Definitive Radiotherapy With or Without Chemotherapy for T3-4N0 Squamous Cell Carcinoma of the Maxillary Sinus and Nasal Cavity

Jang, Na Young; Wu, Hong‐Gyun; Park, Charn Il; Heo, Dae Seog; Kim, Dong-Wan; Lee, Se‐Hoon; Rhee, Chae‐Seo

doi:10.1093/jjco/hyq009

Cited by 27 publications

(43 citation statements)

References 18 publications

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“…These reports appear to support our hypothesis. Further, Jang et al reported that the incidence of late neck recurrence was 3.3% in patients with T3-4 N0 maxillary sinus cancer, who underwent definitive radiotherapy without ENI [10]. As 66% of all participants received induction chemotherapy and 10% of them received concurrent chemotherapy in this report, it might be that systemic drug application has the capacity to eliminate occult micrometastases in regional lymphatics to a degree, comparable to that of ENI or surgery.…”

Section: Discussionmentioning

confidence: 57%

The incidence of late neck recurrence in N0 maxillary sinus squamous cell carcinomas after superselective intra-arterial chemoradiotherapy without prophylactic neck irradiation

Sakashita

Homma

Hatakeyama

et al. 2013

Eur Arch Otorhinolaryngol

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The efficacy of elective neck irradiation (ENI) for patients with N0 carcinoma of the maxillary sinus has been controversial. The purpose of our study was to investigate the incidence of late neck recurrence and the mortality rate from regional disease in patients with N0 maxillary sinus cancer after superselective cisplatin infusion and concomitant radiotherapy (RADPLAT) without ENI. We retrospectively analyzed 48 patients with N0 maxillary sinus cancer who underwent RADPLAT. Chemotherapy consisted of 100-120 mg/m 2 superselective intra-arterial cisplatin administered at a median rate of four times weekly. Concurrent radiation therapy was administered at a median dose of 65Gy without ENI. Late neck recurrence was observed in 8.3% (4/48).Three patients underwent salvage neck dissection and survived without any evidence of disease. The remaining patient did not undergo neck dissection due to coexistence with distant metastasis, and he died of regional disease. The mortality rate from regional disease was calculated to be 2% (1/48). The incidence of late neck recurrence was not frequent, and the mortality rate from regional disease was low. Salvage neck dissection was considered to be feasible for patients with late neck recurrence. When definitive radiotherapy and concomitant chemotherapy are applied, it is considered that ENI in not required for cases of N0 maxillary sinus cancer.

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Section: Discussionmentioning

confidence: 57%

The incidence of late neck recurrence in N0 maxillary sinus squamous cell carcinomas after superselective intra-arterial chemoradiotherapy without prophylactic neck irradiation

Sakashita

Homma

Hatakeyama

et al. 2013

Eur Arch Otorhinolaryngol

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“…Yet, in spite of advancements in technology, there has been no significant improvement in the 5-year OS rate since the 1960s. However, retrospective studies have shown reduced radiation-induced toxicity with the use of IMRT in the adjuvant setting and LC rates equal to or better than 3D-CRT [7,[9][10][11][12][13][14][15][16][17][18][19][20][21][22]. In this study, we present the results of 11 patients with SNC treated with definitive RT or CRT, using a two-phase IMRT technique.…”

Section: Discussionmentioning

confidence: 99%

“…Retrospective studies have shown surgery followed by postoperative RT has Electronic supplementary material The online version of this article (doi:10.1007/s13566-015-0226-3) contains supplementary material, which is available to authorized users. superior 5-year local control (LC) rates, ranging from 40 to 79 % [2,[5][6][7] compared with definitive RT or CRT ranging from 20 to 64 % [2,5,[8][9][10][11][12][13][14][15][16][17][18]. However, due to the proximity of SNCs to critical structures such as the brain, optic nerves, orbital contents, and carotid artery, surgery for very locally advanced SNC is often a difficult, if not unattainable, option [3].…”

Section: Introductionmentioning

confidence: 99%

Function preservation and optimal outcomes—definitive chemoradiotherapy with multi-phase treatment planning for locally advanced sinonasal cancer

Burt¹,

Orlandi

Hunt

et al. 2015

J Radiat Oncol

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Objectives The aim of this study is to review radiotherapy (RT) techniques and outcomes for definitive RT or chemoradiotherapy (CRT) for very locally advanced or unresectable sinonasal cancer (SNC) at a single institution. Methods Between 1998 and 2010, there were 11 patients with very locally advanced or unresectable SNCs treated with definitive CRT (8) and RT alone (3) at the University of Utah. CRT was given to stage IVA (5) and stage IVB (3) patients; RT alone was given to stage III (1) and stage IVA (2) patients. All patients were treated with intensity-modulated radiation therapy (IMRT). The median dose was 70.2 Gy (70-72.4 Gy). Most patients underwent two treatment planning phases in order to prevent critical structures from receiving a high dose due to tumor regression and weight loss. The most common chemotherapy was cisplatin 40 mg/m 2 given on a weekly basis for 6-7 cycles. A flexible nasal endoscopy with a biopsy was performed 3 months posttreatment to evaluate tumor response.Results With a median follow-up of 41 months (2-114), overall local control was seen in 8 out of 11 (72.7 %) patients. There was 1 (9.1 %) regional recurrence and 2 (18.2 %) distant metastasis. The definitive CRT or RT was well tolerated with only 2 patients experiencing a grade 3 late toxicity. Conclusion Definitive CRT or RT is feasible for very locally advanced or unresectable SNC. Local control is encouraging with acceptable treatment-related complications when treating with the described two-phase IMRT treatment technique.

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“…Local control rates ranging from 14% to 53% have been reported. [24][25][26][27][28][29] However, many studies are marked by selection bias, and patients treated nonsurgically more often have locally advanced disease or are considered inoperable (Table 7). 23,28,[30][31][32][33] The use of induction chemotherapy for sinonasal squamous cell carcinomas has not been associated with improved local control or a survival advantage.…”

Section: Nonsurgical Management Of Sinonasal Malignanciesmentioning

confidence: 99%

Surgery in the Multimodality Treatment of Sinonasal Malignancies

Lango

Topham

Perlis

et al. 2010

Current Problems in Cancer

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Definitive Radiotherapy With or Without Chemotherapy for T3-4N0 Squamous Cell Carcinoma of the Maxillary Sinus and Nasal Cavity

Abstract: The treatment outcome was poor and local control was a major problem. High radiation dose, effective chemotherapy and elective neck irradiation for advanced nasal cavity cancers may improve disease control.

Cited by 27 publications

References 18 publications

The incidence of late neck recurrence in N0 maxillary sinus squamous cell carcinomas after superselective intra-arterial chemoradiotherapy without prophylactic neck irradiation

The incidence of late neck recurrence in N0 maxillary sinus squamous cell carcinomas after superselective intra-arterial chemoradiotherapy without prophylactic neck irradiation

Function preservation and optimal outcomes—definitive chemoradiotherapy with multi-phase treatment planning for locally advanced sinonasal cancer

Surgery in the Multimodality Treatment of Sinonasal Malignancies

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