Deformation and fatigue of tough 3D printed elastomer scaffolds processed by fused deposition modeling and continuous liquid interface production

Miller, Andrew T.; Safranski, David L.; Wood, Catherine L.; Guldberg, Robert E.; Gall, Ken

doi:10.1016/j.jmbbm.2017.06.038

Cited by 35 publications

(23 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 11 In addition, in the field of lithographic printing of bioinks, the development of fast printing approaches with higher lateral resolution has been demonstrated via the continuous liquid interface production printing. 277 This variation of DLP and SLA technology takes advantage of the use of inks based on acryloyl chemistry, in which chain polymerization reaction can be inhibited by the presence of oxygen species. Introducing an oxygen permeable membrane between the vat and the optical window used for irradiating the resin permits avoiding cross-linking at the bottom of the material reservoir, and therefore detaching the printed part rapidly, with minimal forces, enabling a much rapid, nearly continuous printing process.…”

Section: Implications For Lithography-based Printing Technologiesmentioning

confidence: 99%

“… 278 With such an approach, the integration between consecutive layers is facilitated, giving rise to structure with superior mechanical stability compared to conventional layer-by-layer additive manufacturing. 277 While oxygen inhibition can be the cause for inadequate cross-linking and hampering shape fidelity, spatially controlled presence of oxygen species within a printed geometry have been purposely used to create hydrogel structures with local differences in mechanical stiffness. For instance, PEG dimethacrylate constructs with vertically oriented pillars, displaying different elastic modulus were printed, creating gels that can bend easily in the areas laden with soft pillars, which can have application as hydrogel-based actuators.…”

Section: Implications For Lithography-based Printing Technologiesmentioning

confidence: 99%

See 1 more Smart Citation

Printability and Shape Fidelity of Bioinks in 3D Bioprinting

et al. 2020

View full text Add to dashboard Cite

Three-dimensional bioprinting uses additive manufacturing techniques for the automated fabrication of hierarchically organized living constructs. The building blocks are often hydrogel-based bioinks, which need to be printed into structures with high shape fidelity to the intended computer-aided design. For optimal cell performance, relatively soft and printable inks are preferred, although these undergo significant deformation during the printing process, which may impair shape fidelity. While the concept of good or poor printability seems rather intuitive, its quantitative definition lacks consensus and depends on multiple rheological and chemical parameters of the ink. This review discusses qualitative and quantitative methodologies to evaluate printability of bioinks for extrusion- and lithography-based bioprinting. The physicochemical parameters influencing shape fidelity are discussed, together with their importance in establishing new models, predictive tools and printing methods that are deemed instrumental for the design of next-generation bioinks, and for reproducible comparison of their structural performance.

show abstract

Section: Implications For Lithography-based Printing Technologiesmentioning

confidence: 99%

Section: Implications For Lithography-based Printing Technologiesmentioning

confidence: 99%

Printability and Shape Fidelity of Bioinks in 3D Bioprinting

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Nevertheless, a conflict arises when considering this hybrid system, as increasing the proportion of void space in the construct comes at the cost of diminished mechanical properties. Increasing the porosity of PCU, while not impacting tensile failure strain, decreases the tensile failure stress and stiffness of the structure (Miller, Safranski, Wood, Guldberg, & Gall, 2017). Conversely, decreasing the porosity can limit both mass transport and the ingrowth of tissue.…”

Section: Introductionmentioning

confidence: 99%

3D printing of high‐strength, porous, elastomeric structures to promote tissue integration of implants

Abar

Alonso‐Calleja

Kelly

et al. 2020

J Biomedical Materials Res

Self Cite

View full text Add to dashboard Cite

Despite advances in biomaterials research, there is no ideal device for replacing weight-bearing soft tissues like menisci or intervertebral discs due to poor integration with tissues and mechanical property mismatch. Designing an implant with a soft and porous tissue-contacting structure using a material conducive to cell attachment and growth could potentially address these limitations. Polycarbonate urethane (PCU) is a soft and tough biocompatible material that can be 3D printed into porous structures with controlled pore sizes. Porous biomaterials of appropriate chemistries can support cell proliferation and tissue ingrowth, but their optimal design parameters remain unclear. To investigate this, porous PCU structures were 3D-printed in a crosshatch pattern with a range of in-plane pore sizes (0 to 800 μm) forming fully interconnected porous networks. Printed porous structures had ultimate tensile strengths ranging from 1.9 to 11.6 MPa, strains to failure ranging from 300 to 486%, Young's moduli ranging from 0.85 to 12.42 MPa, and porosity ranging from 13 to 71%. These porous networks can be loaded with hydrogels, such as collagen gels, to provide additional biological support for cells. Bare PCU structures and collagenhydrogel-filled porous PCU support robust NIH/3T3 fibroblast cell line proliferation over 14 days for all pore sizes. Results highlight PCU's potential in the development of tissue-integrating medical implants.

show abstract

“…Moreover, EPU-based polymers have gained popularity as compliant implant materials in the arena of biomedical engineering [57]. The AM provides new and ever-expanding applications in bio-sciences where it helps to create more complex architectures for tissue scaffolding and patient specific implants using light-cured based techniques [35]. Very recently, Miller et al [35] quantify the effects of various printing factors on the mechanical behaviour of elastomeric EPUs (EPU40 and EPU41 of Carbon3D).…”

Section: Introductionmentioning

confidence: 99%

3D printed elastomeric polyurethane: Viscoelastic experimental characterizations and constitutive modelling with nonlinear viscosity functions

Hossain

Navaratne

Perić

2020

International Journal of Non-Linear Mechanics

View full text Add to dashboard Cite

Digital Light Synthesis (DLS) technology creates ample opportunities for making 3D printed soft polymers for a wide range of grades and properties. In DLS, a 3D printer uses a continuous building technique in which the curing process is activated by an ultraviolet (UV) light. In this contribution, EUP40, a recently invented commercially available elastomeric polyurethane (EPU) printed by the DLS technology, is experimentally characterised. For characterizing the mechanical properties, an extensive viscoelastic experimental study on the digitally printed EPU taking the strain rate-dependence are conducted. The study reveals a significant time-dependency on its mechanical responses. Moreover, the material demonstrates noticeable nonlinear viscosities that depend on strain and strain rates. Based on the experimental findings for the printed elastomer, a large strain viscoelastic model is devised where evolution laws are enhanced by strain and strain rate-dependent nonlinear viscosities. Following identifications of relevant material parameters, we validate the model with the experimental data that show its good predictability. Such an extensive experimental study along with a constitutive model will help in designing and simulating more complex cellular and structured metamaterials using 3D printed elastomeric polyurethanes.

show abstract

Deformation and fatigue of tough 3D printed elastomer scaffolds processed by fused deposition modeling and continuous liquid interface production

Cited by 35 publications

References 45 publications

Printability and Shape Fidelity of Bioinks in 3D Bioprinting

Printability and Shape Fidelity of Bioinks in 3D Bioprinting

3D printing of high‐strength, porous, elastomeric structures to promote tissue integration of implants

3D printed elastomeric polyurethane: Viscoelastic experimental characterizations and constitutive modelling with nonlinear viscosity functions

Contact Info

Product

Resources

About