Deformation and Mechanical Characteristics of Compacted Binary Mixtures of Plastic (Microcrystalline Cellulose), Elastic (Sodium Starch Glycolate), and Brittle (Lactose Monohydrate) Pharmaceutical Excipients

Al-Ibraheemi, Zahraa A Mousa; Anuar, M. S.; Taip, Farah Saleena; Amin, Mohd Cairul Iqbal Mohd; Tahir, Suraya Mohd; Mahdi, Ali Basim

doi:10.1080/02726351.2013.785451

Cited by 45 publications

(23 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…20 , 21 In addition, excellent plastic deformability and dry binding ability of MCC 22 dominantly attributed to superior mechanical strength (6.5 kp) to the F1 compared to the F2 and F3 formulas ( Figure 1B ). In consistent with our results, Al-Ibraheemia et al 23 reported that MCC provided better physical properties over sodium starch glycolate (elastic deformation material) or lactose (brittle material) during the compaction process of coated particles. Therefore, MCC was chosen for further preparation of ECPs-T formulae.…”

Section: Resultssupporting

confidence: 93%

Multiple-unit tablet of probiotic bacteria for improved storage stability, acid tolerability, and in vivo intestinal protective effect

Park

Lee

Jun

et al. 2016

DDDT

View full text Add to dashboard Cite

The aim of this study was to formulate probiotics-loaded pellets in a tablet form to improve storage stability, acid tolerability, and in vivo intestinal protective effect. Bacteria-loaded pellets primarily prepared with hydroxypropyl methylcellulose acetate succinate were compressed into tablets with highly compressible excipients and optimized for flow properties, hardness, and disintegration time. The optimized probiotic tablet consisted of enteric-coated pellets (335 mg), microcrystalline cellulose (Avicel PH102, 37.5 mg), and porous calcium silicate (25 mg) and allowed whole survival of living bacteria during the compaction process with sufficient tablet hardness (13 kp) and disintegration time (14 minutes). The multiple-unit tablet showed remarkably higher storage stability under ambient conditions (25°C/60% relative humidity) over 6 months and resistance to acidic medium compared to uncoated strains or pellets. Repeated intake of this multiple-unit tablet significantly lowered plasma level of endotoxin, a pathogenic material, compared to repeated intake of bare probiotics or marketed products in rats. These results, therefore, suggest that the multiple-unit tablet is advantageous to better bacterial viability and gain the beneficial effects on the gut flora, including the improvement of intestinal barrier function.

show abstract

Section: Resultssupporting

confidence: 93%

Multiple-unit tablet of probiotic bacteria for improved storage stability, acid tolerability, and in vivo intestinal protective effect

Park

Lee

Jun

et al. 2016

DDDT

View full text Add to dashboard Cite

show abstract

“…The MCC:LAC ratio was varied at three levels (3:2, 1:1, and 2:3), which modified the net deformation behavior of the formulation from predominantly plastic to brittle. This has been demonstrated in previous work by Mousa Al-Ibraheemi et al., 28 where an increase in MCC proportion in a MCC/LAC mixture led to statistically significant increase in plastic energy. 28 The concentrations of glidant and lubricant were modified at three levels (low, medium, and high).…”

Section: Methodssupporting

confidence: 76%

“…This has been demonstrated in previous work by Mousa Al-Ibraheemi et al, 28 where an increase in MCC proportion in a MCC/LAC mixture led to statistically significant increase in plastic energy. 28 The concentrations of glidant and lubricant were modified at three levels (low, medium, and high). The levels of glidant/ lubricant are typically varied to compensate for the physical effect of API on flow behavior.…”

Section: Methods Developmentsupporting

confidence: 76%

Understanding the Impact of Chemical Variability and Calibration Algorithms on Prediction of Solid Fraction of Roller Compacted Ribbons Using Near-Infrared (NIR) Spectroscopy

et al. 2016

View full text Add to dashboard Cite

The study is aimed at developing a near-infrared (NIR) method for predicting solid fraction (SF) of dry granulated ribbons manufactured with formulation variability. The study investigated the impact of unmodeled chemical variability and regression approaches on method performance. The study utilized an excipient-only formulation system. Calibration compacts were created with chemical and processing variability; followed by collection of NIR spectra. Partial least squares (PLS) and spectral slope algorithms were utilized to model compact SF. Later, the models were deployed to predict SF of test ribbons and compacts containing an API at various concentrations. The risk associated with unmodeled chemical variation manifested itself through generation of new peaks and decreased baseline absorbance in the NIR spectra. The spectral slope was able to better manage this risk, as demonstrated by relatively higher robustness to the increasing load of the active pharmaceutical ingredient (API). The reduced robustness of the PLS approach was attributed to the impact of chemical variability on both spectral baseline and peak absorbance. A prediction error of approximately 5% was observed at 10% drug load using the spectral slope approach. An understanding of the risk associated with unmodeled variability will enable NIR method development as an API sparing technique for low-dose product development.

show abstract

“…The values of plastic work obtained for all formulation were found to be statistically signi icant (P<0.05). In a previous work done by Al-Ibraheemi et al (2013), the combination of MCC/Lac and SSG/Lac tablet also show that the tablets exhibit lower plastic work at a high percentage of lactose. The high value of plastic work experienced by DP tablets is due to the extensive plastic deformation of the particles during the loading stage showing that DP particles are highly ductile.…”

Section: Plastic Workmentioning

confidence: 72%

Compaction behaviour and mechanical characteristics of chewable binary tablet mixture containing lactose (Flowlac 100) and date (Phoenix dactylifera) powders

Hamidi

Anuar

Baharuddin

et al. 2019

ijrps

View full text Add to dashboard Cite

This study aimed to develop a formulation for a chewable tablet using date powder (DP) and Flowlac 100 utilizing a direct compression method. The powders were compacted as single and binary mixtures at five different formulations (DPL1, DPL2, DPL3, DPL4 and DPL5) to study their compaction behaviour. Stressor ranging from 15 to 74 MPa in a cylindrical die with flat face punches were introduced during the fabrication process, and the mechanical properties (plastic work, flexible work and tensile strength) of formed tablets were investigated. Findings of this study demonstrated that with a high percentage of DP in the formulation resulted in a high reading of plastic work, while a low amount of DP revealed low elastic work. Tensile strength of the tablet, on the other hand, varies with the percentage of DP present and applied pressure used. Formulation with 60% DP (DPL4) displayed the highest tensile strength compared to the other formulations, and it is coherent with industrial preferable tensile strength limit. In conclusion, the current findings could be useful in formulation and fabricating date chewable tablet which can be used as a food supplement by all categories of consumers since it is easy to be consumed by a wide range of age.

show abstract

Deformation and Mechanical Characteristics of Compacted Binary Mixtures of Plastic (Microcrystalline Cellulose), Elastic (Sodium Starch Glycolate), and Brittle (Lactose Monohydrate) Pharmaceutical Excipients

Cited by 45 publications

References 14 publications

Multiple-unit tablet of probiotic bacteria for improved storage stability, acid tolerability, and in vivo intestinal protective effect

Multiple-unit tablet of probiotic bacteria for improved storage stability, acid tolerability, and in vivo intestinal protective effect

Understanding the Impact of Chemical Variability and Calibration Algorithms on Prediction of Solid Fraction of Roller Compacted Ribbons Using Near-Infrared (NIR) Spectroscopy

Compaction behaviour and mechanical characteristics of chewable binary tablet mixture containing lactose (Flowlac 100) and date (Phoenix dactylifera) powders

Contact Info

Product

Resources

About