In gas gun experiments, a graded density impactor (GDI) is used to achieve quasi-isentropic loading. However, inconsistency between the designed and experimental loading profiles, mainly caused by by-products during preparation, limits the application of GDI for a long time. In this work, a kind of W/Ti GDI with advantages of a wide density range of 4.5–19.3 g/cm3 and high structural designability was designed and synthesized. Each of mid-layers of the W/Ti GDI was composed of W and Ti without the formation of an intermetallic compound, and had good parallelism and flatness. This provides a prerequisite for good agreement between the designed and experimental loading profiles. Due to the high designability of the GDI, quasi-isentropic loading with different stress-paths was achieved by controlling the structure of the GDI. Then, independently controlling peak stress and strain rates of loading was successfully achieved by changing the flyer velocity and the type of the W/Ti GDI. The W/Ti GDI has enormous application potential in studying the dynamic response of materials under quasi-isentropic loading with stress and strain rate controlled.