing as we reassess our dependence on polymers derived from fossil hydrocarbons with the increasing push to explore more environmentally friendly, renewable, and sustainable alternatives such as the furans (i.e., furan-based chemicals) from plant wastes, which can provide comparable or superior properties to support sustainable development efforts. [11][12][13][14] Wastes from vegetable biomass such as corncobs and sugarcane bagasse (i.e., above-the-ground hydrocarbons) offer significant potential as a sustainable and eco-friendly alternative, with the capacity to be transformed into a diverse array of chemicals and materials that can outperform fossil hydrocarbons (i.e., below-the-ground hydrocarbons).…”

Nanoconfinement Effects of Micellar Media in Asymmetric Catalysis

“…Proper solvent selection is the first target of every process aiming at the improvement of the sustainability; in fact, over the years a series of review articles discussing different approaches for solvent picking were published, [8] favoring the real replacement of toxic solvents like chlorinated and aromatic ones with others less harmful, [9,10] especially under the impulse provided by pharmaceutical companies [11] . Green solvents [12] have been proposed over the years like ionic liquids, [13] deep eutectic solvents, [14] biobased solvents to improve defossilization, [15] some of which leading also to industrial applications. Among all, thanks to its low cost, large availability, high heat capacity and non‐flammability, water is gaining momentum as a true sustainable solvent for chemical transformations, [16] and in general as medium for organic chemistry [17] .…”

One-Pot Consecutive Reductive Amination Synthesis of Pharmaceuticals: From Biobased Glycolaldehyde to Hydroxychloroquine

“…3,4 While the higher complexity of the target molecules and the associated multiple synthesis steps combined with the stringent regulatory requirements of drug purity partially justify the substantially elevated waste burden, they also accentuate the opportunity for improvements. 3,5,6 The amine functional group is widely incorporated in the armory of today's commercially available drugs. 7 In this context, reductive amination is commonly proposed as a green path for the synthesis of the amines used as an alternative to the S N 2-type reactions with halides, which helps avoid stoichiometric amounts of waste.…”

“…During active pharmaceutical ingredient (API) manufacturing, approximately 85% of the waste is solvent-related. Thus, addressing the selection, use, recovery, and disposal of solvents contributes dramatically to alleviating this waste problem. , While the higher complexity of the target molecules and the associated multiple synthesis steps combined with the stringent regulatory requirements of drug purity partially justify the substantially elevated waste burden, they also accentuate the opportunity for improvements. ,, …”