Deformation Analysis of Myocardial Layers Detects Early Cardiac Dysfunction after Chemotherapy in Bone Marrow Transplantation Patients: A Continuous and Additive Cardiotoxicity Process

Paraskevaidis, Ioannis; Makavos, George; Tsirigotis, Panagiotis; Psarogiannakopoulos, Panagiotis; Parissis, John; Gkirkas, Konstantinos; Pessach, Ilias; Ikonomidis, Ignatios

doi:10.1016/j.echo.2017.07.010

Cited by 24 publications

(14 citation statements)

References 39 publications

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“…Paraskevaidis, et al demonstrated that GLS, especially the subendocardial longitudinal strain, was impaired at 1 month after bone marrow transplantation (BMT), and that a cutoff GLS of −18.4% at 1 month after BMT showed high sensitivity and specificity for the identification of abnormal LVEF at 12 months post-BMT. 21) At 6 months after HSCT, the cutoff LVEF value of 55% clearly indicated GLS less than −18.5%, which was coincidentally the same as in a previous report (Figure 4B). Although the low EF group was not divided at the pre-HSCT stage (Figure 4A), 3 (50.0%) and 5 (83.3%) patients in the low EF group showed GLS < −18.5% at baseline and 1 month post-HSCT, respectively.…”

Section: Discussionsupporting

confidence: 88%

Serial Changes in Cardiac Strain and Contractility After Hematopoietic Stem Cell Transplantation in Patients with Hematologic Malignancies

et al. 2021

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Hematopoietic stem cell transplantation (HSCT) is occasionally associated with cardiac dysfunction during long-term follow-up. Global longitudinal strain (GLS) has emerged as an early predictor of cardiotoxicity associated with cancer therapy; however, the serial changes in GLS before and after HSCT have not been elucidated. To clarify the association between HSCT and GLS, we investigated serial changes in GLS before and after HSCT. We evaluated cardiac function before and 1, 3, and 6 months after HSCT in 38 consecutive HSCT patients enrolled in this study. Overall, GLS and left ventricular (LV) ejection fraction (EF) temporally decreased 1 month post-HSCT. LVEF completely recovered to baseline at 3 months after HSCT, whereas GLS partially recovered 6 months after HSCT. Except for five patients who died within 6 months, GLS values in the low EF group (LVEF !55% at 6 months post-HSCT, n = 6) were significantly and consistently lower than those in the normal EF group (LVEF > 55% at 6 months post-HSCT, n = 27) at any time during follow-up. These findings suggest that GLS before HSCT might be associated with a decrease in LVEF after HSCT in patients with hematologic malignancies. Further prospective and long-term data will be important for understanding the management of HSCT-associated cardiac dysfunction.

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Section: Discussionsupporting

confidence: 88%

Serial Changes in Cardiac Strain and Contractility After Hematopoietic Stem Cell Transplantation in Patients with Hematologic Malignancies

et al. 2021

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“…Several studies on GLS in allogeneic HSCT recipients have been reported [ 14 , 15 ]; however, much remains to be elucidated regarding long‐term cardiac follow‐up with GLS. Recent studies have shown that GLS is a more sensitive parameter than EF for evaluating cardiac function in patients with heart failure or CTRCD [ 6 , 7 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

Global longitudinal strain is superior to ejection fraction for long‐term follow‐up after allogeneic hematopoietic stem cell transplantation

Watanabe

Yakushijin

Tanaka

et al. 2022

eJHaem

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Global longitudinal strain (GLS), a new cardiac parameter measured by the speckletracking method, is reportedly more sensitive than ejection fraction (EF) in detecting slight cardiac dysfunction in heart failure patients. We validated the utility of GLS in allogeneic hematopoietic stem cell transplantation (HSCT) patients during a long-term follow-up. Medical records of patients who underwent allogeneic HSCT between 2013 and 2020 were reviewed retrospectively. We evaluated the last echocardiography performed before transplantation and those performed annually during the 5 years after transplantation. We also investigated newly diagnosed cardiac events, which developed after HSCT. Among 85 patients, 22 used cardioprotective drugs. The median follow-up duration in surviving patients was 54.1 months (range, 2.9-92.6 months).GLS significantly decreased year by year, and patients taking cardioprotective agents tended to have a better GLS at 5 years than at 3 years, while EF did not change. Fifteen patients developed newly diagnosed cardiac events. Multivariate analysis revealed that low GLS and high serum ferritin levels at baseline were independently associated with the development of cardiac events. Therefore, we need a continuous followup of cardiac function by GLS and prescription of cardioprotective drugs might be considered for HSCT patients with low GLS. Further research is warranted.

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“…Diastolic dysfunction may precede and predict late systolic dysfunction; however, no parameter of diastolic function has definitively shown to be predictive of CTX, and the studies are conflicting. 13 - 17…”

Section: Methodsmentioning

confidence: 99%

Early Detection and Monitoring of Cancer Chemotherapy-Related Left Ventricular Dysfunction by Imaging Methods

Ribeiro¹,

Jorge²,

Nacif³

et al. 2019

Arquivos Brasileiros De Cardiologia

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Deformation Analysis of Myocardial Layers Detects Early Cardiac Dysfunction after Chemotherapy in Bone Marrow Transplantation Patients: A Continuous and Additive Cardiotoxicity Process

Cited by 24 publications

References 39 publications

Serial Changes in Cardiac Strain and Contractility After Hematopoietic Stem Cell Transplantation in Patients with Hematologic Malignancies

Serial Changes in Cardiac Strain and Contractility After Hematopoietic Stem Cell Transplantation in Patients with Hematologic Malignancies

Global longitudinal strain is superior to ejection fraction for long‐term follow‐up after allogeneic hematopoietic stem cell transplantation

Early Detection and Monitoring of Cancer Chemotherapy-Related Left Ventricular Dysfunction by Imaging Methods

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