Deforestation-driven food-web collapse linked to emerging tropical infectious disease,
            <i>Mycobacterium ulcerans</i>

Morris, Aaron L.; Guégan, Jean‐François; Andreou, Demetra; Marsollier, Laurent; Carolan, Kevin; Croller, Marie Le; Sanhueza, Daniel; Gozlan, Rodolphe E.

doi:10.1126/sciadv.1600387

Cited by 54 publications

(41 citation statements)

References 42 publications

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“…For example, increases in primate crop-raiding frequency following land conversion increases E. coli transmission between humans and primates . Loss of important host predators has been highlighted as driving an increased risk of Mycobacterium ulcerans, the causative agent of Buruli ulcer, at intermediate levels of deforestation (Morris et al 2016). These additional mechanisms were not incorporated into the models but could be extensions of the framework outlined here.…”

Section: Discussionmentioning

confidence: 99%

Pathogen spillover during land conversion

et al. 2018

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Pathogen spillover from wildlife to domestic animals and humans, and the reverse, has caused significant epidemics and pandemics worldwide. Although pathogen emergence has been linked to anthropogenic land conversion, a general framework to disentangle underlying processes is lacking. We develop a multi-host model for pathogen transmission between species inhabiting intact and converted habitat. Interspecies contacts and host populations vary with the proportion of land converted; enabling us to quantify infection risk across a changing landscape. In a range of scenarios, the highest spillover risk occurs at intermediate levels of habitat loss, whereas the largest, but rarest, epidemics occur at extremes of land conversion. This framework provides insights into the mechanisms driving disease emergence and spillover during land conversion. The finding that the risk of spillover is highest at intermediate levels of habitat loss provides important guidance for conservation and public health policy.

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Section: Discussionmentioning

confidence: 99%

Pathogen spillover during land conversion

et al. 2018

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“…Buruli ulcer has also been encountered in aquatic invertebrates, mosquitoes (13, 16, 19, 91, 107, 113, 139, 141, 149, 150, 152-154, 156, 193), crayfish (108), amoeba, mollusks, crustaceans, annelida (29,40,141,153), aerosols, water, biofilm, moss, detritus, feces, plants, and soil (13,29,39,63,93,106,107,112,113,(144)(145)(146)(147)210). The hypothesis most advanced to aggregate data issuing from the investigations on the environment is that M. ulcerans may be part of a food chain (211,212).…”

Section: Buruli Ulcer In Animalsmentioning

confidence: 99%

Buruli Ulcer, a Prototype for Ecosystem-Related Infection, Caused by Mycobacterium ulcerans

et al. 2018

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Buruli ulcer is a noncontagious disabling cutaneous and subcutaneous mycobacteriosis reported by 33 countries in Africa, Asia, Oceania, and South America. The causative agent, , derives from by genomic reduction and acquisition of a plasmid-borne, nonribosomal cytotoxin mycolactone, the major virulence factor. -specific sequences have been readily detected in aquatic environments in food chains involving small mammals. Skin contamination combined with any type of puncture, including insect bites, is the most plausible route of transmission, and skin temperature of<30°C significantly correlates with the topography of lesions. After 30 years of emergence and increasing prevalence between 1970 and 2010, mainly in Africa, factors related to ongoing decreasing prevalence in the same countries remain unexplained. Rapid diagnosis, including laboratory confirmation at the point of care, is mandatory in order to reduce delays in effective treatment. Parenteral and potentially toxic streptomycin-rifampin is to be replaced by oral clarithromycin or fluoroquinolone combined with rifampin. In the absence of proven effective primary prevention, avoiding skin contamination by means of clothing can be implemented in areas of endemicity. Buruli ulcer is a prototype of ecosystem pathology, illustrating the impact of human activities on the environment as a source for emerging tropical infectious diseases.

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“…A study on a larger number of environmental samples was conducted to study the links between the drivers of freshwater foodwebs in French Guiana and the emergence of M. ulcerans in the environment. A collection of 3600 invertebrates and fish were sampled and catalogued from 17 freshwater sites across French Guiana [7,13]. Landscape data as a measure of land use along a gradient from urban through agricultural to pristine rain forest were extracted from two maps including the CORINE 2006 European land cover map using satellite-derived data and the Hansen deforestation map.…”

Section: Biodiversity Drivers Of M Ulcerans Distribution Across Fresmentioning

confidence: 99%

Mycobacterium ulcerans Infection in French Guiana; Current State of Knowledge

Couppié¹,

Blaizot²,

Velvin

et al. 2019

Buruli Ulcer

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Deforestation-driven food-web collapse linked to emerging tropical infectious disease, Mycobacterium ulcerans

Abstract: Identification of a potential mechanism linking land-use change and the emergence of an infectious disease

Cited by 54 publications

References 42 publications

Pathogen spillover during land conversion

Pathogen spillover during land conversion

Buruli Ulcer, a Prototype for Ecosystem-Related Infection, Caused by Mycobacterium ulcerans

Mycobacterium ulcerans Infection in French Guiana; Current State of Knowledge

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