Definitive proton radiation therapy and concurrent cisplatin for unresectable head and neck adenoid cystic carcinoma: A series of 9 cases and a critical review of the literature

Bhattasali, O.; Holliday, Emma B.; Kies, Merrill S.; Hanna, Ehab Y.; Garden, Adam S.; Rosenthal, David I.; Morrison, William H.; Gunn, G. Brandon; Fuller, Clifton D.; Zhu, Xiangxin; Frank, Steven J.

doi:10.1002/hed.24262

Cited by 37 publications

(25 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ACC of the trachea, nasopharynx, or maxillary sinus that are unable to undergo surgery have been treated with radiotherapy [18]. The effect of definitive RT for unresectable cases has been reported from several retrospective studies, with a response rate of approximately 40% and RFS of approximately 30 months [19][20][21]. However, it is difficult to obtain long-term remission in unresectable cases by RT alone [22].…”

Section: Discussionmentioning

confidence: 99%

Role of concurrent chemoradiation on locally advanced unresectable adenoid cystic carcinoma

Keam

Ock

et al. 2021

Korean J Intern Med

View full text Add to dashboard Cite

Background/Aims: Adenoid cystic carcinoma (ACC) is a rare salivary gland tumor characterized by indolence, with a high rate of local recurrence and distant metastasis. This study aimed to investigate the effect of concurrent chemoradiation (CCRT) on locally advanced unresectable ACC. Methods: We retrospectively analyzed clinical data from 10 patients with pathologically confirmed ACC of the head and neck who received CCRT with cisplatin in Seoul National University Hospital between 2013 and 2018. Results: Ten patients with unresectable disease at the time of diagnosis or with positive margins after surgical resection received CCRT with weekly cisplatin. Eight patients (80%) achieved complete remission, of which three later developed distant metastases without local relapse; one patient developed distant metastasis and local relapse. Two patient achieved partial remission without progression. Patients experienced several toxicities, including dry mouth, radiation dermatitis, nausea, and salivary gland inflammation of mostly grade 1 to 2. Only one patient showed grade 3 oral mucositis. Median relapse-free survival was 34.5 months (95% confidence interval, 22.8 months to not reached). Conclusions: CCRT with cisplatin is effective for local control of ACC with manageable toxicity and may be an effective treatment option for locally advanced unresectable ACC.

show abstract

Section: Discussionmentioning

confidence: 99%

Role of concurrent chemoradiation on locally advanced unresectable adenoid cystic carcinoma

Keam

Ock

et al. 2021

Korean J Intern Med

View full text Add to dashboard Cite

show abstract

“…3 In our patient sample, 8 patients had definitive radiation with curative intent and 14 patients had definitive chemoradiotherapy with curative intent. 36 Given this recent data and shift in the traditional paradigm, it is important to recognize that chemoradiotherapy with proton beam may be used with curative intent in select patients with nonresectable tumors. 8, 36 Pommier et al 8 treated 23 patients with skull base ACC with combined proton and photon radiotherapy with primary outcomes related to survival.…”

Section: Discussionmentioning

confidence: 99%

“…More recent data, including those from our institution, shows that chemoradiotherapy utilizing proton radiotherapy can be used in the definitive setting. 8,36 Pommier et al 8 treated 23 patients with skull base ACC with combined proton and photon radiotherapy with primary outcomes related to survival. The patients had 93% 5-year LRFS, and 56% and 77% DFS and OS, respectively, survival data that are comparable to that of patients treated surgically.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prognostic factors and survival in adenoid cystic carcinoma of the sinonasal cavity

et al. 2018

Self Cite

View full text Add to dashboard Cite

Background Optimal treatment and prognostic factors affecting long‐term survival in patients with sinonasal adenoid cystic carcinoma (ACC) have yet to be clearly defined. Methods We conducted a retrospective review of patients treated with curative intent from 1980‐2015 at MD Anderson Cancer Center. Results One hundred sixty patients met inclusion criteria, including 8 who were treated with radiotherapy alone. Median follow‐up time was 55 months. The 5‐year overall survival (OS) and disease‐free survival (DFS) rates were 67.0% and 49.0%, respectively. The 10‐year OS and DFS rates were 44.8% and 25.4%, respectively. Factors that portended for poor survival on multivariate analysis were recurrent disease, any solid type histology, epicenter in the sinus cavity, the presence of facial symptoms, or the original disease not treated with surgery. There was no association between surgical margin status or nodal status and survival. Conclusion In this large cohort of patients with sinonasal ACC with extended follow‐up, long‐term survival is better than reported in prior literature. Future research should target patients with adverse risk factors.

show abstract

“…In particular, primary tumours located near the skull base may be treated with this kind of radiotherapy. 6,7 However, current therapeutic options are limited. Thus, the investigation of the underlying mechanisms of carcinogenesis and prognostic markers in ACC is needed to identify new treatment options and to select patients who require intensified therapy.…”

Section: Introductionmentioning

confidence: 99%

Expression of inhibitors of apoptosis proteins in salivary gland adenoid cystic carcinoma: XIAP is an independent marker of impaired cause‐specific survival

Schnoell

Kadletz

Jank

et al. 2020

Clinical Otolaryngology

View full text Add to dashboard Cite

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. Abstract Objectives: Inhibitors of apoptosis proteins are crucial to carcinogenesis since their expression results in evasion of apoptosis. Overexpression of inhibitors of apoptosis has repeatedly been associated with resistance to treatment and poor prognosis in various cancers. The role of inhibitors of apoptosis in adenoid cystic carcinoma of the salivary gland is still unclear. The aim of this study was to investigate the expression of inhibitors of apoptosis and their potential prognostic value in adenoid cystic carcinoma. Design, setting and participants: Forty-nine patients, diagnosed with adenoid cystic carcinoma of the salivary gland between 1996 and 2016, were retrospectively included in this study. The expression of cIAP1, cIAP2, XIAP, Birc6, Livin and Survivin was assessed using immunohistochemistry, and their association of survival and prognosis was evaluated during a median follow-up of 6.4 years.Main outcome measure: Cause-specific survival and recurrence-free survival rates.Results: XIAP, cIAP2, Livin and nuclear Survivin showed high expression levels in adenoid cystic carcinoma in most patients. There was no significant association of cIAP1, cIAP2, Livin, Birc6 and Survivin with outcome. However, high XIAP expression was associated with worse cause-specific survival and worse response to radiotherapy and proved to be an independent marker in multivariable analysis. Conclusion:Our data indicate that high expression of XIAP may be used as a prognosticator for poor survival and poor response to radiotherapy in adenoid cystic carcinoma patients. | 365SCHNOELL Et aL.

show abstract

Definitive proton radiation therapy and concurrent cisplatin for unresectable head and neck adenoid cystic carcinoma: A series of 9 cases and a critical review of the literature

Abstract: Our preliminary results suggest proton RT and concurrent chemotherapy is a definitive treatment option for select patients with head and neck ACC. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1472-E1480, 2016.

Cited by 37 publications

References 31 publications

Role of concurrent chemoradiation on locally advanced unresectable adenoid cystic carcinoma

Role of concurrent chemoradiation on locally advanced unresectable adenoid cystic carcinoma

Prognostic factors and survival in adenoid cystic carcinoma of the sinonasal cavity

Expression of inhibitors of apoptosis proteins in salivary gland adenoid cystic carcinoma: XIAP is an independent marker of impaired cause‐specific survival

Contact Info

Product

Resources

About